KEGG   PATHWAY: csab04727
Entry
csab04727                   Pathway                                
Name
GABAergic synapse - Chlorocebus sabaeus (green monkey)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
csab04727  GABAergic synapse
csab04727

Other DBs
GO: 0051932
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103238195  SLC38A1; solute carrier family 38 member 1 [KO:K14990]
103238196  SLC38A2; solute carrier family 38 member 2 [KO:K14207]
103217527  GLS; glutaminase [KO:K01425] [EC:3.5.1.2]
103238531  GLS2; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
103238027  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
103217294  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
103246166  SLC32A1; solute carrier family 32 member 1 [KO:K15015]
103227954  ABAT; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.19 2.6.1.22]
103232759  GABRA3; gamma-aminobutyric acid type A receptor alpha3 subunit [KO:K05175]
103244913  GABRA1; gamma-aminobutyric acid type A receptor alpha1 subunit [KO:K05175]
103244915  GABRA6; gamma-aminobutyric acid type A receptor alpha6 subunit [KO:K05175]
103246006  GABRA5; gamma-aminobutyric acid type A receptor alpha5 subunit [KO:K05175]
103246143  GABRA4; gamma-aminobutyric acid type A receptor alpha4 subunit [KO:K05175]
103246148  GABRA2; gamma-aminobutyric acid type A receptor alpha2 subunit [KO:K05175]
103246008  GABRB3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
103244912  GABRB2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
103246145  GABRB1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
103244917  GABRG2; gamma-aminobutyric acid type A receptor gamma2 subunit [KO:K05186]
103246004  GABRG3; gamma-aminobutyric acid type A receptor gamma3 subunit [KO:K05186]
103246149  GABRG1; gamma-aminobutyric acid type A receptor gamma1 subunit [KO:K05186]
103225775  GABRD; gamma-aminobutyric acid type A receptor delta subunit [KO:K05184]
103232754  GABRE; gamma-aminobutyric acid type A receptor epsilon subunit [KO:K05185]
103232761  GABRQ; gamma-aminobutyric acid type A receptor theta subunit [KO:K05192]
103244961  GABRP; gamma-aminobutyric acid type A receptor pi subunit [KO:K05189]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103234377  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103235232  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103243441  HAP1; huntingtin associated protein 1 [KO:K04647]
103231198  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
103233317  GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
103242281  GABARAP; GABA type A receptor-associated protein [KO:K08341]
103218578  GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
103243257  NSF; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027] [EC:3.6.4.6]
103217643  TRAK2; trafficking kinesin protein 2 [KO:K15374]
103217592  PLCL1; phospholipase C like 1 [KO:K15375]
103229192  GPHN; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
103245072  SLC12A5; solute carrier family 12 member 5 [KO:K23967]
103228486  GABRR3; gamma-aminobutyric acid type A receptor rho3 subunit [KO:K05190]
103240098  GABRR1; gamma-aminobutyric acid type A receptor rho1 subunit [KO:K05190]
103240100  GABRR2; gamma-aminobutyric acid type A receptor rho2 subunit [KO:K05190]
103234371  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103239541  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103218385  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103227762  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103231971  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103230339  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103219146  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
103221881  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
103227664  GNAI2; G protein subunit alpha i2 [KO:K04630]
103224284  GNAI3; G protein subunit alpha i3 [KO:K04630]
103226652  GNAI1; G protein subunit alpha i1 [KO:K04630]
103233012  GNAO1; G protein subunit alpha o1 [KO:K04534]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103226542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103226115  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
103214981  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
103220665  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
103228726  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
103228169  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103238242  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
103232667  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
103237447  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
103227576  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
103218752  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
103228010  SLC6A1; solute carrier family 6 member 1 [KO:K05034]
103218350  SLC6A13; solute carrier family 6 member 13 [KO:K05046]
103228009  SLC6A11; solute carrier family 6 member 11 [KO:K05044]
103218348  SLC6A12; solute carrier family 6 member 12 [KO:K05045]
103230475  GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
103227662  SLC38A3; solute carrier family 38 member 3 [KO:K13576]
103232923  SLC38A5; solute carrier family 38 member 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
csab00020  Citrate cycle (TCA cycle)
csab00250  Alanine, aspartate and glutamate metabolism
csab04144  Endocytosis
csab04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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