KEGG   PATHWAY: cvg00260
Entry
cvg00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cyprinodon variegatus (sheepshead minnow)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cvg00260  Glycine, serine and threonine metabolism
cvg00260

Module
cvg_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cvg00260]
cvg_M00047  Creatine pathway [PATH:cvg00260]
cvg_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cvg00260]
cvg_M00555  Betaine biosynthesis, choline => betaine [PATH:cvg00260]
cvg_M00621  Glycine cleavage system [PATH:cvg00260]
cvg_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cvg00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107089199  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
107086694  serine hydroxymethyltransferase, mitochondrial-like isoform X1 [KO:K00600] [EC:2.1.2.1]
107103250  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
107104201  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
107104202  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
107104203  serine hydroxymethyltransferase, cytosolic-like isoform X1 [KO:K00600] [EC:2.1.2.1]
107082426  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107083359  agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107085712  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
107088233  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
107089335  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
107090948  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
107100573  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
107082437  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
107095033  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
107093541  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107085296  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
107088323  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
107094633  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
107096419  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
107082743  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
107102832  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
107087501  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
107102244  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
107104513  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
107102239  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
107085199  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107098941  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107083227  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
107090538  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
107090188  gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
107091246  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
107085798  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107085365  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
107096976  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
107086681  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
107103171  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107093785  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
107092484  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
107092421  betaine--homocysteine S-methyltransferase 1-like isoform X1 [KO:K00544] [EC:2.1.1.5]
107093770  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
107093112  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107088710  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
107084845  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
107104501  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107098785  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107104210  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
107087556  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
107086831  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107101557  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107097021  D-threo-3-hydroxyaspartate dehydratase-like [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cvg00010  Glycolysis / Gluconeogenesis
cvg00020  Citrate cycle (TCA cycle)
cvg00230  Purine metabolism
cvg00250  Alanine, aspartate and glutamate metabolism
cvg00270  Cysteine and methionine metabolism
cvg00290  Valine, leucine and isoleucine biosynthesis
cvg00330  Arginine and proline metabolism
cvg00470  D-Amino acid metabolism
cvg00564  Glycerophospholipid metabolism
cvg00600  Sphingolipid metabolism
cvg00620  Pyruvate metabolism
cvg00630  Glyoxylate and dicarboxylate metabolism
cvg00640  Propanoate metabolism
cvg00860  Porphyrin metabolism
cvg00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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