KEGG ORTHOLOGY: K06593

ORTHOLOGY: K06593

Entry

K06593                      KO

Symbol

NECTIN4, PVRL4

Name

poliovirus receptor-related 4

Pathway

map03265

Virion - Ebolavirus, Lyssavirus and Morbillivirus

map04517

IgSF CAM signaling

map04520

Adherens junction

Disease

H00647

Ectodermal dysplasia-syndactyly syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09125 Information processing in viruses
   03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
    K06593  NECTIN4, PVRL4; poliovirus receptor-related 4
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    K06593  NECTIN4, PVRL4; poliovirus receptor-related 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K06593  NECTIN4, PVRL4; poliovirus receptor-related 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04515 Cell adhesion molecules
    K06593  NECTIN4, PVRL4; poliovirus receptor-related 4
Cell adhesion molecules [BR:ko04515]
Immunoglobulin superfamily
  Nectin family
   K06593  NECTIN4, PVRL4; poliovirus receptor-related 4

Genes

HSA:	81607(NECTIN4)

PTR:	100610618(NECTIN4)

PPS:	100983947(NECTIN4)

GGO:	101149789(NECTIN4)

PON:	100435072(NECTIN4)

PPYG:

129006107(NECTIN4)

NLE:	100598527(NECTIN4)

HMH:	116473351(NECTIN4)

SSYN:

134734462(NECTIN4)

MCC:	719843(NECTIN4)

MCF:	102127936(NECTIN4)

MTHB:

126936945

MNI:	105498195(NECTIN4)

CSAB:

103223699

CATY:

105589259(PVRL4)

PANU:

101026258(NECTIN4)

TGE:	112629902(NECTIN4)

MLEU:

105536866(PVRL4)

RRO:	104665330(NECTIN4)

RBB:	108521191(NECTIN4)

TFN:	117074387(NECTIN4)

PTEH:

111544000(NECTIN4)

CANG:

105522948(PVRL4)

CJC:	100410291(NECTIN4)

SBQ:	101046249(PVRL4)

CIMI:

108293588(NECTIN4)

ANAN:

105715322(NECTIN4)

CSYR:

103268355(NECTIN4)

MMUR:

105873536(NECTIN4)

LCAT:

123635208(NECTIN4)

ERUF:

138389830(NECTIN4)

PCOQ:

105806419(PVRL4)

OGA:	100952695(NECTIN4)

MMU:	71740(Nectin4)

MCAL:

110302309(Nectin4)

MPAH:

110321910(Nectin4)

RNO:	498281(Nectin4)

MCOC:

116103455(Nectin4)

ANU:	117721957(Nectin4)

ASYL:

127697508(Nectin4)

MUN:	110554419(Nectin4)

CGE:	100765550(Nectin4)

MAUA:

101833659(Nectin4)

PROB:

127223581(Nectin4)

PLEU:

114685409(Nectin4)

PMAV:

102914480(Nectin4)

MORG:

121442065(Nectin4) 121455202

MFOT:

126502248

AAMP:

119827953(Nectin4)

CNL:	130874711(Nectin4)

NGI:	103745963(Nectin4)

HGL:	101710379(Nectin4)

CPOC:

100734333(Nectin4)

CCAN:

109693183(Nectin4)

DORD:

105996469(Pvrl4)

DSP:	122109685(Nectin4)

DMER:

138812221(Nectin4)

PLOP:

125359224(Nectin4)

NCAR:

124966360

SVUL:

306656472(NECTIN4)

MMMA:

107147482(Nectin4)

ITI:	101959215(Nectin4)

SCIL:

308656935(NECTIN4)

MAVE:

308259455(NECTIN4)

OCU:

100348580

OPI:	101520833(NECTIN4)

OCZ:	121171522(NECTIN4)

TUP:	102496511(NECTIN4)

GVR:	103596566(PVRL4)

CFA:	609931(NECTIN4)

CLUD:

112643012(NECTIN4)

VVP:	112910059(NECTIN4)

VLG:	121501366(NECTIN4)

NPO:	129515207(NECTIN4)

AML:	100484648(NECTIN4)

UMR:	103672110(NECTIN4)

UAH:	113246661(NECTIN4)

UAR:	123783704(NECTIN4)

ELK:

111138948

LLV:

125086305

MPUF:

101694114(PVRL4)

MNP:	132025761(NECTIN4)

MLK:	131814979(NECTIN4)

NVS:	122918361(NECTIN4)

MMAQ:

308356076(NECTIN4)

ORO:	101363552(PVRL4)

EJU:	114199186(NECTIN4)

ZCA:	113932840(NECTIN4)

MLX:	118013998(NECTIN4)

MANO:

123845866(NECTIN4)

NSU:	110573526(NECTIN4)

LWW:	102735113(NECTIN4)

FCA:	101092485(NECTIN4)

PYU:	121015490(NECTIN4)

PCOO:

112851627(NECTIN4)

PBG:	122476249(NECTIN4)

PVIV:

125155023(NECTIN4)

LRUF:

124521633

LGF:	123586250(NECTIN4)

AJU:

106978547

PTG:	102964288(NECTIN4)

PPAD:

109257259(NECTIN4)

PUC:

125925821

PLEZ:

122211440(NECTIN4)

HHV:	120241360(NECTIN4)

CCRU:

144228213(NECTIN4)

BTA:	507718(NECTIN4)

BOM:	102270831(NECTIN4)

BIU:	109556668(NECTIN4)

BJV:	133238078(NECTIN4)

BBUB:

102403825(NECTIN4)

BKE:	129655923(NECTIN4)

BBIS:

104984057(PVRL4)

CHX:	102171560(NECTIN4)

OAS:	101123428(NECTIN4)

OCAN:

138416923(NECTIN4)

BTAX:

128045508(NECTIN4)

CSUM:

138074308(NECTIN4)

ODA:	120855557(NECTIN4)

CCAD:

122430547(NECTIN4)

MREE:

136160913(NECTIN4)

OVR:	110134651(NECTIN4)

MBEZ:

129540927(NECTIN4)

SSC:	100154054(NECTIN4)

CFR:	102521028(NECTIN4)

CBAI:

105069538(PVRL4)

CDK:	105100119(NECTIN4)

VPC:	102526405(NECTIN4)

BACU:

103018646(NECTIN4)

BMUS:

118899627(NECTIN4)

LVE:	103080632(PVRL4)

OOR:	101281550(NECTIN4)

LALB:

132511511(NECTIN4)

GMF:	115844727(NECTIN4)

DDP:	132438521(NECTIN4)

SCOO:

307189128(NECTIN4)

PCRS:

137219580(NECTIN4)

DLE:	111167050(NECTIN4)

PCAD:

102995287(NECTIN4)

PSIU:

116759190(NECTIN4)

PPHC:

136122171(NECTIN4)

NASI:

112407944(NECTIN4)

HAMP:

307048653(NECTIN4)

ECB:	100066309(NECTIN4)

EPZ:	103560004(NECTIN4)

EAI:	106827591(NECTIN4)

MYB:	102244098(NECTIN4)

MYD:	102773156(NECTIN4)

MMYO:

118673345(NECTIN4)

MDT:	132220675(NECTIN4)

MYUM:

138995370(NECTIN4)

PKL:	118716900(NECTIN4)

EFUS:

103296541(NECTIN4)

POTS:

308237211(NECTIN4)

MNA:	107535089(NECTIN4)

DRO:	112322878(NECTIN4)

SHON:

118979222(NECTIN4)

AJM:	119052838(NECTIN4)

PDIC:

114489496(NECTIN4)

PHAS:

123818530(NECTIN4)

MMF:	118637326(NECTIN4)

PPAM:

129081946(NECTIN4)

HAI:	109376929(NECTIN4)

RFQ:	117014967(NECTIN4)

RHII:

308487046(NECTIN4)

PALE:

102878057(NECTIN4)

PGIG:

120584216(NECTIN4)

PVP:	105303386(NECTIN4)

RAY:	107504667(NECTIN4)

MJV:	108383517(NECTIN4)

TOD:	119241386(NECTIN4)

SARA:

101536864(PVRL4)

SFUM:

130045116(NECTIN4)

SETR:

126013853(NECTIN4)

LAV:	100670913(NECTIN4)

TMU:

101351827

ETF:	101654060(NECTIN4)

DNM:	101423651(NECTIN4)

MDO:	100032730(NECTIN4)

GAS:	123246678(NECTIN4)

SHR:	100921171(NECTIN4)

AFZ:

127562474

PCW:	110197989(NECTIN4)

TVP:	118857570(NECTIN4)

PBRV:

138147840(NECTIN4)

MLAO:

141488218(NECTIN4)

OAA:	100078419(NECTIN4)

TACU:

119946948(NECTIN4)

GGA:	101750739(nectin-4)

PCOC:

116238837(NECTIN4)

MGP:

104916297

CJO:	107324322(NECTIN4)

AACU:

137845552(NECTIN4)

BCLA:

308454083(NECTIN4)

ACYG:

125181551(NECTIN4)

ABRC:

308183721(NECTIN4)

CATA:

118260487(NECTIN4)

AFUL:

116499584(NECTIN4)

TGU:	115498388(NECTIN4)

LSR:	110479042(NECTIN4)

VMC:	128820356(NECTIN4)

VCHA:

128801214(NECTIN4)

AIB:	137463649(NECTIN4) 137467774

PMOA:

120505224(NECTIN4)

OTC:	121338555(NECTIN4)

PRUF:

121360154(NECTIN4)

ATRC:

139586989(NECTIN4)

MAEN:

136568326(NECTIN4)

FAB:	101819990(NECTIN4)

OMA:	130263407(NECTIN4)

PHI:	102107089(PVRL4)

ACOE:

138101043(NECTIN4)

ETL:	114071452(NECTIN4)

ZLE:	135457737(NECTIN4)

SVG:	106863866(PVRL4)

HRT:	120748022(NECTIN4)

CFAI:

136302952(NECTIN4)

CCIC:

134055112(NECTIN4)

SHAB:

115602530(NECTIN4)

POCC:

134174582(NECTIN4)

FPG:	101923320(NECTIN4)

FCH:	102059980(NECTIN4)

FRS:	119159216(NECTIN4)

ANOC:

141971712(NECTIN4)

SURA:

141936513(NECTIN4)

TALA:

116959010(NECTIN4)

ACHC:

115346516(NECTIN4)

HLE:	104831376(PVRL4)

AGEN:

126040936

HHAR:

128145566(NECTIN4)

BBUT:

142036917(NECTIN4)

PPUS:

135192573(NECTIN4)

NNI:	104014442(PVRL4)

AFOR:

103900541(NECTIN4)

CBOR:

142094122(NECTIN4)

CBOY:

140644122(NECTIN4)

MAME:

142420779(NECTIN4)

CLV:

102095428

CNIC:

136000188(NECTIN4)

NMAY:

308051003(NECTIN4)

CUCA:

128849425(NECTIN4)

PCUR:

138732067(NECTIN4)

GAME:

129197848(NECTIN4)

CEUR:

306730131(NECTIN4)

RTD:	128901043(NECTIN4)

CRID:

134526063(NECTIN4)

LMIC:

141734641(NECTIN4)

NARQ:

141475975(NECTIN4)

AAM:	106482204(NECTIN4)

AROW:

112974580(NECTIN4)

NPD:	112955226(NECTIN4)

SCAM:

104139747(PVRL4)

ASN:	102382986(NECTIN4)

AMJ:	102572769(NECTIN4)

PSS:	102450761(NECTIN4)

CIZ:	142003610(NECTIN4)

CMY:	102942282(NECTIN4)

CCAY:

125625554(NECTIN4)

LKP:	140902726(NECTIN4)

NDS:	141977161(NECTIN4)

DCC:	119847744(NECTIN4)

CPIC:

101941673(NECTIN4)

TST:	117869912(NECTIN4)

CABI:

116825354(NECTIN4)

MRV:	120390001(NECTIN4)

EMQ:	137167341(NECTIN4)

ASAO:

132764036(NECTIN4)

PVT:	110088128(NECTIN4)

SUND:

121915664(NECTIN4)

PBI:	103064147(NECTIN4)

PMUR:

107295515(NECTIN4)

CTIG:

120314902(NECTIN4)

TSR:	106547334(PVRL4)

PGUT:

117657691 132709287

PCAE:

139321952(NECTIN4)

APRI:

131186447(NECTIN4)

PTEX:

113446656(NECTIN4)

NSS:	113423828(NECTIN4)

VKO:	123032872(NECTIN4)

PMUA:

114586704(NECTIN4)

PRAF:

128403763(NECTIN4)

ZVI:	118075677(NECTIN4)

HCG:	128337574(NECTIN4)

GJA:	107107961(NECTIN4)

STOW:

125425248(NECTIN4)

EMC:	129343492(NECTIN4)

XLA:	108699169(nectin4.L) 108700453(nectin4.S)

XTR:	101734085(nectin4)

NPR:	108794231(NECTIN4)

RTEM:

120920228(NECTIN4)

ACAT:

141116501(NECTIN4)

PADS:

140341940(NECTIN4)

BBUF:

120982088(NECTIN4)

BGAR:

122923237(NECTIN4)

DTC:	141055629(NECTIN4)

PWL:	138268539(NECTIN4)

MUO:	115457851(NECTIN4)

GSH:	117350867(NECTIN4)

DRE:	560512(nectin4a) 794920(nectin4b)

DAES:

130231743(nectin4a)

SRX:	107710657 107726329 107731923 107750220

SANH:

107671794 107679292 107683506 107696495

SGH:	107549793 107552666 107558436 107597911

CCAR:

109060792 109063444 109065194 109093675(nectin4a)

CAUA:

113045203 113052270 113105524 113111430 113112353

CGIB:

127938436 127962535 128017269 128018156 128030266

PTET:

122348349(nectin4a) 122359744(nectin4b)

LROH:

127168458(nectin4a) 127180405(nectin4b)

GRF:	141332198(nectin4a) 141343750 141343790

OMC:	131543759(nectin4a) 131552981(nectin4b)

PPRM:

120470131(nectin4a) 120471317(nectin4b)

RKG:	130091402(nectin4a) 130103359(nectin4b)

MAMB:

125251138(nectin4b) 125265469(nectin4a)

CIDE:

127496315 127516701

CERY:

137003703(nectin4b) 137030547(nectin4a)

MASI:

127413090 127441337 127443025 127451292

TROS:

130553815(nectin4b) 130557961(nectin4a)

TDW:	130418138(nectin4b) 130427615(nectin4a)

MANU:

129438050(nectin4a) 129443246 129443251

PDAB:

135744068(nectin4b) 135764802(nectin4a)

IPU:	108267696(nectin4a) 108280452(nectin4b)

IFU:	128609935(nectin4a) 128624457(nectin4b)

PHYP:

113533133 113539945

SMEO:

124388073(nectin4a) 124403064(nectin4b)

TFD:	113645180(nectin4b) 113657453(nectin4a)

TVC:	132845676(nectin4b) 132848510(nectin4a)

CGAR:

128513047(nectin4b) 128530734(nectin4a)

NGRA:

132871766(nectin4b) 132894363(nectin4a)

TRN:	134302916(nectin4b) 134311901(nectin4a)

AMEX:

103028367(nectin4a) 103039995(nectin4b)

CMAO:

118796701(nectin4b) 118825741(nectin4a)

EEE:	113581835 113584679(nectin4)

CHAR:

116224673(nectin4a)

SPIL:

134059978(nectin4a) 134072290(nectin4b)

ASAD:

121708832(nectin4b)

TRU:	105416819(nectin4a) 105418813(nectin4b)

TFS:	130522867(nectin4a) 130539362(nectin4b)

TNG:	GSTEN00006153G001

NCC:	104945965(pvrl4)

TBEN:

117487759(nectin4a) 117500205(nectin4b)

CGOB:

115022989 115023799

PGEO:

117462697(nectin4b) 117463823(nectin4a)

GACU:

117540881(nectin4b) 117542760(nectin4a)

EMAC:

134866297(nectin4b) 134876119(nectin4a)

ELY:	117272502(nectin4b) 117272757(nectin4a)

EFO:	125883893(nectin4a) 125902050(nectin4b)

PLEP:

121951940(nectin4b) 121961862(nectin4a)

SLUC:

116042355(nectin4a) 116048831(nectin4b)

ECRA:

117934775(nectin4a) 117953688(nectin4b)

ESP:	116699402 116707058 116707440

PFLV:

114545449 114565695

GAT:	120815595(nectin4b) 120821984(nectin4a)

PPUG:

119206043(nectin4b) 119223110(nectin4a)

AFB:	129093634(nectin4a) 129111256(nectin4b)

CLUM:

117746041(nectin4b) 117748020(nectin4a)

PSWI:

130190955(nectin4b) 130211820(nectin4a)

CANA:

137782209(nectin4b) 137792358(nectin4a)

CVE:	137874953(nectin4a) 137888071(nectin4b)

MSAM:

119901765(nectin4b) 119912249(nectin4a)

SCHU:

122869792(nectin4a) 122887480(nectin4b)

EARM:

139296724(nectin4b) 139305699(nectin4a)

CUD:	121504239(nectin4a) 121520464(nectin4b)

SPUL:

138600655(nectin4a) 138611483(nectin4b)

LMIX:

132958383(nectin4a) 132979494(nectin4b)

HTC:	141784396 141803877(nectin4b)

ALAT:

119011481(nectin4b) 119026927(nectin4a)

ASTR:

137590617(nectin4a) 137611812(nectin4b)

PKLU:

139214198(nectin4b) 139222663(nectin4a)

LCO:	104924065 104936432

MZE:	101464514(nectin4b) 101466856(nectin4a)

ONL:	102077893 102081907 109194266

OAU:	116315505(nectin4a) 116326794(nectin4b)

OLA:	101169484 101174954

OML:	112150793(nectin4b) 112150988 112156091

CSAI:

133420260(nectin4a) 133452532(nectin4b)

XMA:	102221191 106699654

XCO:	114146800 114157697

XHE:	116721979 116732822

PRET:

103479517(nectin4b) 103480171

PFOR:

103138030 103140610(nectin4)

PLAI:

106947240(pvrl4) 106961175 106961181

PMEI:

106931209 106933623

GAF:	122820506(nectin4a)

PPRL:

129378082(nectin4b) 129378161(nectin4a)

CVG:	107100161 107100888

CTUL:

119772115 119772157 119779696(nectin4b)

GMU:	124870184 124880230(nectin4a)

NFU:	107372324 107372939 107383475 107384774(nectin4)

KMR:	108232912(nectin4b) 108239407(nectin4a)

ALIM:

106520761 106527933(pvrl4)

NWH:	119414685(nectin4a) 119414794(nectin4b)

LTU:	140269508(nectin4b) 140281407(nectin4a)

MCEP:

125010241(nectin4b) 125015329(nectin4a)

AOCE:

111562552(nectin4a) 111579135

EJA:	138204040(nectin4a) 138215812(nectin4b)

BFRE:

138626939(nectin4b) 138635345(nectin4a)

LCF:	108882030(nectin4a) 108884307(nectin4b)

CSEM:

103391244(nectin4) 103392118 103396736

POV:	109637593(nectin4) 109639161

SSEN:

122766393(nectin4a) 122775344(nectin4b)

SSOE:

131456088(nectin4a) 131469522(nectin4b)

HHIP:

117778841(nectin4b) 117779269(nectin4a)

HSP:	118102483(nectin4a) 118117523(nectin4b)

PPLT:

128430450(nectin4a) 128454262 128454263 128454265

SMAU:

118300819(nectin4a) 118310684(nectin4b)

SDU:	111226943 111231142

SLAL:

111646967(nectin4) 111668389

XGL:	120797128(nectin4a) 120798651(nectin4b)

HCQ:	109511892 109524095

SSCV:

125985517 125985531(nectin4b)

SBIA:

133494861(nectin4a) 133510709(nectin4b)

PEE:	133397717(nectin4a) 133411210(nectin4b)

PTAO:

133472925(nectin4a) 133488771(nectin4b)

BPEC:

110157816 110171243

ENY:	140355575(nectin4b) 140371388(nectin4a)

MALB:

109951566 109969415

BSPL:

114844619 114866829(nectin4a)

SJO:	128368719(nectin4b) 128384376(nectin4a)

SSCO:

133990018(nectin4b) 134005587(nectin4a)

TTY:	137174915(nectin4a) 137194550(nectin4b)

GMH:	115529993 115548734

SASA:

106569380 106577661 106600388 106608750

STRU:

115157282(nectin4b) 115169513 115194302 115198310

OTW:	112214688(nectin4a) 112226732 112259940 112260728

OMY:	110500562(nectin4a) 110508505 110530562 110531693

OGO:	124007711 124009222 124013609(nectin4a) 124041614

ONE:	115102801 115114646 115133510 115138041

OKI:	109871961 109875048 109879301 109906246

OKE:	118368805 118392020 118394950 118401908

OMM:	135510568 135511772 135559011

OCLA:

139376225 139378957 139386996 139416071

SALP:

111953720 111956640 111960169 111979298

SNH:	120020638 120030242 120049675 120056063

SFON:

129813829 129824223 129835292 129865683

CCLU:

121535609 121554465 121572988 121581105

ELS:	105021867 105030959

OEP:	134009886(nectin4a) 134036041(nectin4b)

SFM:	108925957(nectin4) 108937944

PKI:	111833147 111845369(nectin4)

AANG:

118232652 118234017

AROT:

135258669 135260634

CCOG:

133120031 133136970

LOC:	102686714(pvrl4)

PSPA:

121302382 121307244

ARUT:

117410086 117968547

LCM:	102352699(NECTIN4)

CPUN:

140468487

HOC:

132813239

SCAU:

119967790

LERI:

129708720(nectin4a)

HAKA:

140717412

BFO:	118429931 118429935

BBEL:

109479636 109480159 109480186

PCAN:

112568349

CVN:

111101367

» show all

Reference

PMID:15561584

Authors

Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.

Title

Roles and modes of action of nectins in cell-cell adhesion.

Journal

Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002

Sequence

[hsa:81607]

Reference

PMID:12901789

Authors

Takai Y, Irie K, Shimizu K, Sakisaka T, Ikeda W.

Title

Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization.

Journal

Cancer Sci 94:655-67 (2003)
DOI:10.1111/j.1349-7006.2003.tb01499.x

LinkDB

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