Entry Name Intestinal immune network for IgA production - Cyprinus carpio (common carp)
Description The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ccar04672 Intestinal immune network for IgA production
Ortholog table Other DBs Organism Cyprinus carpio (common carp) [GN:
ccar ]
Gene 109052650 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109053239 LOW QUALITY PROTEIN: H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109053241 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
109053242 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
109052679 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109053193 H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752 ]
109112544 HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752 ]
109109117 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109109118 H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752 ]
109056324 H-2 class II histocompatibility antigen, E-D alpha chain-like [KO:K06752 ]
109051706 H-2 class II histocompatibility antigen, A-U alpha chain-like isoform X1 [KO:K06752 ]
109051707 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109068517 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
109112903 HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752 ]
109060117 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109060118 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109094894 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109084771 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109084772 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
109095323 rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752 ]
109095325 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
109107207 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
109061736 H-2 class II histocompatibility antigen, I-E beta chain-like [KO:K06752 ]
109061739 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
109082076 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109101049 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
109102785 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
109099074 tumor necrosis factor ligand superfamily member 13-like [KO:K05475 ]
109070675 tumor necrosis factor ligand superfamily member 13B-like isoform X1 [KO:K05476 ]
109083941 tumor necrosis factor ligand superfamily member 13B-like isoform X1 [KO:K05476 ]
109085849 tumor necrosis factor receptor superfamily member 13B-like [KO:K05150 ]
109060794 tumor necrosis factor receptor superfamily member 13B-like [KO:K05150 ]
109107798 tumor necrosis factor receptor superfamily member 17-like [KO:K05153 ]
109053146 tumor necrosis factor receptor superfamily member 17-like [KO:K05153 ]
109099063 tumor necrosis factor receptor superfamily member 13C-like isoform X1 [KO:K05151 ]
109051919 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160 ]
109101015 tumor necrosis factor receptor superfamily member 5-like [KO:K03160 ]
109054513 LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4-like [KO:K04189 ]
109104857 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03159 ]
109110036 LOW QUALITY PROTEIN: polymeric immunoglobulin receptor-like [KO:K13073 ]
Compound Reference Authors Fagarasan S, Honjo T
Title Intestinal IgA synthesis: regulation of front-line body defences.
Journal Reference Authors Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
Title The immune geography of IgA induction and function.
Journal Reference Authors Kunisawa J, Kiyono H
Title A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Journal Reference Authors Cerutti A, Rescigno M
Title The biology of intestinal immunoglobulin A responses.
Journal Reference Authors Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
Title Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
Journal Reference Authors Corthesy B
Title Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal Reference Authors Suzuki K, Fagarasan S
Title How host-bacterial interactions lead to IgA synthesis in the gut.
Journal Reference Authors Mora JR, von Andrian UH
Title Differentiation and homing of IgA-secreting cells.
Journal Reference Authors Suzuki K, Ha SA, Tsuji M, Fagarasan S
Title Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Journal Reference Authors Cerutti A
Title The regulation of IgA class switching.
Journal KO pathway LinkDB All DBs
