KEGG   PATHWAY: cbrc00230
Entry
cbrc00230                   Pathway                                
Name
Purine metabolism - Corvus brachyrhynchos (American crow)
Class
Metabolism; Nucleotide metabolism
Pathway map
cbrc00230  Purine metabolism
cbrc00230

Module
cbrc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cbrc00230]
cbrc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cbrc00230]
cbrc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cbrc00230]
cbrc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cbrc00230]
cbrc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cbrc00230]
cbrc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cbrc00230]
Other DBs
GO: 0006163 0042278
Organism
Corvus brachyrhynchos (American crow) [GN:cbrc]
Gene
103611393  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103611656  [KO:K12324] [EC:4.6.1.2]
103611726  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
103611848  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
103611920  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103612227  AK7; LOW QUALITY PROTEIN: adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
103612249  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
103612478  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103612682  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103612715  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
103612803  [KO:K00365] [EC:1.7.3.3]
103612953  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
103613185  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
103613237  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
103613835  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
103614036  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
103614095  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103614133  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
103614445  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
103614456  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
103614595  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
103614848  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
103614902  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X4 [KO:K12305] [EC:3.6.1.6]
103615142  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
103615276  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103615565  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
103615731  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
103615820  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X5 [KO:K01510] [EC:3.6.1.5]
103616390  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
103616445  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
103616532  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
103616542  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
103616683  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
103616840  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
103616846  AK2; adenylate kinase 2, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
103617089  [KO:K00760] [EC:2.4.2.8]
103617101  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103617147  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
103617248  [KO:K00760] [EC:2.4.2.8]
103617300  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X4 [KO:K19021] [EC:3.1.4.17]
103617326  PAPSS1; LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103617369  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
103617371  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
103617474  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X2 [KO:K01511] [EC:3.6.1.6]
103617642  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
103617850  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
103618104  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
103618132  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
103618163  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
103618680  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X6 [KO:K13755] [EC:3.1.4.17]
103618790  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103618957  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103618984  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
103619317  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103619391  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
103619415  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
103619426  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103619491  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
103619636  [KO:K12319] [EC:4.6.1.2]
103619683  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103619762  [KO:K01510] [EC:3.6.1.5]
103619763  [KO:K01510] [EC:3.6.1.5]
103619809  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
103620194  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
103620279  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
103620317  NT5DC4; 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
103620467  NME3; nucleoside diphosphate kinase 3 isoform X2 [KO:K00940] [EC:2.7.4.6]
103620492  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103620565  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
103620865  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
103621056  [KO:K12322] [EC:4.6.1.2]
103621200  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
103621274  [KO:K18437] [EC:3.1.4.53]
103621467  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
103621468  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
103621548  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
103621602  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
103621724  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
103621738  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
103621821  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103621832  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103621838  RRM1; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103621942  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
103622024  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
103622337  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
103622425  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103622558  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
103622559  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103622623  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
103622774  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
103622824  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
103622861  [KO:K01081] [EC:3.1.3.5]
103623140  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
103623189  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
103623462  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
103623540  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103623705  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
103623766  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
103623837  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
103623920  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
103624117  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
103624159  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
103624341  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103624528  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X4 [KO:K01510] [EC:3.6.1.5]
103624564  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
103624618  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
103624694  CECR1; adenosine deaminase CECR1 isoform X1 [KO:K19572] [EC:3.5.4.4]
103624848  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3 [KO:K18436] [EC:3.1.4.53]
103624937  [KO:K01081] [EC:3.1.3.5]
103625031  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
103625043  [KO:K00940] [EC:2.7.4.6]
103625142  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X2 [KO:K13758]
103625278  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
103625453  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
103625458  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
108449136  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cbrc00030  Pentose phosphate pathway
cbrc00220  Arginine biosynthesis
cbrc00250  Alanine, aspartate and glutamate metabolism
cbrc00260  Glycine, serine and threonine metabolism
cbrc00340  Histidine metabolism
cbrc00630  Glyoxylate and dicarboxylate metabolism
cbrc00730  Thiamine metabolism
cbrc00740  Riboflavin metabolism
cbrc00790  Folate biosynthesis
KO pathway
ko00230   

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