KEGG   PATHWAY: efus03040
Entry
efus03040                   Pathway                                
Name
Spliceosome - Eptesicus fuscus (big brown bat)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
efus03040  Spliceosome
efus03040

Other DBs
GO: 0005681
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
129147182  U1 spliceosomal RNA [KO:K14276]
114229920  U1 spliceosomal RNA [KO:K14276]
114234763  U1 spliceosomal RNA [KO:K14276]
114229619  U1 spliceosomal RNA [KO:K14276]
129150293  U1 spliceosomal RNA [KO:K14276]
114227920  U1 spliceosomal RNA [KO:K14276]
114232454  U1 spliceosomal RNA [KO:K14276]
114228831  U1 spliceosomal RNA [KO:K14276]
114228596  U1 spliceosomal RNA [KO:K14276]
129149597  U1 spliceosomal RNA [KO:K14276]
114229044  U1 spliceosomal RNA [KO:K14276]
114231968  U1 spliceosomal RNA [KO:K14276]
114234183  U1 spliceosomal RNA [KO:K14276]
114230504  U1 spliceosomal RNA [KO:K14276]
129147836  U1 spliceosomal RNA [KO:K14276]
129150410  U1 spliceosomal RNA [KO:K14276]
129150412  U1 spliceosomal RNA [KO:K14276]
114228587  U1 spliceosomal RNA [KO:K14276]
114234588  U1 spliceosomal RNA [KO:K14276]
114234714  U1 spliceosomal RNA [KO:K14276]
114230503  U1 spliceosomal RNA [KO:K14276]
129148894  U1 spliceosomal RNA [KO:K14276]
114233160  U1 spliceosomal RNA [KO:K14276]
114231141  U1 spliceosomal RNA [KO:K14276]
114230505  U1 spliceosomal RNA [KO:K14276]
129150422  U2 spliceosomal RNA [KO:K14277]
114227186  U2 spliceosomal RNA [KO:K14277]
114230001  U2 spliceosomal RNA [KO:K14277]
114232794  U2 spliceosomal RNA [KO:K14277]
114229343  U2 spliceosomal RNA [KO:K14277]
114229171  U2 spliceosomal RNA [KO:K14277]
114233666  U2 spliceosomal RNA [KO:K14277]
114234922  U2 spliceosomal RNA [KO:K14277]
114227766  U2 spliceosomal RNA [KO:K14277]
129147508  U2 spliceosomal RNA [KO:K14277]
129149219  U2 spliceosomal RNA [KO:K14277]
114230355  U2 spliceosomal RNA [KO:K14277]
114232705  U2 spliceosomal RNA [KO:K14277]
114232136  U4 spliceosomal RNA [KO:K14278]
114230964  U4 spliceosomal RNA [KO:K14278]
114231976  U4 spliceosomal RNA [KO:K14278]
114230513  U4 spliceosomal RNA [KO:K14278]
114231638  U4 spliceosomal RNA [KO:K14278]
114229379  U4 spliceosomal RNA [KO:K14278]
114233143  U5 spliceosomal RNA [KO:K14279]
114235063  U5 spliceosomal RNA [KO:K14279]
114235253  U5 spliceosomal RNA [KO:K14279]
114235062  U5 spliceosomal RNA [KO:K14279]
114232141  U6 spliceosomal RNA [KO:K14280]
114231447  U6 spliceosomal RNA [KO:K14280]
114227255  U6 spliceosomal RNA [KO:K14280]
114231739  U6 spliceosomal RNA [KO:K14280]
129149928  U6 spliceosomal RNA [KO:K14280]
114230515  U6 spliceosomal RNA [KO:K14280]
114228514  U6 spliceosomal RNA [KO:K14280]
114230043  U6 spliceosomal RNA [KO:K14280]
114234077  U6 spliceosomal RNA [KO:K14280]
114234076  U6 spliceosomal RNA [KO:K14280]
114227683  U6 spliceosomal RNA [KO:K14280]
129151545  U6 spliceosomal RNA [KO:K14280]
114232139  U6 spliceosomal RNA [KO:K14280]
114228839  U6 spliceosomal RNA [KO:K14280]
114230682  U6 spliceosomal RNA [KO:K14280]
114235010  U6 spliceosomal RNA [KO:K14280]
114228032  U6 spliceosomal RNA [KO:K14280]
114233424  U6 spliceosomal RNA [KO:K14280]
114232047  U6 spliceosomal RNA [KO:K14280]
114227481  U6 spliceosomal RNA [KO:K14280]
114229425  U6 spliceosomal RNA [KO:K14280]
114231291  U6 spliceosomal RNA [KO:K14280]
114230187  U6 spliceosomal RNA [KO:K14280]
129150827  U6 spliceosomal RNA [KO:K14280]
114227837  U6 spliceosomal RNA [KO:K14280]
114229199  U6 spliceosomal RNA [KO:K14280]
114227771  U6 spliceosomal RNA [KO:K14280]
114232991  U6 spliceosomal RNA [KO:K14280]
114228388  U6 spliceosomal RNA [KO:K14280]
114233789  U6 spliceosomal RNA [KO:K14280]
114235018  U6 spliceosomal RNA [KO:K14280]
114231617  U6 spliceosomal RNA [KO:K14280]
114234424  U6 spliceosomal RNA [KO:K14280]
114229808  U6 spliceosomal RNA [KO:K14280]
114230053  U6 spliceosomal RNA [KO:K14280]
129150829  U6 spliceosomal RNA [KO:K14280]
114232274  U6 spliceosomal RNA [KO:K14280]
114227117  U6 spliceosomal RNA [KO:K14280]
129148912  U6 spliceosomal RNA [KO:K14280]
114233554  U6 spliceosomal RNA [KO:K14280]
114230363  U6 spliceosomal RNA [KO:K14280]
103286638  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
103300482  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
103300493  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
103284633  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
103301257  CDC40; pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
103298585  pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
129151093  PRPF18; LOW QUALITY PROTEIN: pre-mRNA-splicing factor 18 [KO:K12817]
103293056  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
103291628  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
103284879  DHX15; ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
103285612  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
103303203  SNRPD1; small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
103301379  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
129151615  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
103303288  LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
103300333  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
103297511  SNRPE; small nuclear ribonucleoprotein E isoform X2 [KO:K11097]
103288986  SNRPF; small nuclear ribonucleoprotein F isoform X1 [KO:K11098]
103295519  small nuclear ribonucleoprotein F-like [KO:K11098]
103291450  SNRPG; small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
114229175  small nuclear ribonucleoprotein G-like [KO:K11099]
114234207  small nuclear ribonucleoprotein G-like [KO:K11099]
114231058  small nuclear ribonucleoprotein G-like [KO:K11099]
129152080  small nuclear ribonucleoprotein G-like [KO:K11099]
114227427  small nuclear ribonucleoprotein G-like [KO:K11099]
114231556  small nuclear ribonucleoprotein G-like [KO:K11099]
103297640  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
103284298  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
103295529  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
103283406  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X7 [KO:K12821]
103285273  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
103283604  RBM25; RNA-binding protein 25 isoform X2 [KO:K12822]
103293131  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X2 [KO:K12823] [EC:5.6.2.7]
129151866  LOW QUALITY PROTEIN: transcription elongation regulator 1-like [KO:K12824]
103289604  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
103296231  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
129148335  SNRPA1; U2 small nuclear ribonucleoprotein A' isoform X1 [KO:K11092]
103285690  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
103286854  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
103294272  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
103294747  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
103290564  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
103290964  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
103284651  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
103298956  SF3B4; splicing factor 3B subunit 4 isoform X1 [KO:K12831]
103304503  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
103305558  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
103288825  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
103293145  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
103289792  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
129150527  LOW QUALITY PROTEIN: splicing factor U2AF 26 kDa subunit-like [KO:K12836]
103304200  U2AF2; splicing factor U2AF 65 kDa subunit isoform X3 [KO:K12837]
103297944  LOW QUALITY PROTEIN: splicing factor U2AF 65 kDa subunit-like [KO:K12837]
103302707  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
103288554  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
103298586  RBM17; splicing factor 45 [KO:K12840]
103300890  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X2 [KO:K12841]
103304241  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
103294365  RP9; retinitis pigmentosa 9 protein [KO:K19604]
129151414  retinitis pigmentosa 9 protein-like [KO:K19604]
114232907  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
103300529  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
103295950  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
129149747  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
129149761  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
103292650  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
103299546  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
103291421  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
129151263  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
103288193  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
103294414  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
103295933  LSM8; LSM8 homolog, U6 small nuclear RNA associated isoform X2 [KO:K12627]
103298966  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
103291334  U4/U6 small nuclear ribonucleoprotein Prp3-like [KO:K12843]
103303922  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
103294842  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
103303679  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
103288819  SNU13; NHP2-like protein 1 [KO:K12845]
129150738  NHP2-like protein 1 [KO:K12845]
103304725  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
103299077  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
103290967  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
103285812  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
103284020  PRPF38A; pre-mRNA-splicing factor 38A isoform X1 [KO:K12849]
103291136  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
103293218  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
103299670  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
103300265  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
103291766  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
103292046  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X1 [KO:K12857]
103285250  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
103303292  TXNL4A; thioredoxin-like protein 4A isoform X2 [KO:K12859]
103302553  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
103296615  CDC5L; cell division cycle 5-like protein isoform X1 [KO:K12860]
103303188  cell division cycle 5-like protein [KO:K12860]
103291208  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
103288475  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
103292944  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
103293305  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
129151123  beta-catenin-like protein 1 [KO:K12864]
129151124  beta-catenin-like protein 1 [KO:K12864]
129151125  beta-catenin-like protein 1 [KO:K12864]
129151126  beta-catenin-like protein 1 [KO:K12864]
129151128  beta-catenin-like protein 1 [KO:K12864]
129151130  beta-catenin-like protein 1 [KO:K12864]
129151131  beta-catenin-like protein 1 [KO:K12864]
129151132  beta-catenin-like protein 1 [KO:K12864]
129151133  beta-catenin-like protein 1 [KO:K12864]
129151134  beta-catenin-like protein 1 [KO:K12864]
129151135  beta-catenin-like protein 1 [KO:K12864]
129151137  beta-catenin-like protein 1 [KO:K12864]
129151138  beta-catenin-like protein 1 [KO:K12864]
129151139  beta-catenin-like protein 1 [KO:K12864]
103300460  heat shock 70 kDa protein 1-like [KO:K03283]
103300527  heat shock 70 kDa protein 1-like [KO:K03283]
103304878  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
103301961  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
103300528  heat shock 70 kDa protein 1 [KO:K03283]
103297281  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
103301290  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
103285111  WBP11; WW domain-binding protein 11 isoform X1 [KO:K12866]
103283531  SNW1; SNW domain-containing protein 1 [KO:K06063]
103294996  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
103291937  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
103285708  CRNKL1; crooked neck-like protein 1 isoform X1 [KO:K12869]
103304364  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
103295502  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
103294767  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
103299147  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
103291575  coiled-coil domain-containing protein 12-like [KO:K12871]
103295756  RBM22; pre-mRNA-splicing factor RBM22 isoform X2 [KO:K12872]
103287950  LOW QUALITY PROTEIN: pre-mRNA-splicing factor RBM22-like [KO:K12872]
129147001  BUD31; protein BUD31 homolog [KO:K12873]
103287286  AQR; RNA helicase aquarius [KO:K12874]
103301518  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
103298370  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103296532  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
103284007  MAGOH; protein mago nashi homolog [KO:K12877]
103285088  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
103303127  THOC1; THO complex subunit 1 [KO:K12878]
103284186  THO complex subunit 2 [KO:K12879]
103301905  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
103291535  THOC3; THO complex subunit 3 [KO:K12880]
103298348  ALYREF; THO complex subunit 4 [KO:K12881]
103286407  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
103303538  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
129150641  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
103285366  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
103283288  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
129150697  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
103302763  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
103302107  RBMX; RNA-binding motif protein, X chromosome isoform X2 [KO:K12885]
103286502  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
103295040  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X6 [KO:K12887]
103299094  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M-like [KO:K12887]
103301074  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
103291454  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
103291656  SRSF1; serine/arginine-rich splicing factor 1 isoform X3 [KO:K12890]
103298257  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
103297874  serine/arginine-rich splicing factor 2-like [KO:K12891]
103295503  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
103283622  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
103291864  SRSF4; serine/arginine-rich splicing factor 4 isoform X2 [KO:K12893]
103301528  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
103305454  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103287105  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
103291951  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
103300667  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
103300072  LOW QUALITY PROTEIN: transformer-2 protein homolog beta-like [KO:K12897]
129147594  LOW QUALITY PROTEIN: transformer-2 protein homolog beta-like [KO:K12897]
103291946  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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