KEGG   PATHWAY: asn04141
Entry
asn04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Alligator sinensis (Chinese alligator)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
asn04141  Protein processing in endoplasmic reticulum
asn04141

Other DBs
GO: 0030433 0034976
Organism
Alligator sinensis (Chinese alligator) [GN:asn]
Gene
102373630  SEC61A2; LOW QUALITY PROTEIN: protein transport protein Sec61 subunit alpha [KO:K10956]
102381045  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
102385013  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
102376864  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
102372369  SEC62; translocation protein SEC62 [KO:K12275]
102374581  SEC63; translocation protein SEC63 homolog [KO:K09540]
102369358  RPN1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
102370758  RPN2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2 [KO:K12667]
102378691  DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
102383937  STT3A; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
102381490  STT3B; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
102380185  MAGT1; magnesium transporter protein 1 isoform X1 [KO:K19478]
102380884  TUSC3; tumor suppressor candidate 3 [KO:K19478]
102369671  OSTC; oligosaccharyltransferase complex subunit OSTC [KO:K26501]
102378782  TMEM258; transmembrane protein 258 [KO:K26502]
112548011  MOGS; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
102369382  CKAP4; cytoskeleton-associated protein 4 [KO:K13999]
102375631  RRBP1; ribosome-binding protein 1 isoform X1 [KO:K14000]
102374365  SIL1; nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
102367994  HYOU1; hypoxia up-regulated protein 1 [KO:K09486]
102382114  HSPA5; LOW QUALITY PROTEIN: endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102373808  DNAJB11; dnaJ homolog subfamily B member 11 [KO:K09517]
102373881  DNAJC1; dnaJ homolog subfamily C member 1 [KO:K09521]
102380397  DNAJC3; dnaJ homolog subfamily C member 3 [KO:K09523]
102379400  dnaJ homolog subfamily C member 3-like [KO:K09523]
102382560  DNAJC10; LOW QUALITY PROTEIN: dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
102367863  HSP90B1; endoplasmin [KO:K09487]
102375566  GANAB; neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
102379677  PRKCSH; LOW QUALITY PROTEIN: glucosidase 2 subunit beta [KO:K08288]
102374159  CANX; LOW QUALITY PROTEIN: calnexin [KO:K08054]
102387284  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102380818  CALR; calreticulin [KO:K08057]
102380341  CALR3; calreticulin-3 [KO:K08057]
102369572  MAN1A1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
102378356  MAN1C1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1 [KO:K01230] [EC:3.2.1.113]
102388362  MAN1A2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB isoform X1 [KO:K01230] [EC:3.2.1.113]
102387590  MAN1B1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1 [KO:K23741] [EC:3.2.1.209]
102381215  LMAN1; protein ERGIC-53 [KO:K10080]
102369851  PREB; prolactin regulatory element-binding protein [KO:K14003]
102381040  SAR1B; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
102367783  SAR1A; GTP-binding protein SAR1a [KO:K07953] [EC:3.6.5.-]
102378054  SEC13; protein SEC13 homolog [KO:K14004]
102382840  SEC31B; protein transport protein Sec31B [KO:K14005]
102383413  SEC31A; protein transport protein Sec31A isoform X1 [KO:K14005]
102379055  SEC23B; protein transport protein Sec23B [KO:K14006]
102379389  SEC23A; protein transport protein Sec23A [KO:K14006]
102375023  SEC24C; protein transport protein Sec24C isoform X1 [KO:K14007]
102383278  SEC24D; protein transport protein Sec24D [KO:K14007]
102380792  SEC24A; protein transport protein Sec24A isoform X1 [KO:K14007]
102370176  SEC24B; protein transport protein Sec24B [KO:K14007]
102374780  UGGT1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X2 [KO:K11718] [EC:2.4.1.-]
102380628  UGGT2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
102381482  EDEM1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
102378524  LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
102383381  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
102374269  EDEM3; ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
102384480  P4HB; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
102373241  PDIA4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
102368028  PDIA6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
102372262  ERP29; endoplasmic reticulum resident protein 29 [KO:K09586]
102375300  TXNDC5; thioredoxin domain-containing protein 5 isoform X1 [KO:K13984] [EC:5.3.4.1]
102384857  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
102379246  ERO1B; ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
102367825  OS9; protein OS-9 [KO:K10088]
102385349  ERLEC1; endoplasmic reticulum lectin 1 [KO:K14008]
102388448  SSR1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
102382339  SSR2; translocon-associated protein subunit beta isoform X1 [KO:K13250]
102387648  SSR3; translocon-associated protein subunit gamma [KO:K13251]
102385057  SSR4; translocon-associated protein subunit delta isoform X1 [KO:K04571]
102368379  BCAP31; B-cell receptor-associated protein 31 isoform X2 [KO:K14009]
102368742  TRAM1; translocating chain-associated membrane protein 1 [KO:K14010]
102387990  translocating chain-associated membrane protein 1-like isoform X1 [KO:K14010]
102382742  DERL1; derlin-1 [KO:K11519]
102385096  derlin-2 isoform X1 [KO:K13989]
102370805  DERL2; derlin-2 isoform X1 [KO:K13989]
102369886  UBXN4; UBX domain-containing protein 4 [KO:K24348]
102376054  UBXN1; UBX domain-containing protein 1 [KO:K24348]
102386099  UBXN2A; UBX domain-containing protein 2A isoform X1 [KO:K24349]
102371792  UBXN6; UBX domain-containing protein 6 isoform X2 [KO:K14011]
102384540  NSFL1C; NSFL1 cofactor p47 [KO:K14012]
112549787  SVIP; small VCP/p97-interacting protein [KO:K14014]
102369218  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
102369078  NPLOC4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
102377408  UFD1; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
102387087  HSPA8; heat shock cognate 71 kDa protein isoform X2 [KO:K03283]
102368981  heat shock 70 kDa protein II-like [KO:K03283]
102368266  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A-like [KO:K03283]
102386331  DNAJA1; dnaJ homolog subfamily A member 1 [KO:K09502]
102369165  dnaJ homolog subfamily A member 1-like [KO:K09502]
102372588  DNAJA2; dnaJ homolog subfamily A member 2 [KO:K09503]
102370438  DNAJB1; dnaJ homolog subfamily B member 1 [KO:K09507]
102370744  DNAJB2; dnaJ homolog subfamily B member 2 [KO:K09508]
102388026  DNAJB12; LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 12 [KO:K09518]
102382358  DNAJC5B; dnaJ homolog subfamily C member 5B [KO:K09525]
102370120  dnaJ homolog subfamily C member 5-like [KO:K09525]
102378938  DNAJC5; dnaJ homolog subfamily C member 5 [KO:K09525]
102369112  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102379894  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102387736  HSPA4L; LOW QUALITY PROTEIN: heat shock 70 kDa protein 4L [KO:K09485]
102372496  HSPH1; heat shock protein 105 kDa isoform X1 [KO:K09485]
102369283  BAG1; BAG family molecular chaperone regulator 1 [KO:K09555]
102384591  BAG2; LOW QUALITY PROTEIN: BAG family molecular chaperone regulator 2 [KO:K09556]
102387982  HSPBP1; hsp70-binding protein 1 [KO:K09562]
102380355  CRYAA; alpha-crystallin A chain [KO:K09541]
102388352  CRYAB; alpha-crystallin B chain [KO:K09542]
102371309  YOD1; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
102375217  PLAA; phospholipase A-2-activating protein isoform X1 [KO:K14018]
102381061  RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
102370682  RAD23B; UV excision repair protein RAD23 homolog B isoform X2 [KO:K10839]
102370422  UBQLN4; ubiquilin-4 [KO:K04523]
102372140  UBQLN1; ubiquilin-1 [KO:K04523]
102371352  ubiquilin-1-like [KO:K04523]
102383348  NGLY1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
102376144  ATXN3; ataxin-3 isoform X3 [KO:K11863] [EC:3.4.22.-]
102369697  UBE4B; ubiquitin conjugation factor E4 B isoform X2 [KO:K10597] [EC:2.3.2.27]
102374223  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102387558  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
102369745  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
102376825  PPP1R15A; protein phosphatase 1 regulatory subunit 15A [KO:K14019]
102384643  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102370035  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102381020  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
102383000  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
102378020  WFS1; wolframin [KO:K14020]
102387504  MBTPS1; membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
102387796  MBTPS2; membrane-bound transcription factor site-2 protease isoform X1 [KO:K07765] [EC:3.4.24.85]
102380131  XBP1; X-box-binding protein 1 [KO:K09027]
102388413  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102370398  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102384689  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102375722  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102372350  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102376154  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102374542  mitogen-activated protein kinase 10 isoform X6 [KO:K04440] [EC:2.7.11.24]
102376040  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
102384471  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102374149  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
102368421  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
102375021  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
102373508  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102371021  MARCH6; E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
102377414  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
102388583  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
102372317  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
102379957  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
102375832  SYVN1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
102373463  RNF185; E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
102376022  SELENOS; selenoprotein S [KO:K14025]
102379404  SEL1L; protein sel-1 homolog 1 [KO:K14026]
102380916  SEL1L2; protein sel-1 homolog 2 [KO:K14026]
102380839  HERPUD1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
102386411  AMFR; E3 ubiquitin-protein ligase AMFR isoform X2 [KO:K10636] [EC:2.3.2.36]
102377383  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
102371505  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
102388396  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
102377370  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
102381887  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102372162  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
102371987  CUL1; cullin-1 isoform X2 [KO:K03347]
102382934  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102372433  F-box only protein 2 isoform X1 [KO:K10099]
102388487  F-box only protein 6 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
asn00510  N-Glycan biosynthesis
asn03050  Proteasome
asn03060  Protein export
asn04210  Apoptosis
KO pathway
ko04141   
LinkDB

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