KEGG   PATHWAY: cit04141
Entry
cit04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Citrus sinensis (Valencia orange)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
cit04141  Protein processing in endoplasmic reticulum
cit04141

Other DBs
GO: 0030433 0034976
Organism
Citrus sinensis (Valencia orange) [GN:cit]
Gene
102625854  uncharacterized protein LOC102625854 [KO:K10956]
102616382  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
102609105  uncharacterized protein LOC102609105 [KO:K10956]
102621509  protein transport protein Sec61 subunit beta isoform X2 [KO:K09481]
102612513  protein transport protein Sec61 subunit beta [KO:K09481]
102612236  protein transport protein Sec61 subunit gamma [KO:K07342]
102629817  uncharacterized protein LOC102629817 [KO:K12275]
102609148  DnaJ protein ERDJ2A-like [KO:K09540]
102628036  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
102625752  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
102609203  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
102618059  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
102608102  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
102618847  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit isoform X1 [KO:K12670]
102610458  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
102614913  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
102629722  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
102614820  uncharacterized protein LOC102614820 [KO:K26501]
102611285  uncharacterized protein LOC102611285 [KO:K26502]
102626422  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
102619809  heat shock 70 kDa protein 17 [KO:K09486]
102609733  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
102621671  luminal-binding protein 5 [KO:K09490] [EC:3.6.4.10]
102611983  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
102629863  luminal-binding protein 5-like [KO:K09490] [EC:3.6.4.10]
102623924  heat shock 70 kDa protein BIP3-like [KO:K09490] [EC:3.6.4.10]
102629298  DnaJ protein ERDJ3B [KO:K09517]
102630768  DnaJ protein P58IPK homolog [KO:K09523]
102611150  heat shock protein 90-6, mitochondrial [KO:K09487]
102629966  heat shock protein 90-5, chloroplastic [KO:K09487]
102608412  endoplasmin homolog [KO:K09487]
102611800  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
102627402  glucosidase 2 subunit beta [KO:K08288]
102629392  calnexin homolog 1-like isoform X2 [KO:K08054]
102617406  calnexin homolog [KO:K08054]
102618403  calreticulin [KO:K08057]
102611212  calreticulin-3-like isoform X1 [KO:K08057]
102608719  calreticulin-3 isoform X2 [KO:K08057]
102615170  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
102616435  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 isoform X1 [KO:K23741] [EC:3.2.1.209]
102629777  SEC12-like protein 1 [KO:K14003]
102609923  SEC12-like protein 2 [KO:K14003]
102617360  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
102626272  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
102625214  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
102625491  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
102631283  protein transport protein SEC13 homolog B-like [KO:K14004]
102613333  protein transport protein SEC13 homolog B-like [KO:K14004]
102611220  protein transport protein SEC31 homolog B isoform X1 [KO:K14005]
102628456  protein transport protein SEC23 [KO:K14006]
102614305  protein transport protein SEC23 [KO:K14006]
102619674  protein transport protein SEC23-like [KO:K14006]
102619797  protein transport protein Sec24-like At3g07100 [KO:K14007]
102609457  protein transport protein Sec24-like At4g32640 [KO:K14007]
102612429  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
102628233  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
102612522  alpha-mannosidase I MNS4 [KO:K10085]
102614761  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
102626480  protein disulfide isomerase-like 1-3 isoform X2 [KO:K09580] [EC:5.3.4.1]
102609645  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
102621553  protein disulfide-isomerase 5-2 isoform X1 [KO:K09580] [EC:5.3.4.1]
102629426  protein disulfide isomerase-like 1-4 isoform X1 [KO:K09580] [EC:5.3.4.1]
102619136  protein disulfide isomerase-like 1-3 isoform X1 [KO:K09580] [EC:5.3.4.1]
107174884  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
112496592  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
102627665  protein disulfide-isomerase like 2-1 [KO:K09584] [EC:5.3.4.1]
102609257  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
102621155  endoplasmic reticulum oxidoreductin-2-like isoform X2 [KO:K10950] [EC:1.8.4.-]
102629390  endoplasmic reticulum oxidoreductin-1 isoform X1 [KO:K10950] [EC:1.8.4.-]
102608312  protein OS-9 homolog [KO:K10088]
102618850  translocon-associated protein subunit alpha [KO:K13249]
102615464  uncharacterized protein LOC102615464 [KO:K13250]
102623106  uncharacterized protein LOC102623106 isoform X3 [KO:K14009]
102609110  uncharacterized protein LOC102609110 [KO:K14009]
102629814  uncharacterized protein LOC102629814 [KO:K14009]
102611922  derlin-2.2 [KO:K13989]
102628727  derlin-1 [KO:K13989]
102621067  derlin-1-like [KO:K13989]
102615084  uncharacterized protein LOC102615084 [KO:K24348]
102624265  plant UBX domain-containing protein 2 [KO:K14011]
102613799  plant UBX domain-containing protein 4 [KO:K14012]
102619456  plant UBX domain-containing protein 4 [KO:K14012]
102630724  cell division cycle protein 48 homolog [KO:K13525]
102612408  cell division cycle protein 48 homolog [KO:K13525]
102609758  cell division cycle protein 48 homolog isoform X1 [KO:K13525]
102611590  cell division cycle protein 48 homolog [KO:K13525]
102620569  NPL4-like protein 1 [KO:K14015]
102626115  uncharacterized protein LOC102626115 [KO:K14016]
102625489  uncharacterized protein LOC102625489 isoform X1 [KO:K14016]
102610628  uncharacterized protein LOC102610628 isoform X1 [KO:K14016]
102606928  stromal 70 kDa heat shock-related protein, chloroplastic isoform X1 [KO:K03283]
102615530  heat shock cognate 70 kDa protein [KO:K03283]
102626809  heat shock 70 kDa protein 1 [KO:K03283]
102609521  heat shock cognate 70 kDa protein 2-like isoform X1 [KO:K03283]
102625591  heat shock 70 kDa protein 5 [KO:K03283]
102617797  heat shock 70 kDa protein 18-like [KO:K03283]
102617514  heat shock 70 kDa protein 1 [KO:K03283]
112495491  heat shock 70 kDa protein 6, chloroplastic [KO:K03283]
102619093  heat shock 70 kDa protein [KO:K03283]
102611703  chaperone protein DnaJ A6 [KO:K09503]
102627308  DnaJ protein homolog ANJ1 [KO:K09503]
102608938  DnaJ protein homolog [KO:K09503]
102625062  chaperone protein DnaJ 49-like [KO:K09518]
102612711  chaperone protein DnaJ 49 [KO:K09518]
102578032  HSP90; HSP90 protein [KO:K04079]
102628301  heat shock protein 83 [KO:K04079]
102616579  heat shock protein 83-like [KO:K04079]
102608627  hsp70 nucleotide exchange factor fes1 [KO:K09562]
102625711  hsp70 nucleotide exchange factor FES1 isoform X1 [KO:K09562]
102624529  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
102612820  15.4 kDa class V heat shock protein [KO:K13993]
102627015  17.4 kDa class III heat shock protein [KO:K13993]
102624423  LOW QUALITY PROTEIN: 15.7 kDa heat shock protein, peroxisomal [KO:K13993]
102610711  small heat shock protein, chloroplastic-like [KO:K13993]
102624989  class I heat shock protein-like [KO:K13993]
102630544  22.0 kDa heat shock protein [KO:K13993]
102622920  class I heat shock protein-like [KO:K13993]
102617422  17.6 kDa class I heat shock protein-like [KO:K13993]
102608585  small heat shock protein, chloroplastic [KO:K13993]
102612271  heat shock 22 kDa protein, mitochondrial [KO:K13993]
102624698  18.1 kDa class I heat shock protein-like [KO:K13993]
102630706  heat shock 22 kDa protein, mitochondrial-like [KO:K13993]
102631003  heat shock 22 kDa protein, mitochondrial [KO:K13993]
102626248  17.4 kDa class I heat shock protein-like [KO:K13993]
102613214  17.4 kDa class I heat shock protein-like [KO:K13993]
102620028  17.3 kDa class I heat shock protein-like [KO:K13993]
102620759  17.3 kDa class I heat shock protein-like [KO:K13993]
102621053  18.2 kDa class I heat shock protein [KO:K13993]
102621322  17.3 kDa class I heat shock protein-like [KO:K13993]
102621606  18.1 kDa class I heat shock protein [KO:K13993]
102606859  17.3 kDa class II heat shock protein-like [KO:K13993]
102608313  17.7 kDa class II heat shock protein [KO:K13993]
102621754  18.1 kDa class I heat shock protein [KO:K13993]
102617602  18.1 kDa class I heat shock protein-like [KO:K13993]
107177751  17.1 kDa class II heat shock protein-like [KO:K13993]
102608024  17.9 kDa class II heat shock protein-like [KO:K13993]
107176422  18.5 kDa class IV heat shock protein [KO:K13993]
102630611  small heat shock protein, chloroplastic isoform X1 [KO:K13993]
112496442  22.7 kDa class IV heat shock protein-like isoform X1 [KO:K13993]
127902083  22.7 kDa class IV heat shock protein-like [KO:K13993]
127902339  22.7 kDa class IV heat shock protein-like [KO:K13993]
102610987  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
102620389  uncharacterized protein LOC102620389 isoform X1 [KO:K14018]
102614644  ubiquitin receptor RAD23c-like isoform X1 [KO:K10839]
102610300  ubiquitin receptor RAD23d-like [KO:K10839]
102620700  ubiquitin receptor RAD23b [KO:K10839]
102628282  ubiquitin domain-containing protein DSK2b-like [KO:K04523]
102606837  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [KO:K01456] [EC:3.5.1.52]
102608142  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
102621796  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
102615936  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
102618142  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
102620118  membrane-bound transcription factor site-2 protease homolog isoform X1 [KO:K07765] [EC:3.4.24.85]
102612008  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102626183  serine/threonine-protein kinase/endoribonuclease IRE1b isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102617124  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
102621055  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
102618560  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
102607489  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
102615059  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
102610175  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
102622440  uncharacterized protein LOC102622440 [KO:K10666] [EC:2.3.2.27]
102620748  E3 ubiquitin-protein ligase RMA3 [KO:K10666] [EC:2.3.2.27]
102629340  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
102619686  uncharacterized protein LOC102619686 [KO:K10666] [EC:2.3.2.27]
102626834  uncharacterized protein LOC102626834 isoform X4 [KO:K10666] [EC:2.3.2.27]
102626072  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
102629805  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
102617305  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
102611214  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
102623736  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
102625059  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
102608974  ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [KO:K06689] [EC:2.3.2.23]
127898580  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
127898619  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
102614401  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
102630275  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
102622192  uncharacterized protein LOC102622192 [KO:K03868] [EC:2.3.2.32]
102613162  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
102612067  cullin-1 [KO:K03347]
102625018  cullin-1 [KO:K03347]
102609911  SKP1-like protein 1A [KO:K03094]
102615892  SKP1-like protein 1B [KO:K03094]
102623092  SKP1-like protein 1 [KO:K03094]
102625199  SKP1-like protein 1B [KO:K03094]
102627825  SKP1-like protein 14 [KO:K03094]
112495875  SKP1-like protein 11 [KO:K03094]
112496330  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
cit00510  N-Glycan biosynthesis
cit03050  Proteasome
cit03060  Protein export
KO pathway
ko04141   
LinkDB

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