KEGG   PATHWAY: cbrc00260
Entry
cbrc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Corvus brachyrhynchos (American crow)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cbrc00260  Glycine, serine and threonine metabolism
cbrc00260

Module
cbrc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cbrc00260]
cbrc_M00047  Creatine pathway [PATH:cbrc00260]
cbrc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cbrc00260]
cbrc_M00555  Betaine biosynthesis, choline => betaine [PATH:cbrc00260]
cbrc_M00621  Glycine cleavage system [PATH:cbrc00260]
cbrc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cbrc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Corvus brachyrhynchos (American crow) [GN:cbrc]
Gene
108445796  LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
103611879  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
103615389  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
103611959  AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
103618990  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
103614275  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
103624539  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
103624705  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
103612724  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
103616466  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
103621527  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
103618219  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
103613274  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
103614378  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
103615014  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
103615015  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
103624470  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
103624478  AOC3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
103614629  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
103614351  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
103623470  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
103620235  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
103615946  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
103612921  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
103621332  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
103622191  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
103614293  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
103611637  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103622046  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
103622044  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
103616258  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
103617483  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
103614914  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
103614844  cystathionine beta-synthase isoform X3 [KO:K01697] [EC:4.2.1.22]
103621866  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
103621814  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
103621160  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
103623745  putative threonine dehydratase isoform X1 [KO:K01754] [EC:4.3.1.19]
103623786  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
103621575  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cbrc00010  Glycolysis / Gluconeogenesis
cbrc00020  Citrate cycle (TCA cycle)
cbrc00230  Purine metabolism
cbrc00250  Alanine, aspartate and glutamate metabolism
cbrc00270  Cysteine and methionine metabolism
cbrc00290  Valine, leucine and isoleucine biosynthesis
cbrc00330  Arginine and proline metabolism
cbrc00470  D-Amino acid metabolism
cbrc00564  Glycerophospholipid metabolism
cbrc00600  Sphingolipid metabolism
cbrc00620  Pyruvate metabolism
cbrc00630  Glyoxylate and dicarboxylate metabolism
cbrc00640  Propanoate metabolism
cbrc00860  Porphyrin metabolism
cbrc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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