KEGG   PATHWAY: cvn00600
Entry
cvn00600                    Pathway                                
Name
Sphingolipid metabolism - Crassostrea virginica (eastern oyster)
Class
Metabolism; Lipid metabolism
Pathway map
cvn00600  Sphingolipid metabolism
cvn00600

Module
cvn_M00094  Ceramide biosynthesis [PATH:cvn00600]
cvn_M00099  Sphingosine biosynthesis [PATH:cvn00600]
cvn_M00100  Sphingosine degradation [PATH:cvn00600]
Other DBs
GO: 0006665
Organism
Crassostrea virginica (eastern oyster) [GN:cvn]
Gene
111120597  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
111103667  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
111130121  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
111130191  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
111134961  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
111114186  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
111111442  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
111114931  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
111121929  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
111122385  neutral ceramidase-like [KO:K12349] [EC:3.5.1.23]
111137275  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
111127974  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
111132893  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
111124357  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
111132237  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
111135040  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
111135321  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase 4-like [KO:K12353] [EC:3.1.4.12]
111108630  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111133381  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
111129356  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
111121919  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
111137368  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
111116763  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111119138  LOW QUALITY PROTEIN: phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111129252  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
111129253  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
111129840  sphingosine-1-phosphate phosphatase 2-like [KO:K04716] [EC:3.1.3.-]
111111654  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
111111935  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
111125476  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
111125840  ceramide phosphoethanolamine synthase-like [KO:K26283] [EC:2.7.8.48]
111118144  LOW QUALITY PROTEIN: sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
111121731  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
111121732  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
111124154  sphingosine-1-phosphate lyase-like [KO:K01634] [EC:4.1.2.27]
111130733  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
111131692  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
111135173  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
111128507  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111129123  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
111129077  LOW QUALITY PROTEIN: non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
111113388  LOW QUALITY PROTEIN: beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
111133742  galactocerebrosidase-like isoform X1 [KO:K01202] [EC:3.2.1.46]
111111566  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
111112101  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
111128947  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
111131382  LOW QUALITY PROTEIN: beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111131384  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
111133398  uncharacterized protein LOC111133398 isoform X1 [KO:K12373] [EC:3.2.1.52]
111133444  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
111133929  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
111127514  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
111123646  LOW QUALITY PROTEIN: ganglioside GM2 activator-like [KO:K12383]
111125083  ganglioside GM2 activator-like [KO:K12383]
111128341  uncharacterized protein LOC111128341 [KO:K12383]
111102760  LOW QUALITY PROTEIN: ganglioside GM2 activator-like [KO:K12383]
111121876  prosaposin-like [KO:K12382]
111122386  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cvn00260  Glycine, serine and threonine metabolism
cvn00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cvn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cvn00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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