KEGG   PATHWAY: csat03410
Entry
csat03410                   Pathway                                
Name
Base excision repair - Camelina sativa (false flax)
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
csat03410  Base excision repair
csat03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Camelina sativa (false flax) [GN:csat]
Gene
104756510  N-glycosylase/DNA lyase OGG1 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
104740866  N-glycosylase/DNA lyase OGG1-like [KO:K03660] [EC:3.2.2.- 4.2.99.18]
104776290  N-glycosylase/DNA lyase OGG1 isoform X1 [KO:K03660] [EC:3.2.2.- 4.2.99.18]
104786473  endonuclease III homolog 1, chloroplastic-like isoform X1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104790990  putative DNA glycosylase At3g47830 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104754746  endonuclease III homolog 2, chloroplastic-like isoform X1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104763823  endonuclease III homolog 2, chloroplastic-like [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104749728  endonuclease III homolog 1, chloroplastic-like isoform X1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104739140  endonuclease III homolog 2, chloroplastic-like [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104780590  putative DNA glycosylase At3g47830 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104700321  endonuclease III homolog 1, chloroplastic-like isoform X1 [KO:K10773] [EC:3.2.2.- 4.2.99.18]
104769618  uncharacterized protein LOC104769618 [KO:K10569] [EC:3.2.2.- 4.2.99.18]
104735405  uncharacterized protein LOC104735405 [KO:K10569] [EC:3.2.2.- 4.2.99.18]
104705655  uncharacterized protein LOC104705655 [KO:K10569] [EC:3.2.2.- 4.2.99.18]
104765724  uracil-DNA glycosylase, mitochondrial [KO:K03648] [EC:3.2.2.27]
104783607  uracil-DNA glycosylase, mitochondrial-like [KO:K03648] [EC:3.2.2.27]
104746238  uracil-DNA glycosylase, mitochondrial-like [KO:K03648] [EC:3.2.2.27]
109127979  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104728097  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104728098  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104733726  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104719186  adenine DNA glycosylase-like isoform X1 [KO:K03575] [EC:3.2.2.31]
109132411  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104773440  adenine DNA glycosylase-like [KO:K03575] [EC:3.2.2.31]
104745418  DNA-3-methyladenine glycosylase-like [KO:K03652] [EC:3.2.2.21]
104764965  DNA-3-methyladenine glycosylase-like [KO:K03652] [EC:3.2.2.21]
104776133  DNA-3-methyladenine glycosylase [KO:K03652] [EC:3.2.2.21]
104740855  methyl-CpG-binding domain protein 4-like protein isoform X1 [KO:K10801] [EC:3.2.2.-]
104744987  methyl-CpG-binding domain protein 4-like protein isoform X1 [KO:K10801] [EC:3.2.2.-]
104764520  methyl-CpG-binding domain protein 4-like protein [KO:K10801] [EC:3.2.2.-]
104765305  polynucleotide 3'-phosphatase ZDP-like [KO:K08073] [EC:3.1.3.32 2.7.1.78]
104745771  polynucleotide 3'-phosphatase ZDP-like isoform X1 [KO:K08073] [EC:3.1.3.32 2.7.1.78]
104779599  polynucleotide 3'-phosphatase ZDP isoform X2 [KO:K08073] [EC:3.1.3.32 2.7.1.78]
104705792  tyrosyl-DNA phosphodiesterase 1-like isoform X1 [KO:K10862] [EC:3.1.4.-]
104769757  tyrosyl-DNA phosphodiesterase 1 isoform X1 [KO:K10862] [EC:3.1.4.-]
104768943  DNA polymerase beta-like [KO:K03512] [EC:2.7.7.7 4.2.99.-]
104739664  DNA polymerase beta-like [KO:K03512] [EC:2.7.7.7 4.2.99.-]
104755267  DNA polymerase beta-like [KO:K03512] [EC:2.7.7.7 4.2.99.-]
104749712  poly [ADP-ribose] polymerase 1-like [KO:K24070] [EC:2.4.2.30]
104786487  poly [ADP-ribose] polymerase 1-like [KO:K24070] [EC:2.4.2.30]
104700335  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
104770581  poly [ADP-ribose] polymerase 3 [KO:K10798] [EC:2.4.2.30]
104733976  poly [ADP-ribose] polymerase 2-like [KO:K10798] [EC:2.4.2.30]
104706536  poly [ADP-ribose] polymerase 3-like [KO:K10798] [EC:2.4.2.30]
104707861  poly [ADP-ribose] polymerase 2-like isoform X1 [KO:K10798] [EC:2.4.2.30]
104736255  poly [ADP-ribose] polymerase 3-like [KO:K10798] [EC:2.4.2.30]
104737539  poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
104724348  poly [ADP-ribose] polymerase 2-like [KO:K10798] [EC:2.4.2.30]
104714036  poly [ADP-ribose] polymerase 2-like isoform X1 [KO:K10798] [EC:2.4.2.30]
104786429  poly(ADP-ribose) glycohydrolase 1 isoform X1 [KO:K07759] [EC:3.2.1.143]
104786426  poly(ADP-ribose) glycohydrolase 1-like [KO:K07759] [EC:3.2.1.143]
104786428  probable poly(ADP-ribose) glycohydrolase 2 isoform X1 [KO:K07759] [EC:3.2.1.143]
104749683  probable poly(ADP-ribose) glycohydrolase 2 isoform X1 [KO:K07759] [EC:3.2.1.143]
104749684  poly(ADP-ribose) glycohydrolase 1 isoform X1 [KO:K07759] [EC:3.2.1.143]
104749685  poly(ADP-ribose) glycohydrolase 1-like [KO:K07759] [EC:3.2.1.143]
104700279  probable poly(ADP-ribose) glycohydrolase 2 [KO:K07759] [EC:3.2.1.143]
104700280  poly(ADP-ribose) glycohydrolase 1-like isoform X1 [KO:K07759] [EC:3.2.1.143]
104734171  transcription factor bHLH140-like isoform X1 [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
104708982  transcription factor bHLH140-like isoform X2 [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
104768332  transcription factor bHLH140 isoform X1 [KO:K10863] [EC:3.6.1.70 3.6.1.71 3.6.1.72]
104714337  DNA-repair protein XRCC1-like [KO:K10803]
104705100  DNA-repair protein XRCC1-like [KO:K10803]
104752481  DNA-repair protein XRCC1-like isoform X2 [KO:K10803]
104762542  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
104763660  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
104741965  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
104727025  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
104785163  DNA polymerase delta small subunit isoform X1 [KO:K02328]
104782708  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
104793129  DNA polymerase delta small subunit-like isoform X1 [KO:K02328]
104703199  uncharacterized protein LOC104703199 isoform X1 [KO:K03504]
104714133  uncharacterized protein LOC104714133 isoform X1 [KO:K03504]
104752293  chromatin modification-related protein EAF7-like isoform X2 [KO:K03504]
104755187  uncharacterized protein LOC104755187 [KO:K03505]
104739581  uncharacterized protein LOC104739581 [KO:K03505]
104768141  uncharacterized protein LOC104768141 [KO:K03505]
104755005  LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
104778622  DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
104773941  DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
104727767  DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]
104733317  DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
104767000  DNA polymerase epsilon subunit B-like isoform X1 [KO:K02325] [EC:2.7.7.7]
104706503  DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
104704311  DNA polymerase epsilon subunit B-like [KO:K02325] [EC:2.7.7.7]
104770531  DNA polymerase epsilon subunit B-like isoform X1 [KO:K02325] [EC:2.7.7.7]
104736223  DNA polymerase epsilon subunit B [KO:K02325] [EC:2.7.7.7]
104786982  putative DNA helicase INO80 [KO:K02326] [EC:2.7.7.7]
104703556  DNA polymerase epsilon subunit 3-like isoform X1 [KO:K02326] [EC:2.7.7.7]
104752634  uncharacterized protein DDB_G0290685 isoform X1 [KO:K02326] [EC:2.7.7.7]
104739381  uncharacterized protein LOC104739381 [KO:K03506] [EC:2.7.7.7]
109124439  proliferating cellular nuclear antigen 1 [KO:K04802]
104754904  proliferating cellular nuclear antigen 1 [KO:K04802]
104765400  proliferating cellular nuclear antigen 1 [KO:K04802]
104789216  proliferating cell nuclear antigen 2-like [KO:K04802]
104749924  proliferating cell nuclear antigen 2-like [KO:K04802]
104786729  proliferating cell nuclear antigen 2 [KO:K04802]
104700546  proliferating cell nuclear antigen 2 [KO:K04802]
104704389  proliferating cell nuclear antigen 2-like [KO:K04802]
104770522  replication factor C subunit 1 [KO:K10754]
104736212  replication factor C subunit 1 [KO:K10754]
104706490  replication factor C subunit 1 [KO:K10754]
104776287  replication factor C subunit 4 [KO:K10755]
104743444  replication factor C subunit 4-like [KO:K10755]
104756506  replication factor C subunit 4 [KO:K10755]
104703935  replication factor C subunit 2 [KO:K10755]
104714668  replication factor C subunit 2 [KO:K10755]
104752983  replication factor C subunit 2 [KO:K10755]
104771187  replication factor C subunit 3 [KO:K10756]
104751642  replication factor C subunit 5-like [KO:K10756]
104707025  replication factor C subunit 3 [KO:K10756]
104713414  replication factor C subunit 5-like [KO:K10756]
104736737  replication factor C subunit 3 [KO:K10756]
104702530  replication factor C subunit 5 [KO:K10756]
104771140  flap endonuclease 1-like isoform X2 [KO:K04799] [EC:3.1.-.-]
104736684  flap endonuclease 1 isoform X1 [KO:K04799] [EC:3.1.-.-]
104706974  flap endonuclease 1-like isoform X2 [KO:K04799] [EC:3.1.-.-]
104754994  DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
104739397  DNA ligase 1-like [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
104759983  formamidopyrimidine-DNA glycosylase-like [KO:K10563] [EC:3.2.2.23 4.2.99.18]
104742751  formamidopyrimidine-DNA glycosylase-like isoform X1 [KO:K10563] [EC:3.2.2.23 4.2.99.18]
104778169  formamidopyrimidine-DNA glycosylase isoform X1 [KO:K10563] [EC:3.2.2.23 4.2.99.18]
104776063  DNA-3-methyladenine glycosylase-like [KO:K01247] [EC:3.2.2.21]
104713169  probable DNA-3-methyladenine glycosylase 2 isoform X1 [KO:K01247] [EC:3.2.2.21]
104702259  uncharacterized protein LOC104702259 isoform X2 [KO:K01247] [EC:3.2.2.21]
104756292  DNA-3-methyladenine glycosylase-like [KO:K01247] [EC:3.2.2.21]
104740644  uncharacterized protein LOC104740644 [KO:K01247] [EC:3.2.2.21]
104780915  DNA-3-methyladenine glycosylase 1-like [KO:K01247] [EC:3.2.2.21]
104791315  DNA-3-methyladenine glycosylase 1-like [KO:K01247] [EC:3.2.2.21]
104710055  DNA-3-methyladenine glycosylase 1-like [KO:K01247] [EC:3.2.2.21]
104751394  DNA-3-methyladenine glycosylase-like isoform X1 [KO:K01247] [EC:3.2.2.21]
104765039  uncharacterized protein LOC104765039 [KO:K01246] [EC:3.2.2.20]
104760495  uncharacterized protein LOC104760495 [KO:K01246] [EC:3.2.2.20]
104761888  uncharacterized protein LOC104761888 isoform X1 [KO:K01246] [EC:3.2.2.20]
104772561  uncharacterized protein LOC104772561 [KO:K01246] [EC:3.2.2.20]
104702246  uncharacterized protein LOC104702246 [KO:K01246] [EC:3.2.2.20]
104745492  uncharacterized protein LOC104745492 [KO:K01246] [EC:3.2.2.20]
104752430  LOW QUALITY PROTEIN: uncharacterized protein LOC104752430 [KO:K01246] [EC:3.2.2.20]
104771648  uncharacterized protein LOC104771648 [KO:K01246] [EC:3.2.2.20]
104776915  uncharacterized protein LOC104776915 [KO:K01246] [EC:3.2.2.20]
104740283  uncharacterized protein LOC104740283 [KO:K01246] [EC:3.2.2.20]
104703348  uncharacterized protein LOC104703348 isoform X2 [KO:K01246] [EC:3.2.2.20]
104735009  uncharacterized protein LOC104735009 [KO:K01246] [EC:3.2.2.20]
104740019  uncharacterized protein LOC104740019 [KO:K01246] [EC:3.2.2.20]
104726362  uncharacterized protein LOC104726362 [KO:K01246] [EC:3.2.2.20]
104724961  uncharacterized protein LOC104724961 [KO:K01246] [EC:3.2.2.20]
104713152  uncharacterized protein LOC104713152 [KO:K01246] [EC:3.2.2.20]
104714283  uncharacterized protein LOC104714283 [KO:K01246] [EC:3.2.2.20]
104774814  uncharacterized protein LOC104774814 [KO:K01246] [EC:3.2.2.20]
104755913  uncharacterized protein LOC104755913 [KO:K01246] [EC:3.2.2.20]
104755649  uncharacterized protein LOC104755649 [KO:K01246] [EC:3.2.2.20]
104751380  uncharacterized protein LOC104751380 isoform X1 [KO:K01246] [EC:3.2.2.20]
104793056  DNA-(apurinic or apyrimidinic site) lyase, chloroplastic isoform X1 [KO:K01142] [EC:3.1.11.2]
104785237  DNA-(apurinic or apyrimidinic site) lyase, chloroplastic-like [KO:K01142] [EC:3.1.11.2]
104782633  DNA-(apurinic or apyrimidinic site) lyase, chloroplastic [KO:K01142] [EC:3.1.11.2]
104758386  DNA polymerase I A, chloroplastic/mitochondrial isoform X4 [KO:K02335] [EC:2.7.7.7]
109124566  DNA polymerase I B, chloroplastic/mitochondrial-like isoform X1 [KO:K02335] [EC:2.7.7.7]
104742609  DNA polymerase I A, chloroplastic/mitochondrial [KO:K02335] [EC:2.7.7.7]
104746465  DNA polymerase I B, chloroplastic/mitochondrial isoform X1 [KO:K02335] [EC:2.7.7.7]
104785519  DNA polymerase I B, chloroplastic/mitochondrial isoform X1 [KO:K02335] [EC:2.7.7.7]
Reference
PMID:17893748
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
PMID:17337257
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
PMID:21665970
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
PMID:11436317
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
LinkDB

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