Entry
Name
Lysosome - Colossoma macropomum (tambaqui)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Colossoma macropomum (tambaqui) [GN:
cmao ]
Gene
118798543 si:ch73-173p19.2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a1 [KO:K02154 ]
118810535 tcirg1a; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154 ]
118800432 atp6v0a1b; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
118807316 tcirg1b; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b isoform X1 [KO:K02154 ]
118824963 atp6v0a2a; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154 ]
118827199 atp6v0a2b; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154 ]
118821847 atp6v0a1a; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
118822770 atp6ap1a; ATPase H+ transporting accessory protein 1a [KO:K03662 ]
118814794 atp6v0cb; LOW QUALITY PROTEIN: ATPase H+ transporting V0 subunit cb [KO:K02155 ]
118825743 atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
118823325 si:ch211-15d5.11; LOW QUALITY PROTEIN: oxidation resistance protein 1 [KO:K25442 ]
118816948 asah1b; LOW QUALITY PROTEIN: N-acylsphingosine amidohydrolase (acid ceramidase) 1b [KO:K12348 ] [EC:3.5.1.23 ]
118799471 slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398 ]
118803063 natural resistance-associated macrophage protein 2-like [KO:K21398 ]
118800449 lysosomal-associated transmembrane protein 4B-like isoform X1 [KO:K12387 ]
118805479 laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
118815719 laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
118827179 abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
118803600 cln5; ceroid-lipofuscinosis neuronal protein 5 homolog [KO:K12390 ]
118819554 mfsd8l1; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
118826205 mfsd8l2; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
118809223 mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
118822349 gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087 ]
118815740 igf2r; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564 ]
118808179 ap1m3; adaptor related protein complex 1 subunit mu 3 [KO:K12393 ]
118808136 gga3a; ADP-ribosylation factor-binding protein GGA3a isoform X1 [KO:K12404 ]
118805749 litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
118805775 snrnp25; U11/U12 small nuclear ribonucleoprotein 25 kDa protein isoform X1 [KO:K19363 ]
118798100 si:dkeyp-75b4.8; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363 ]
118798112 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
118798113 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
118821504 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Related pathway
cmao04130 SNARE interactions in vesicular transport
KO pathway
LinkDB
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