KEGG   PATHWAY: aml04814
Entry
aml04814                    Pathway                                
Name
Motor proteins - Ailuropoda melanoleuca (giant panda)
Class
Cellular Processes; Cell motility
Pathway map
aml04814  Motor proteins
aml04814

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100467615  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
100481681  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
100465154  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100483525  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
100470593  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
100464013  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
100475288  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
100475205  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
100478628  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100484588  dynein light chain 1, cytoplasmic [KO:K10418]
117798873  dynein light chain 1, cytoplasmic-like [KO:K10418]
100481075  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
100479703  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
100482230  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
117797415  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
100484209  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
100475829  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
100480180  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
100466439  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
100463984  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
100476836  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
100468408  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
100479181  DNAH6; LOW QUALITY PROTEIN: dynein heavy chain 6, axonemal [KO:K10408]
100472538  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
100464388  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100464687  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
100475674  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
100483064  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
100475798  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
100470974  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
105236869  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
100480789  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
100483639  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
100474035  DNAI3; WD repeat-containing protein 63 [KO:K24722]
100479924  DNAI4; WD repeat-containing protein 78 [KO:K24723]
100478496  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100468807  DNAL1; dynein light chain 1, axonemal isoform X2 [KO:K10411]
100474865  DNAL4; dynein light chain 4, axonemal [KO:K10412]
100475411  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
100479564  DCTN2; dynactin subunit 2 isoform X6 [KO:K10424]
100478449  DCTN3; dynactin subunit 3 [KO:K10425]
100469749  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
100477250  DCTN5; dynactin subunit 5 [KO:K10427]
100473534  DCTN6; dynactin subunit 6 isoform X2 [KO:K10428]
117797767  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
117798362  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
100475780  ACTR1A; alpha-centractin [KO:K16575]
100464465  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100468471  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
100470364  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100478976  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100481414  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100477703  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
100472975  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
100477113  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
100467483  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
100480515  tubulin alpha-8 chain [KO:K07374]
100468269  TUBA4B; LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
100470688  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
100463766  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100464995  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100475162  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
100466505  tubulin alpha-4A chain isoform X2 [KO:K07374]
100468734  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
100463763  TUBB4B; tubulin beta-4B chain [KO:K07375]
100484048  TUBB6; tubulin beta-6 chain [KO:K07375]
100470125  tubulin beta-2 chain [KO:K07375]
100468119  tubulin beta-3 chain [KO:K07375]
100478851  tubulin beta chain-like [KO:K07375]
105240041  tubulin beta chain [KO:K07375]
100475096  TUBB4A; tubulin beta-4A chain [KO:K07375]
100476093  TUBB; tubulin beta chain [KO:K07375]
117800503  tubulin beta-4B chain-like isoform X1 [KO:K07375]
100472117  TUBG1; tubulin gamma-1 chain [KO:K10389]
100472368  tubulin gamma-2 chain isoform X2 [KO:K10389]
100463586  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
100471508  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
100479975  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100474200  KIF5B; kinesin-1 heavy chain [KO:K10396]
100484204  KIF5C; kinesin heavy chain [KO:K10396]
100484737  KLC4; kinesin light chain 4 [KO:K10407]
100481191  KLC3; kinesin light chain 3 [KO:K10407]
100464655  KLC1; kinesin light chain 1 isoform X3 [KO:K10407]
100483172  KLC2; kinesin light chain 2 [KO:K10407]
100482724  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
100474961  KIF3B; kinesin-like protein KIF3B [KO:K20196]
100466907  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
100470660  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
100464861  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
100478514  KIF1B; kinesin-like protein KIF1B isoform X6 [KO:K10392]
100478087  KIF1A; kinesin-like protein KIF1A isoform X1 [KO:K10392]
100466618  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
100469083  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
100478946  KIF13A; kinesin-like protein KIF13A [KO:K17914]
105235521  KIF14; kinesin-like protein KIF14 [KO:K17915]
100483437  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
100469478  STARD9; stAR-related lipid transfer protein 9 isoform X9 [KO:K16491]
100477054  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
100476891  KIF7; kinesin-like protein KIF7 [KO:K18806]
100473088  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
100467876  KIF21A; kinesin-like protein KIF21A isoform X2 [KO:K24185]
100475863  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
100481738  KIF11; kinesin-like protein KIF11 [KO:K10398]
100482186  KIF20A; kinesin-like protein KIF20A isoform X1 [KO:K10402]
100483998  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
100480244  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
105235229  CENPE; LOW QUALITY PROTEIN: centromere-associated protein E [KO:K11498]
100467416  KIF18A; kinesin-like protein KIF18A [KO:K10401]
100464993  KIF18B; kinesin-like protein KIF18B isoform X2 [KO:K26156]
100483893  KIF19; kinesin-like protein KIF19 [KO:K26157]
100479454  kinesin-like protein KIF19 [KO:K26157]
100466790  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
105241446  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
100474412  KIF22; kinesin-like protein KIF22 [KO:K10403]
100480921  KIF26A; kinesin-like protein KIF26A isoform X1 [KO:K10404]
100479156  KIF26B; kinesin-like protein KIF26B [KO:K10404]
100478052  kinesin-like protein KIF12 isoform X6 [KO:K10399]
100484064  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
100474833  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
100468186  KIF2B; kinesin-like protein KIF2B [KO:K10393]
100466369  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
100471340  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
100473250  KIFC1; kinesin-like protein KIFC1 isoform X2 [KO:K10405]
100472728  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
100477576  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
100483345  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
100475948  MYO1A; unconventional myosin-Ia isoform X5 [KO:K10356]
100484346  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
100477652  MYO1H; unconventional myosin-Ih [KO:K10356]
100471849  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
100463962  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
100477681  MYO1F; unconventional myosin-If [KO:K10356]
100479750  MYO1G; unconventional myosin-Ig isoform X1 [KO:K10356]
100476756  MYO1E; unconventional myosin-Ie [KO:K10356]
100474371  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
100467620  MYO3A; myosin-IIIa isoform X1 [KO:K08834] [EC:2.7.11.1]
100467505  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
100467758  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
100476593  MYO5B; unconventional myosin-Vb [KO:K10357]
100467348  MYO6; unconventional myosin-VI isoform X3 [KO:K10358]
100478193  MYO7A; LOW QUALITY PROTEIN: unconventional myosin-VIIa [KO:K10359]
100476673  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
100475644  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
100473414  MYO9B; unconventional myosin-IXb isoform X6 [KO:K10360]
100477236  MYO10; unconventional myosin-X [KO:K12559]
100475815  MYO15A; unconventional myosin-XV [KO:K10361]
100479588  MYO15B; myosin XVB [KO:K10361]
105236092  MYO16; LOW QUALITY PROTEIN: unconventional myosin-XVI [KO:K17481]
100478634  MYO18A; unconventional myosin-XVIIIa isoform X13 [KO:K10362]
100474400  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
100482937  LOW QUALITY PROTEIN: myosin-1-like [KO:K24220]
100483607  LOW QUALITY PROTEIN: myosin-8 [KO:K24220]
100482687  LOW QUALITY PROTEIN: myosin-2-like [KO:K24220]
100482254  myosin-3 [KO:K24220]
100469409  MYH7B; myosin-7B [KO:K24220]
100480272  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
100483191  LOW QUALITY PROTEIN: myosin-4 [KO:K24220]
100463666  MYH13; LOW QUALITY PROTEIN: myosin-13 [KO:K24220]
100469933  LOW QUALITY PROTEIN: myosin-7 [KO:K17751]
100470185  MYH6; LOW QUALITY PROTEIN: myosin-6 [KO:K17751]
100466547  MYH9; myosin-9 [KO:K10352]
100468242  MYH14; myosin-14 [KO:K10352]
100473449  MYH10; myosin-10 isoform X2 [KO:K10352]
100484803  MYH11; myosin-11 isoform X1 [KO:K10352]
100466173  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
117800069  myosin light chain 3, skeletal muscle isoform-like [KO:K05738]
100466054  MYL3; myosin light chain 3 [KO:K12749]
117799519  myosin light chain 1, cardiac muscle [KO:K12749]
100475266  MYL4; myosin light chain 4 isoform X4 [KO:K12750]
100469999  MYL6B; myosin light chain 6B [KO:K12751]
100470421  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
117798907  myosin light polypeptide 6 [KO:K12751]
100483724  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100480867  MYL5; myosin light chain 5 [KO:K12753]
100475493  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100465571  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100480951  MYL10; myosin regulatory light chain 10 [KO:K12756]
100471142  myosin regulatory light chain 12B [KO:K12757]
100472299  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
117799888  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
100480191  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117799351  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
100473191  ACTA1; actin, alpha skeletal muscle [KO:K10354]
117800084  actin, alpha skeletal muscle-like [KO:K10354]
100470496  ACTA2; actin, aortic smooth muscle [KO:K12313]
100464234  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
100476728  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
100466132  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100481739  actin [KO:K05692]
117800125  actin, cytoplasmic 1 [KO:K05692]
117800181  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
117800361  actin, cytoplasmic 1-like [KO:K05692]
117800408  actin, cytoplasmic 1 [KO:K05692]
100484935  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
117800158  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
100472082  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
100471217  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
100473401  TNNC2; troponin C, skeletal muscle [KO:K12042]
117800170  troponin C, skeletal muscle [KO:K12042]
100482680  TNNI2; troponin I, fast skeletal muscle isoform X2 [KO:K12043]
117799870  troponin I, fast skeletal muscle-like [KO:K12043]
100482930  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
117800071  troponin T, fast skeletal muscle-like [KO:K12046]
100471638  TNNI3; troponin I, cardiac muscle [KO:K12044]
100467396  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
100465955  TPM1; tropomyosin alpha-1 chain isoform X15 [KO:K10373]
117799593  tropomyosin alpha-1 chain-like [KO:K10373]
100471103  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
100482767  TPM3; tropomyosin alpha-3 chain isoform X7 [KO:K09290]
117799607  tropomyosin alpha-3 chain-like [KO:K09290]
100470823  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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