KEGG   PATHWAY: caua04370
Entry
caua04370                   Pathway                                
Name
VEGF signaling pathway - Carassius auratus (goldfish)
Description
There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class
Environmental Information Processing; Signal transduction
Pathway map
caua04370  VEGF signaling pathway
caua04370

Other DBs
GO: 0048010
Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113048546  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
113116535  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
113058303  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
113064204  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
113064357  snake venom vascular endothelial growth factor toxin ICPP-like [KO:K05448]
113064358  snake venom vascular endothelial growth factor toxin ICPP-like [KO:K05448]
113059793  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
113120988  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113063322  vascular endothelial growth factor receptor 2-like [KO:K05098] [EC:2.7.10.1]
113120125  uncharacterized protein LOC113120125 isoform X1 [KO:K08273]
113062364  uncharacterized protein LOC113062364 [KO:K08273]
113040970  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
113068656  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
113061559  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
113061561  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
113118238  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
113049910  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113097507  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
113047101  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113053289  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113047295  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113093357  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113079629  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
113044532  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113070457  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113044866  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
113116357  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
113059935  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
113055031  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113067871  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113067876  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113055812  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113079872  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
113116044  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
113106249  GTPase HRas [KO:K02833]
113067303  GTPase HRas-like [KO:K02833]
113043599  GTPase HRas-like [KO:K02833]
113051345  GTPase HRas-like [KO:K02833]
113067076  ras-like protein isoform X1 [KO:K07827]
113043474  GTPase HRas-like [KO:K07827]
113043560  GTPase KRas [KO:K07827]
113046915  GTPase HRas-like [KO:K07827]
113106980  GTPase NRas-like [KO:K07828]
113071752  GTPase NRas [KO:K07828]
113083541  GTPase NRas-like [KO:K07828]
113054940  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113068641  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
113061451  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
113118360  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113045154  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113045216  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113064928  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
113039644  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113047409  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113068089  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113072016  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113046952  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
113094578  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113062352  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113062962  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113069794  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113115927  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113070145  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070146  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070147  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070154  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070174  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070191  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070198  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
113070215  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113070798  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113045808  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
113117207  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113086959  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113086991  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087107  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087123  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113087139  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113087155  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
113117853  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
113054264  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113076543  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113113737  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113049916  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113069972  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113109787  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113057688  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113038475  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113064066  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
113113102  calcineurin subunit B type 1-like [KO:K06268]
113048743  calcineurin subunit B type 1-like [KO:K06268]
113043992  calcineurin subunit B type 1 [KO:K06268]
113044093  calcineurin subunit B type 1 [KO:K06268]
113057414  calcineurin subunit B type 1-like [KO:K06268]
113041273  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113050155  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113104667  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
113065408  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113065879  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
113120750  prostaglandin G/H synthase 2-like isoform X1 [KO:K11987] [EC:1.14.99.1]
113062963  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113115972  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113045805  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113072624  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
113119735  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113119742  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113079404  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113062549  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113116086  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113059175  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
113070302  SHC-transforming protein 2-like isoform X1 [KO:K17447]
113039600  SHC-transforming protein 2-like isoform X1 [KO:K17447]
113106948  caskin-1-like isoform X1 [KO:K05760]
113068000  paxillin-like isoform X1 [KO:K05760]
113052734  uncharacterized protein LOC113052734 isoform X1 [KO:K05760]
113052801  actin cytoskeleton-regulatory complex protein PAN1-like isoform X1 [KO:K05760]
113073163  proteoglycan 4-like isoform X1 [KO:K05760]
113041157  cell division control protein 42 homolog isoform X1 [KO:K04393]
113055466  cell division control protein 42 homolog isoform X1 [KO:K04393]
113055513  cell division control protein 42 homolog isoform X1 [KO:K04393]
113116067  cell division control protein 42 homolog [KO:K04393]
113081684  cell division control protein 42 homolog [KO:K04393]
113099586  cell division control protein 42 homolog [KO:K04393]
113110861  cell division control protein 42 homolog isoform X1 [KO:K04393]
113041113  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
113047963  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113047964  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113092486  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
113106988  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113048526  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113048528  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113076476  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
113093289  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
113055097  mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113107629  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113069393  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
113058295  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
113064191  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113100762  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
113074136  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
113118260  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
113055239  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
113107370  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
113111235  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
113055334  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
113110933  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
113075367  heat shock protein beta-1-like [KO:K04455]
113049353  alpha-crystallin A chain-like [KO:K04455]
113068050  heat shock protein beta-1-like [KO:K04455]
113073440  heat shock protein beta-1-like [KO:K04455]
113041276  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113065632  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113041468  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
113041653  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
113055327  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
113115353  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113110936  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113065541  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
113065620  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
113049849  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
113050519  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
113116354  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
113083631  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113100537  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113045905  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
113046111  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
113039997  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
113047578  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113056320  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113050659  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113111917  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113053272  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113042869  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113047007  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113042680  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
113056438  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
113098972  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113102919  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113112072  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K07861]
113112806  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113076709  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113061850  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113121267  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113057112  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113110086  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
113110125  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
113117798  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113117811  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113059652  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113118592  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113068938  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
113065546  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
113079035  bcl2-associated agonist of cell death-like [KO:K02158]
113038511  bcl2-associated agonist of cell death-like isoform X1 [KO:K02158]
113064149  bcl2-associated agonist of cell death-like [KO:K02158]
113052085  bcl2-associated agonist of cell death-like [KO:K02158]
113105840  bcl2-associated agonist of cell death-like [KO:K02158]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:13678960
  Authors
Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
  Title
VEGF-receptor signal transduction.
  Journal
Trends Biochem Sci 28:488-94 (2003)
DOI:10.1016/S0968-0004(03)00193-2
Reference
PMID:11741095
  Authors
Matsumoto T, Claesson-Welsh L.
  Title
VEGF receptor signal transduction.
  Journal
Sci STKE 2001:RE21 (2001)
DOI:10.1126/stke.2001.112.re21
Reference
PMID:15602010
  Authors
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
  Title
Vascular endothelial growth factor and angiogenesis.
  Journal
Pharmacol Rev 56:549-80 (2004)
DOI:10.1124/pr.56.4.3
Reference
PMID:16104843
  Authors
Takahashi H, Shibuya M.
  Title
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
  Journal
Clin Sci (Lond) 109:227-41 (2005)
DOI:10.1042/CS20040370
Reference
PMID:14641020
  Authors
Zachary I.
  Title
VEGF signalling: integration and multi-tasking in endothelial cell biology.
  Journal
Biochem Soc Trans 31:1171-7 (2003)
DOI:10.1042/bst0311171
Reference
PMID:15338053
  Authors
Munoz-Chapuli R, Quesada AR, Angel Medina M.
  Title
Angiogenesis and signal transduction in endothelial cells.
  Journal
Cell Mol Life Sci 61:2224-43 (2004)
DOI:10.1007/s00018-004-4070-7
Reference
PMID:14724572
  Authors
Lamalice L, Houle F, Jourdan G, Huot J.
  Title
Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
  Journal
Oncogene 23:434-45 (2004)
DOI:10.1038/sj.onc.1207034
Reference
PMID:12391145
  Authors
Shu X, Wu W, Mosteller RD, Broek D.
  Title
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
  Journal
Mol Cell Biol 22:7758-68 (2002)
DOI:10.1128/MCB.22.22.7758-7768.2002
Related
pathway
caua00590  Arachidonic acid metabolism
caua04010  MAPK signaling pathway
caua04020  Calcium signaling pathway
caua04510  Focal adhesion
KO pathway
ko04370   
LinkDB

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