KEGG   PATHWAY: cdk04020
Entry
cdk04020                    Pathway                                
Name
Calcium signaling pathway - Camelus dromedarius (Arabian camel)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cdk04020  Calcium signaling pathway
cdk04020

Other DBs
GO: 0019722
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105084220  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105084245  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105084385  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105084416  VEGFC; vascular endothelial growth factor C [KO:K05449]
105084439  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105084810  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
105085024  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105085087  ADORA2B; adenosine receptor A2b [KO:K04267]
105085135  DRD5; D(1B) dopamine receptor [KO:K05840]
105085321  [KO:K05099] [EC:2.7.10.1]
105085458  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
105086379  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105086434  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105086482  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
105086549  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105086584  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105086750  TFEB; transcription factor EB [KO:K15590]
105086908  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
105086987  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105087057  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105087412  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
105087414  [KO:K04634]
105087559  [KO:K04992]
105087596  MST1R; macrophage-stimulating protein receptor isoform X4 [KO:K05100] [EC:2.7.10.1]
105087650  MST1; hepatocyte growth factor-like protein [KO:K23441]
105087834  TNNC2; troponin C, skeletal muscle [KO:K12042]
105087896  [KO:K04282]
105088198  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105088346  PLN; cardiac phospholamban [KO:K05852]
105088479  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105088633  VEGFA; vascular endothelial growth factor A [KO:K05448]
105088820  [KO:K04962]
105088937  TGFA; protransforming growth factor alpha [KO:K08774]
105088954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105089056  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105089267  AVPR1A; vasopressin V1a receptor [KO:K04226]
105089379  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105089440  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
105089509  AGTR1; type-1 angiotensin II receptor [KO:K04166]
105089570  TACR3; neuromedin-K receptor [KO:K04224]
105089593  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105089621  CASQ2; calsequestrin-2 [KO:K23445]
105089623  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105089705  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
105089744  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
105089905  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105089916  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
105089947  ADRB3; beta-3 adrenergic receptor [KO:K04143]
105089979  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105090026  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
105090094  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
105090242  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105090282  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105090726  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
105090819  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105090835  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105091170  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
105091178  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105091204  EDNRA; endothelin-1 receptor [KO:K04197]
105091325  FGF6; fibroblast growth factor 6 [KO:K04358]
105091333  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
105091516  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105091598  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105091619  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105091789  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105091934  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105091987  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105092074  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
105092188  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105092280  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105092345  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105092350  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
105092364  CALM2; calmodulin-2 [KO:K02183]
105092379  ORAI2; protein orai-2 isoform X2 [KO:K16057]
105092427  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105092440  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105092453  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105092463  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105092475  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105092504  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105093108  HRH1; histamine H1 receptor [KO:K04149]
105093111  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105093156  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
105093176  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105093178  OXTR; oxytocin receptor [KO:K04229]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105093291  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
105093350  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
105093410  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105093420  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105093669  FGF2; fibroblast growth factor 2 [KO:K18497]
105093679  C2H4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
105093754  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
105093848  MRLN; myoregulin [KO:K22643]
105093932  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
105093951  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
105094039  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105094408  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
105094833  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105094859  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105094989  GRPR; gastrin-releasing peptide receptor [KO:K04169]
105095035  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105095048  MCOLN2; mucolipin-2 isoform X2 [KO:K04993]
105095049  MCOLN3; mucolipin-3 isoform X3 [KO:K04994]
105095191  ADORA2A; adenosine receptor A2a [KO:K04266]
105095226  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
105095388  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
105095501  BDKRB2; B2 bradykinin receptor [KO:K03916]
105095510  BDKRB1; B1 bradykinin receptor [KO:K03915]
105095567  FGF16; fibroblast growth factor 16 [KO:K04358]
105095655  [KO:K04632]
105095656  [KO:K04632]
105095698  NTSR1; neurotensin receptor type 1 [KO:K04211]
105095715  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105095744  P2RX1; P2X purinoceptor 1 [KO:K05215]
105095745  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105095750  P2RX5; P2X purinoceptor 5 isoform X5 [KO:K05219]
105095855  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
105096001  CALM1; calmodulin-1 [KO:K02183]
105096051  ADRA1D; LOW QUALITY PROTEIN: alpha-1D adrenergic receptor [KO:K04137]
105096083  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
105096211  CCKAR; cholecystokinin receptor type A [KO:K04194]
105096212  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
105096253  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
105096268  TACR1; substance-P receptor [KO:K04222]
105096404  FGF9; LOW QUALITY PROTEIN: fibroblast growth factor 9 [KO:K04358]
105096450  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
105096497  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
105096529  STIM1; stromal interaction molecule 1 isoform X4 [KO:K16059]
105096536  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105096638  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
105096669  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
105096854  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
105096910  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105096948  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
105097010  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105097013  ADRB2; beta-2 adrenergic receptor [KO:K04142]
105097528  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105097747  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105097920  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
105098071  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
105098275  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105098339  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105098361  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
105098484  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105098486  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105098585  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
105098664  AVPR1B; vasopressin V1b receptor [KO:K04227]
105098814  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
105098943  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
105098957  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105099069  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105099333  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
105099582  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105099620  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
105099828  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105099881  TACR2; substance-K receptor [KO:K04223]
105099901  ADRA1B; LOW QUALITY PROTEIN: alpha-1B adrenergic receptor [KO:K04136]
105100030  ADCY3; adenylate cyclase type 3 isoform X5 [KO:K08043] [EC:4.6.1.1]
105100139  CASQ1; calsequestrin-1 [KO:K23468]
105100214  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
105100308  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
105100369  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105100399  VEGFD; vascular endothelial growth factor D [KO:K05449]
105100473  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105100622  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105100748  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105100776  [KO:K04345] [EC:2.7.11.11]
105100784  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105100824  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
105100875  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105100999  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105101177  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105101234  P2RX3; P2X purinoceptor 3 [KO:K05217]
105101292  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105101500  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101542  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105101545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
105101801  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
105101939  HRH2; histamine H2 receptor [KO:K04150]
105101941  DRD1; D(1A) dopamine receptor [KO:K04144]
105102013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105102061  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105102103  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105102240  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105102306  ADRA1A; alpha-1A adrenergic receptor isoform X2 [KO:K04135]
105102396  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105102432  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105102434  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
105102444  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
105102497  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105102501  P2RX7; P2X purinoceptor 7 [KO:K05220]
105102503  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
105102512  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
105102643  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105102653  TBXA2R; thromboxane A2 receptor [KO:K04264]
105102663  GNA15; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
105102699  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
105102722  ORAI3; protein orai-3 [KO:K16058]
105102728  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
105102781  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105102821  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105102881  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
105102899  FGF21; fibroblast growth factor 21 [KO:K22429]
105102906  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105102978  [KO:K06856]
105103090  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105103153  EDNRB; endothelin receptor type B [KO:K04198]
105103265  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105103284  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105103323  PTAFR; platelet-activating factor receptor [KO:K04279]
105103333  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105103660  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
105103850  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105103904  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105103975  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105104026  CALM3; calmodulin-3 [KO:K02183]
105104060  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
105104095  P2RX2; LOW QUALITY PROTEIN: P2X purinoceptor 2 [KO:K05216]
105104134  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105104257  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105104394  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
105104468  FGF4; fibroblast growth factor 4 [KO:K04358]
105104469  FGF19; fibroblast growth factor 19 [KO:K22603]
105104496  ATP2B4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
105104648  SMIM6; small integral membrane protein 6 [KO:K26468]
105104658  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105104750  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
105104761  FGF7; fibroblast growth factor 7 [KO:K04358]
105104911  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
105104932  TPCN1; two pore calcium channel protein 1 [KO:K16896]
105105081  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
105105270  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105105672  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105105831  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105106041  GNA11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105106183  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105106629  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
105107148  FGF10; fibroblast growth factor 10 [KO:K04358]
116147086  [KO:K02183]
116147126  [KO:K04992]
116147150  TRDN; triadin [KO:K23449]
116148424  PTGER1; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP1 subtype [KO:K04258]
116151844  [KO:K06856]
116152568  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116152984  [KO:K04161]
116153639  [KO:K06856]
116155424  PDGFD; platelet-derived growth factor D [KO:K05450]
116157091  [KO:K04358]
116157512  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cdk04010  MAPK signaling pathway
cdk04070  Phosphatidylinositol signaling system
cdk04210  Apoptosis
cdk04720  Long-term potentiation
cdk04730  Long-term depression
KO pathway
ko04020   

DBGET integrated database retrieval system