KEGG   PATHWAY: cmao04140
Entry
cmao04140                   Pathway                                
Name
Autophagy - animal - Colossoma macropomum (tambaqui)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
cmao04140  Autophagy - animal
cmao04140

Other DBs
GO: 0006914
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118796927  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
118796950  rab8a; ras-related protein Rab-8A [KO:K07901]
118796986  atg5; autophagy protein 5 isoform X1 [KO:K08339]
118796994  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118797159  [KO:K08803] [EC:2.7.11.1]
118797185  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
118797244  sh3glb1b; endophilin-B1b isoform X1 [KO:K11248]
118797821  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118798122  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
118798163  atg4da; cysteine protease ATG4D [KO:K08342] [EC:3.4.22.-]
118798193  smcr8b; guanine nucleotide exchange protein smcr8b [KO:K23611]
118798267  tsc2; tuberin isoform X1 [KO:K07207]
118798278  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118798413  irs2a; insulin receptor substrate 2a [KO:K07187]
118798524  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
118798619  stx17; syntaxin-17 [KO:K08491]
118798671  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
118798903  irs1; insulin receptor substrate 1-B [KO:K16172]
118799162  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
118799170  si:ch211-11n16.2; zinc finger FYVE domain-containing protein 1 [KO:K17603]
118799275  si:dkey-13a21.4; LOW QUALITY PROTEIN: ras-related protein rab7 [KO:K07897]
118799278  rab7a; ras-related protein Rab-7a [KO:K07897]
118799312  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118799424  prkcdb; protein kinase C, delta b isoform X1 [KO:K06068] [EC:2.7.11.13]
118799451  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118799506  atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
118799814  vmp1; vacuole membrane protein 1 [KO:K21248]
118799827  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
118799875  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
118800009  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
118800114  rab1aa; RAB1A, member RAS oncogene family a [KO:K07874]
118800505  rras; ras-related protein R-Ras [KO:K07830]
118800533  [KO:K04526]
118800841  rps6kb1a; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
118800858  [KO:K21248]
118800860  hmgb1a; high mobility group protein B1a isoform X1 [KO:K10802]
118800916  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
118800919  mras; ras-related protein M-Ras [KO:K07831]
118800990  [KO:K01365] [EC:3.4.22.15]
118801580  hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268]
118801651  ins; insulin [KO:K04526]
118801967  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118802151  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118802406  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
118802426  [KO:K20868]
118803181  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
118803815  cflara; CASP8 and FADD-like apoptosis regulator a [KO:K04724]
118804594  zgc:101559; ras-related protein Rab-33B [KO:K07920]
118804672  hmgb1b; LOW QUALITY PROTEIN: high mobility group protein B1b [KO:K10802]
118805323  atg4db; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
118805373  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
118805703  smcr8a; guanine nucleotide exchange protein smcr8a [KO:K23611]
118805718  wipi2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
118805760  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
118805840  tax1bp1a; tax1-binding protein 1 homolog A [KO:K21347]
118806028  si:dkey-240h12.4; death-associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
118806091  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118806335  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
118806420  insb; preproinsulin b [KO:K04526]
118806536  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
118806541  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
118806558  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
118806824  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118806907  atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
118807315  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
118807372  rraga; ras-related GTP-binding protein A [KO:K16185]
118807805  atg9a; autophagy-related protein 9A [KO:K17907]
118807854  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
118807970  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
118808049  atg4b; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
118808081  atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
118808170  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118808278  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118808294  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
118808318  [KO:K07897]
118808398  mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
118808591  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
118808652  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
118808686  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
118808692  si:ch73-116o1.2; ras-related protein M-Ras isoform X1 [KO:K07831]
118809090  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
118809193  nrbf2b; nuclear receptor-binding factor 2b isoform X1 [KO:K21246]
118809297  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
118809466  nbr1a; NBR1 autophagy cargo receptor a [KO:K17987]
118809479  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
118809539  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
118809576  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118809603  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
118809639  becn1; beclin-1 [KO:K08334]
118809652  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118810240  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118810281  c9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
118810293  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118810448  [KO:K08270]
118810697  rab1ab; RAB1A, member RAS oncogene family b [KO:K07874]
118810782  [KO:K07920]
118811026  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
118811525  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
118811569  kras; GTPase KRas isoform X1 [KO:K07827]
118811673  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
118811891  ambra1b; LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1b [KO:K17985]
118812146  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
118812213  [KO:K04724]
118812267  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118812341  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
118812571  optn; optineurin [KO:K19946]
118813117  ulk1a; serine/threonine-protein kinase ULK1a [KO:K21357] [EC:2.7.11.1]
118813217  [KO:K08516]
118813278  rab7b; ras-related protein Rab-7b [KO:K07897]
118813484  mtmr3; LOW QUALITY PROTEIN: myotubularin-related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
118813519  snap29; synaptosomal-associated protein 29 [KO:K08509]
118813576  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
118813822  nras; GTPase NRas [KO:K07828]
118814353  atg12; ubiquitin-like protein ATG12 [KO:K08336]
118814571  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118814647  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
118814679  [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
118814757  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
118814785  ubb; polyubiquitin-B [KO:K08770]
118814956  [KO:K08341]
118814996  [KO:K01365] [EC:3.4.22.15]
118815184  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
118815329  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118815456  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118815526  hif1ab; hypoxia inducible factor 1 subunit alpha b [KO:K08268]
118815683  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
118815686  zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
118815824  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
118815880  ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
118815953  [KO:K04456] [EC:2.7.11.1]
118815998  stx7l; syntaxin-7 [KO:K08488]
118816554  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
118816608  [KO:K04688] [EC:2.7.11.1]
118816639  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
118817358  ambra1a; activating molecule in BECN1-regulated autophagy protein 1a isoform X1 [KO:K17985]
118817368  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
118817529  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
118817540  hrasb; HRas proto-oncogene, GTPase b isoform X1 [KO:K02833]
118817746  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
118818017  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118818240  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118818325  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118818647  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118818761  rras2; ras-related protein R-Ras2 [KO:K07830]
118818810  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118818821  dapk2a; death-associated protein kinase 2a [KO:K08803] [EC:2.7.11.1]
118818861  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118818887  cts12; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118818937  rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
118819018  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
118819270  [KO:K01365] [EC:3.4.22.15]
118819471  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
118819633  rragca; ras-related GTP binding Ca [KO:K16186]
118819820  [KO:K07359] [EC:2.7.11.17]
118819866  rab39ba; RAB39B, member RAS oncogene family a [KO:K07925]
118819880  wdr41; WD repeat-containing protein 41 [KO:K23610]
118819913  [KO:K01365] [EC:3.4.22.15]
118819914  [KO:K01365] [EC:3.4.22.15]
118819915  [KO:K01365] [EC:3.4.22.15]
118819916  [KO:K01365] [EC:3.4.22.15]
118819985  tsc1b; TSC complex subunit 1b [KO:K07206]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820025  atg4a; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
118820113  irs4a; insulin receptor substrate 2-B [KO:K07187]
118820198  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820416  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
118820664  bada; bcl2-associated agonist of cell death [KO:K02158]
118820924  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
118820927  wipi1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
118820974  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118821177  rheb; GTP-binding protein Rheb [KO:K07208]
118821186  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118821270  zgc:55558; GTPase HRas [KO:K07827]
118821342  nbr1b; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
118821575  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
118822077  bcl2l1; bcl-2-like protein 1 [KO:K04570]
118822140  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118822149  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118822345  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
118822617  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118822660  atg9b; autophagy-related protein 9B [KO:K17907]
118822709  rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
118822861  [KO:K21247]
118823235  eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
118823237  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118823275  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118823346  atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
118823460  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
118823535  [KO:K01365] [EC:3.4.22.15]
118823536  [KO:K01365] [EC:3.4.22.15]
118823537  [KO:K01365] [EC:3.4.22.15]
118823538  [KO:K01365] [EC:3.4.22.15]
118823540  [KO:K01365] [EC:3.4.22.15]
118823541  [KO:K01365] [EC:3.4.22.15]
118823542  [KO:K01365] [EC:3.4.22.15]
118823544  [KO:K01365] [EC:3.4.22.15]
118823545  [KO:K01365] [EC:3.4.22.15]
118823547  [KO:K01365] [EC:3.4.22.15]
118823548  [KO:K01365] [EC:3.4.22.15]
118823549  [KO:K01365] [EC:3.4.22.15]
118823550  [KO:K01365] [EC:3.4.22.15]
118823551  [KO:K01365] [EC:3.4.22.15]
118823554  [KO:K01365] [EC:3.4.22.15]
118823556  [KO:K01365] [EC:3.4.22.15]
118823557  [KO:K01365] [EC:3.4.22.15]
118823558  [KO:K01365] [EC:3.4.22.15]
118823559  [KO:K01365] [EC:3.4.22.15]
118823560  [KO:K01365] [EC:3.4.22.15]
118823569  [KO:K01365] [EC:3.4.22.15]
118823823  rragd; ras-related GTP-binding protein D [KO:K16186]
118823866  [KO:K01365] [EC:3.4.22.15]
118823923  [KO:K03237]
118824096  nrbf2a; nuclear receptor binding factor 2a [KO:K21246]
118824204  [KO:K10586] [EC:2.3.2.23]
118824226  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
118824283  supt20; transcription factor SPT20 homolog isoform X1 [KO:K21245]
118824331  atg101; autophagy-related protein 101 [KO:K19730]
118824343  wdr45; WD repeat domain phosphoinositide-interacting protein 4 [KO:K22991]
118824374  si:ch73-234b20.5; vesicle-associated membrane protein 8 [KO:K08512]
118824466  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
118824510  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
118824533  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
118824565  atg10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
118824719  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
118824744  irs2b; insulin receptor substrate 2 [KO:K07187]
118824886  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
118825520  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
118825529  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
118825617  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118825698  rab39bb; RAB39B, member RAS oncogene family b [KO:K07925]
118826264  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
118826501  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
118826580  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
118826746  [KO:K07187]
118826752  gabarapb; GABA(A) receptor-associated protein b [KO:K08341]
118826764  rab1ba; zRAB1B, member RAS oncogene family a [KO:K07874]
118826874  vamp8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
118826884  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
118827015  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
118827019  epg5; ectopic P granules protein 5 homolog [KO:K23883]
118827123  dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
118827508  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118827549  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
118827556  wdfy3; LOW QUALITY PROTEIN: WD repeat and FYVE domain-containing protein 3 [KO:K22262]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
cmao04010  MAPK signaling pathway
cmao04141  Protein processing in endoplasmic reticulum
cmao04142  Lysosome
cmao04150  mTOR signaling pathway
cmao04910  Insulin signaling pathway
KO pathway
ko04140   

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