KEGG   PATHWAY: cmao00260
Entry
cmao00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Colossoma macropomum (tambaqui)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cmao00260  Glycine, serine and threonine metabolism
cmao00260

Module
cmao_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cmao00260]
cmao_M00047  Creatine pathway [PATH:cmao00260]
cmao_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cmao00260]
cmao_M00555  Betaine biosynthesis, choline => betaine [PATH:cmao00260]
cmao_M00621  Glycine cleavage system [PATH:cmao00260]
cmao_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cmao00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118809372  tha1; threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
118805704  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
118808470  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
118808050  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
118804733  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
118816499  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
118807281  grhpra; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
118808572  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
118798077  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
118810407  pgam1a; phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
118820383  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
118806774  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
118807050  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
118826893  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
118797294  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
118821373  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
118823601  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
118823950  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
118815506  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
118800392  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
118813747  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
118817391  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
118824443  si:ch211-127i16.2; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
118820931  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
118826940  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
118813671  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
118811721  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
118817710  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
118819382  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
118826894  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
118820452  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
118803992  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
118818792  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
118813384  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
118824520  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118820406  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
118819648  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
118801289  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
118824921  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
118823180  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
118797906  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
118801748  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
118808299  cbsb; cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
118808211  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
118810651  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
118824011  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
118827027  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
118818925  zgc:162816; LOW QUALITY PROTEIN: D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cmao00010  Glycolysis / Gluconeogenesis
cmao00020  Citrate cycle (TCA cycle)
cmao00230  Purine metabolism
cmao00250  Alanine, aspartate and glutamate metabolism
cmao00270  Cysteine and methionine metabolism
cmao00290  Valine, leucine and isoleucine biosynthesis
cmao00330  Arginine and proline metabolism
cmao00470  D-Amino acid metabolism
cmao00564  Glycerophospholipid metabolism
cmao00600  Sphingolipid metabolism
cmao00620  Pyruvate metabolism
cmao00630  Glyoxylate and dicarboxylate metabolism
cmao00640  Propanoate metabolism
cmao00860  Porphyrin metabolism
cmao00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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