KEGG   PATHWAY: egz04115
Entry
egz04115                    Pathway                                
Name
p53 signaling pathway - Egretta garzetta (little egret)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
egz04115  p53 signaling pathway
egz04115

Organism
Egretta garzetta (little egret) [GN:egz]
Gene
104130058  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
104122580  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
104127113  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
104129228  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
104132103  GORAB; RAB6-interacting golgin [KO:K19748]
104132910  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104125743  MDM4; protein Mdm4 [KO:K10127]
104131411  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104124226  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
104124192  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
104124693  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104124210  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
104125735  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
104128955  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104125564  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
104125860  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
104134882  SFN; 14-3-3 protein sigma [KO:K06644]
104124904  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
104130767  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
104124647  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
104126926  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104123784  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
104129042  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104127053  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
104123536  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
104130511  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104134395  BID; BH3-interacting domain death agonist [KO:K04726]
104133908  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
104125656  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
104130016  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
104129571  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
104129229  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
104124341  SHISA5; protein shisa-5 [KO:K10135]
104131192  p53 apoptosis effector related to PMP-22-like [KO:K10136]
104131193  p53 apoptosis effector related to PMP-22-like [KO:K10136]
104129990  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
104125553  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
104132707  cytochrome c, somatic [KO:K08738]
104126145  cytochrome c [KO:K08738]
104132316  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
104133155  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
104129473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104124601  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
104125967  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
104135582  IGF1; insulin-like growth factor I [KO:K05459]
104134054  CD82; CD82 antigen [KO:K06509]
104122092  THBS1; thrombospondin-1 [KO:K16857]
104122813  SERPINB5; serpin B5 [KO:K10139]
104134072  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
104125884  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104127145  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104131717  SESN3; sestrin-3 [KO:K10141]
104124288  uncharacterized protein CXorf65 homolog [KO:K10141]
104131563  SESN1; sestrin-1 [KO:K10141]
104132553  SESN2; sestrin-2 [KO:K20394]
104125131  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104127720  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104128119  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
104129725  RFWD2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
104135718  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
104133644  CCNG1; cyclin-G1 [KO:K10145]
104128687  CCNG2; cyclin-G2 [KO:K10146]
104121876  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
egz04110  Cell cycle
egz04210  Apoptosis
egz04218  Cellular senescence
KO pathway
ko04115   
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