KEGG   PATHWAY: cclu00270
Entry
cclu00270                   Pathway                                
Name
Cysteine and methionine metabolism - Coregonus clupeaformis (lake whitefish)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
cclu00270  Cysteine and methionine metabolism
cclu00270

Module
cclu_M00034  Methionine salvage pathway [PATH:cclu00270]
cclu_M00035  Methionine degradation [PATH:cclu00270]
cclu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cclu00270]
Other DBs
GO: 0006534 0006555
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121533631  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
121576833  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
121582103  kyat1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121534148  kynurenine--oxoglutarate transaminase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121571610  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
121572304  cbsa; cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
121536508  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
121582649  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
121541555  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
121576420  zgc:172121; homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]
121578450  LOW QUALITY PROTEIN: methionine synthase [KO:K00548] [EC:2.1.1.13]
121582401  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121584879  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
121530947  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
121547250  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
121580144  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
121574146  mat2al; methionine adenosyltransferase II, alpha-like isoform X1 [KO:K00789] [EC:2.5.1.6]
121574735  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
121541770  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121542137  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121553633  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
121548998  S-adenosylmethionine decarboxylase proenzyme-like isoform X1 [KO:K01611] [EC:4.1.1.50]
121552213  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
121538377  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
121579545  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
121541911  spermine synthase isoform X1 [KO:K00802] [EC:2.5.1.22]
123484426  S-methyl-5'-thioadenosine phosphorylase-like [KO:K00772] [EC:2.4.2.28]
121556754  S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
121557059  S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
121536306  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
121534343  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
121546405  methylthioribulose-1-phosphate dehydratase isoform X1 [KO:K08964] [EC:4.2.1.109]
121582779  enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
121574150  enolase-phosphatase E1-like [KO:K09880] [EC:3.1.3.77]
121545044  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
121531815  tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
121576697  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
121532047  LOW QUALITY PROTEIN: L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
121565117  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121567622  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
121539682  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
121569069  dnmt1; LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
121539590  DNA (cytosine-5)-methyltransferase 3A isoform X5 [KO:K17398] [EC:2.1.1.37]
121552431  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
121544650  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121545504  uncharacterized protein LOC121545504 [KO:K17399] [EC:2.1.1.37]
121545506  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
121545683  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17399] [EC:2.1.1.37]
121538067  uncharacterized protein LOC121538067 isoform X1 [KO:K17399] [EC:2.1.1.37]
121538175  DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
121546249  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
121532186  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121575286  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
121575601  adenosylhomocysteinase B [KO:K01251] [EC:3.13.2.1]
121543682  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
121577210  putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]
121577644  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121578306  adenosylhomocysteinase B [KO:K01251] [EC:3.13.2.1]
121537716  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121546136  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
121575696  branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
121543633  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
121568925  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
121551371  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
121573417  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121547141  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
121575122  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
121540254  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
121533416  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
121538358  glutathione synthetase [KO:K21456] [EC:6.3.2.3]
121584405  cysteine dioxygenase type 1-like [KO:K00456] [EC:1.13.11.20]
121587500  cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
121547086  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
121533211  aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
121574926  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
121587347  got1l1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
121531881  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
121576635  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
121558012  got2b; glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
121555862  3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121550245  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121570587  mpst; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121546299  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
121555275  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
121531989  ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
121543731  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
121577069  L-lactate dehydrogenase B-A chain isoform X1 [KO:K00016] [EC:1.1.1.27]
121531617  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
121533178  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
121552100  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
121579383  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
121550415  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
121584175  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121530911  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121538865  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121556062  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121536798  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121530745  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
cclu00010  Glycolysis / Gluconeogenesis
cclu00250  Alanine, aspartate and glutamate metabolism
cclu00260  Glycine, serine and threonine metabolism
cclu00290  Valine, leucine and isoleucine biosynthesis
cclu00430  Taurine and hypotaurine metabolism
cclu00480  Glutathione metabolism
cclu00620  Pyruvate metabolism
cclu00640  Propanoate metabolism
cclu00770  Pantothenate and CoA biosynthesis
cclu00900  Terpenoid backbone biosynthesis
cclu00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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