KEGG   PATHWAY: cbai04727
Entry
cbai04727                   Pathway                                
Name
GABAergic synapse - Camelus bactrianus (Bactrian camel)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
cbai04727  GABAergic synapse
cbai04727

Other DBs
GO: 0051932
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105076157  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
105076160  SLC38A2; sodium-coupled neutral amino acid transporter 2 [KO:K14207]
105075879  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105063981  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
105076792  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
105073990  glutamate decarboxylase 1-like [KO:K01580] [EC:4.1.1.15]
105065117  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
105071951  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
105074595  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
105074918  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
105074920  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
105082620  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
105082621  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
105062095  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
105070071  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
105074917  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
105082619  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105062094  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
105074922  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
105074773  gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
105082624  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
105071050  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
105070087  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
105070061  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
105082640  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105073493  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105079344  HAP1; huntingtin-associated protein 1 [KO:K04647]
105077483  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105078709  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
105062205  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105071485  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
105082298  TRAK2; trafficking kinesin-binding protein 2 isoform X1 [KO:K15374]
105082320  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
105074685  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
105071884  SLC12A5; LOW QUALITY PROTEIN: solute carrier family 12 member 5 [KO:K23967]
105077935  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
105064121  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
105064122  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
105068402  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105073404  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105076642  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105079596  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105079415  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105070011  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105084061  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
105067386  GABBR2; LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105078712  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
105071051  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105067755  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105071086  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105063316  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105080494  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105070137  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105075111  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105069319  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
105062549  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
105082939  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105068344  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
105065706  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105082944  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105080525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105081234  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105063873  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105068818  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105076187  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105074271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105082946  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105064797  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105072485  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
105067460  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
105076672  SLC6A13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
105067576  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
105076344  SLC6A12; LOW QUALITY PROTEIN: sodium- and chloride-dependent betaine transporter [KO:K05045]
105068938  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
105080235  SLC38A3; sodium-coupled neutral amino acid transporter 3 isoform X1 [KO:K13576]
105079383  SLC38A5; sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
cbai00020  Citrate cycle (TCA cycle)
cbai00250  Alanine, aspartate and glutamate metabolism
cbai04144  Endocytosis
cbai04721  Synaptic vesicle cycle
KO pathway
ko04727   
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