Entry
Name
Adherens junction - Colossoma macropomum (tambaqui)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Colossoma macropomum (tambaqui) [GN:
cmao ]
Gene
118805928 pvrl2l; PVR cell adhesion molecule related 2 like isoform X1 [KO:K06531 ]
118796697 pard3ab; par-3 family cell polarity regulator alpha, b isoform X1 [KO:K04237 ]
118808053 farp2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082 ]
118799432 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
118809795 rac3b; ras-related C3 botulinum toxin substrate 3b isoform X1 [KO:K07861 ]
118811730 wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612 ]
118812660 waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612 ]
118813206 wasb; LOW QUALITY PROTEIN: WASP actin nucleation promoting factor b [KO:K05747 ]
118820303 zgc:158689; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 [KO:K05627 ]
118809084 baiap2b; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627 ]
118821455 baiap2a; brain-specific angiogenesis inhibitor 1-associated protein 2a isoform X1 [KO:K05627 ]
118815884 wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753 ]
118805621 wiskott-Aldrich syndrome protein family member 2-like [KO:K05748 ]
118798743 wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083 ]
118826469 zgc:109889; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
118820447 si:ch73-362m14.4; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
118815110 wasf3a; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
118800112 si:ch211-286b5.4; afadin- and alpha-actinin-binding protein [KO:K06085 ]
118826316 ssx2ipa; synovial sarcoma, X breakpoint 2 interacting protein a isoform X1 [KO:K06085 ]
118810578 sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086 ]
118816927 si:dkey-239n17.4; mothers against decapentaplegic homolog 4 [KO:K04501 ]
118825297 smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501 ]
118805292 si:dkey-222b8.1; mothers against decapentaplegic homolog 4 [KO:K04501 ]
118815502 ccm2; cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416 ]
118802333 radil; ras-associating and dilute domain-containing protein [KO:K26418 ]
118809514 si:ch211-176g6.2; LOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein [KO:K26418 ]
118821770 si:ch73-281f12.4; RA_Radil_like and Myo5p-like_CBD_Rasip1 domain-containing protein [KO:K26418 ]
118815460 arhgap29a; rho GTPase-activating protein 29 isoform X1 [KO:K20644 ]
118797147 arhgap29b; rho GTPase-activating protein 29 isoform X1 [KO:K20644 ]
118812921 myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351 ]
118812877 myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
118824553 myl10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756 ]
118796963 myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756 ]
118826508 myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757 ]
118820914 mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758 ]
118809707 mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758 ]
Reference
Authors
Nelson WJ, Nusse R.
Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
Journal
Reference
Authors
Potter E, Bergwitz C, Brabant G.
Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
Journal
Reference
Authors
Beavon IR.
Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
Journal
Reference
Authors
Reynolds AB, Roczniak-Ferguson A.
Title
Emerging roles for p120-catenin in cell adhesion and cancer.
Journal
Reference
Authors
Angst BD, Marcozzi C, Magee AI.
Title
The cadherin superfamily: diversity in form and function.
Journal
J Cell Sci 114:629-41 (2001)
Reference
Authors
Lilien J, Balsamo J, Arregui C, Xu G.
Title
Turn-off, drop-out: functional state switching of cadherins.
Journal
Reference
Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
Journal
Reference
Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
Journal
Reference
Authors
Ciruna B, Rossant J.
Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
Journal
Reference
Authors
Peinado H, Quintanilla M, Cano A.
Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
Journal
Reference
Authors
Labbe E, Letamendia A, Attisano L.
Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
Journal
Reference
Authors
Nakanishi H, Takai Y.
Title
Roles of nectins in cell adhesion, migration and polarization.
Journal
Reference
Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title
Roles and modes of action of nectins in cell-cell adhesion.
Journal
Related pathway
cmao04060 Cytokine-cytokine receptor interaction
KO pathway
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