KEGG   PATHWAY: cvg04146
Entry
cvg04146                    Pathway                                
Name
Peroxisome - Cyprinodon variegatus (sheepshead minnow)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
cvg04146  Peroxisome
cvg04146

Other DBs
GO: 0005777
Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107098857  pex16; peroxisomal biogenesis factor 16 [KO:K13335]
107103998  pex3; peroxisomal biogenesis factor 3 [KO:K13336]
107100877  pex19; peroxisomal biogenesis factor 19 [KO:K13337]
107080916  uncharacterized protein LOC107080916 [KO:K05677] [EC:7.6.2.4]
107083293  pex1; peroxisome biogenesis factor 1 isoform X1 [KO:K13338]
107088643  pex6; LOW QUALITY PROTEIN: peroxisome biogenesis factor 6 [KO:K13339]
107095912  pex26; peroxisome assembly protein 26 [KO:K13340]
107080807  peroxisomal targeting signal 2 receptor-like [KO:K13341]
107081009  peroxisomal targeting signal 2 receptor-like isoform X1 [KO:K13341]
107100351  PEX5-related protein-like [KO:K13342]
107082249  pex5; peroxisomal biogenesis factor 5 isoform X1 [KO:K13342]
107096035  PEX5-related protein-like isoform X1 [KO:K13342]
107086897  pex14; peroxisomal membrane protein PEX14 [KO:K13343]
107081740  pex13; peroxisome biogenesis factor 13 [KO:K13344]
107097743  pex12; peroxisome assembly protein 12 [KO:K13345]
107097450  pex10; peroxisome biogenesis factor 10 [KO:K13346]
107093932  pex2; peroxisome biogenesis factor 2 isoform X1 [KO:K06664]
107097257  pxmp2; peroxisomal membrane protein 2 [KO:K13347]
107083514  mpv17; protein Mpv17 [KO:K13348]
107088253  mpv17l2; mpv17-like protein 2 [KO:K13348]
107096614  mpv17l; mpv17-like protein [KO:K13349]
107088803  rpl18; 60S ribosomal protein L18 isoform X1 [KO:K13349]
107087695  mpv17-like protein [KO:K13349]
107103453  pxmp4; peroxisomal membrane protein 4 [KO:K13350]
107100585  peroxisomal membrane protein 11A-like [KO:K13351]
107087964  pex11b; peroxisomal membrane protein 11B [KO:K13352]
107096977  pex11g; peroxisomal membrane protein 11C [KO:K13353]
107093522  peroxisomal membrane protein PMP34-like [KO:K13354]
107092520  peroxisomal membrane protein PMP34-like [KO:K13354]
107103875  hacl1; 2-hydroxyacyl-CoA lyase 1 [KO:K12261] [EC:4.1.2.63]
107088954  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
107085808  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
107096226  phyh; phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
107104334  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
107100572  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
107086311  hsd17b4; peroxisomal multifunctional enzyme type 2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
107083609  scp2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
107083302  acyl-coenzyme A thioesterase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
107087127  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
107094433  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
107084994  decr2; peroxisomal 2,4-dienoyl-CoA reductase isoform X1 [KO:K13237] [EC:1.3.1.124]
107092492  ech1; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1 [KO:K12663] [EC:5.3.3.21]
107099844  ATP-binding cassette sub-family D member 1-like [KO:K05675] [EC:7.6.2.4]
107099036  ATP-binding cassette sub-family D member 2-like [KO:K05676] [EC:7.6.2.4]
107083652  abcd4; ATP-binding cassette sub-family D member 4 isoform X1 [KO:K05678] [EC:7.6.2.8]
107085330  slc27a2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107085357  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107087410  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
107093877  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
107089734  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
107093006  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
107087285  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
107091132  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
107094155  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
107104142  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
107104927  acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
107086832  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
107103350  eci2; enoyl-CoA delta isomerase 2, mitochondrial [KO:K13239] [EC:5.3.3.8]
107103851  nudt7; peroxisomal coenzyme A diphosphatase NUDT7 isoform X1 [KO:K17879] [EC:3.6.1.77]
107084628  nudt12; peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]
107100493  nudt13; nucleoside diphosphate-linked moiety X motif 13 [KO:K03426] [EC:3.6.1.22]
107086929  nudt19; nucleoside diphosphate-linked moiety X motif 19 [KO:K13355] [EC:3.6.1.77]
107093191  acot8; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
107086174  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
107099579  carnitine O-acetyltransferase-like [KO:K00624] [EC:2.3.1.7]
107098859  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
107096303  crot; peroxisomal carnitine O-octanoyltransferase [KO:K05940] [EC:2.3.1.137]
107084287  mlycd; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
107082867  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
107082868  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
107082051  agps; alkyldihydroxyacetonephosphate synthase, peroxisomal [KO:K00803] [EC:2.5.1.26]
107098029  far2; fatty acyl-CoA reductase 2 isoform X1 [KO:K13356] [EC:1.2.1.84]
107097250  mvk; mevalonate kinase [KO:K00869] [EC:2.7.1.36]
107095271  pmvk; phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
107082426  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107083359  agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107091246  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
107091598  ddo; D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
107087967  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
107100590  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
107104998  idh1; isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
107086571  paox; peroxisomal N(1)-acetyl-spermine/spermidine oxidase [KO:K00308] [EC:1.5.3.13]
107086572  peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like [KO:K00308] [EC:1.5.3.13]
107093112  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107098947  hmgcl; hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
107084588  hmgcll1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic [KO:K01640] [EC:4.1.3.4]
107100327  hao1; hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
107097767  hao2; hydroxyacid oxidase 2 isoform X1 [KO:K11517] [EC:1.1.3.15]
107093610  cat; catalase [KO:K03781] [EC:1.11.1.6]
107082563  prdx5; peroxiredoxin-5, mitochondrial [KO:K11187] [EC:1.11.1.24]
107087929  sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
107081429  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
107083617  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
107096609  prdx2; peroxiredoxin-2 [KO:K13279] [EC:1.11.1.24]
107096825  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
107082175  gstk1; glutathione S-transferase kappa 1 isoform X1 [KO:K13299] [EC:2.5.1.18]
107104320  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107102491  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
cvg00071  Fatty acid degradation
cvg00120  Primary bile acid biosynthesis
cvg00230  Purine metabolism
cvg00564  Glycerophospholipid metabolism
cvg00565  Ether lipid metabolism
cvg00830  Retinol metabolism
cvg00900  Terpenoid backbone biosynthesis
cvg03320  PPAR signaling pathway
KO pathway
ko04146   
LinkDB

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