KEGG   PATHWAY: cdk04972
Entry
cdk04972                    Pathway                                
Name
Pancreatic secretion - Camelus dromedarius (Arabian camel)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
cdk04972  Pancreatic secretion
cdk04972

Other DBs
GO: 0030157
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105088954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105084650  CCK; cholecystokinin [KO:K05226]
105096211  CCKAR; cholecystokinin receptor type A [KO:K04194]
105087414  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
105101292  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101500  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
105096910  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105094833  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105103265  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105087611  RAB3D; ras-related protein Rab-3D isoform X2 [KO:K07884]
105101820  RAB8A; ras-related protein Rab-8A [KO:K07901]
105093261  RAB11A; ras-related protein Rab-11A [KO:K07904]
105103590  RAB27B; ras-related protein Rab-27B [KO:K07886]
105102039  RAP1A; ras-related protein Rap-1A [KO:K04353]
105101089  RAP1B; ras-related protein Rap-1b [KO:K07836]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105085612  pancreatic alpha-amylase [KO:K01176] [EC:3.2.1.1]
105088684  anionic trypsin isoform X1 [KO:K01312] [EC:3.4.21.4]
105106781  LOW QUALITY PROTEIN: cationic trypsin [KO:K01312] [EC:3.4.21.4]
105104323  chymotrypsinogen B isoform X4 [KO:K01310] [EC:3.4.21.1]
105105250  chymotrypsinogen A [KO:K01310] [EC:3.4.21.1]
105106186  chymotrypsinogen B-like [KO:K01310] [EC:3.4.21.1]
105088480  CTRL; LOW QUALITY PROTEIN: chymotrypsin-like protease CTRL-1 [KO:K09632] [EC:3.4.21.-]
105107055  chymotrypsin-like elastase family member 2A [KO:K01346] [EC:3.4.21.71]
105088866  proproteinase E [KO:K01345] [EC:3.4.21.70]
105085388  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
105085436  CPA2; LOW QUALITY PROTEIN: carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
105089508  CPA3; LOW QUALITY PROTEIN: mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
105089516  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
105089749  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
105095102  pancreatic triacylglycerol lipase [KO:K14073] [EC:3.1.1.3]
105095101  pancreatic lipase-related protein 2 isoform X2 [KO:K14075] [EC:3.1.1.3]
105085185  CEL; bile salt-activated lipase [KO:K12298] [EC:3.1.1.13 3.1.1.3]
105088845  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
105088846  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088847  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088848  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088887  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105103971  PLA2G2E; group IIE secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105099428  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105092473  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105101999  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105089899  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105091384  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105093156  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
105102013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105101373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105088820  ryanodine receptor 2 isoform X1 [KO:K04962]
105098339  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105098338  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
105104394  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
105102781  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105095745  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105102497  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105084532  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
105084530  CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028]
105084515  calcium-activated chloride channel regulator 1 [KO:K05030]
105084517  CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030]
105086330  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
105089862  SLC12A2; LOW QUALITY PROTEIN: solute carrier family 12 member 2 [KO:K10951]
116147050  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
105100141  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
105089616  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
105090227  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
105086324  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
105092738  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
105098894  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
105103012  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
105090183  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
105106340  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926]
105092432  KCNMA1; LOW QUALITY PROTEIN: calcium-activated potassium channel subunit alpha-1 [KO:K04936]
105103904  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105104496  ATP2B4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
105093111  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105094859  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105100703  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105105652  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
105088539  SCTR; secretin receptor isoform X1 [KO:K04588]
105095656  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
105095655  neuroendocrine secretory protein 55 [KO:K04632]
105095715  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105094039  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105100030  ADCY3; adenylate cyclase type 3 isoform X5 [KO:K08043] [EC:4.6.1.1]
105102432  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105090284  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105103816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105097528  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105096450  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
105099828  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105085325  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
105093041  SLC26A3; chloride anion exchanger [KO:K14078]
105091193  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X3 [KO:K13575]
105088502  CA2; carbonic anhydrase 2 [KO:K18245] [EC:4.2.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
cdk04020  Calcium signaling pathway
cdk04530  Tight junction
cdk04973  Carbohydrate digestion and absorption
cdk04974  Protein digestion and absorption
cdk04975  Fat digestion and absorption
cdk04977  Vitamin digestion and absorption
KO pathway
ko04972   
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