KEGG   PATHWAY: ggn03320
Entry
ggn03320                    Pathway                                
Name
PPAR signaling pathway - Gavialis gangeticus (Gharial)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
ggn03320  PPAR signaling pathway
ggn03320

Organism
Gavialis gangeticus (Gharial) [GN:ggn]
Gene
109292179  CD36; platelet glycoprotein 4 [KO:K06259]
109295039  SLC27A1; long-chain fatty acid transport protein 1 isoform X1 [KO:K08745] [EC:6.2.1.-]
109292913  SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
109288313  SLC27A2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
109297493  long-chain fatty acid transport protein 6-like isoform X1 [KO:K08749]
109297494  SLC27A6; long-chain fatty acid transport protein 6 isoform X1 [KO:K08749]
109304151  FABP1; fatty acid-binding protein, liver [KO:K08750]
109300974  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
109304988  fatty acid-binding protein, adipocyte-like [KO:K08753]
109304986  myelin P2 protein-like [KO:K08754]
109290084  FABP6; gastrotropin [KO:K08755]
109299546  FABP7; fatty acid-binding protein, brain [KO:K08756]
109296524  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
109293020  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109287008  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
109295344  PPARD; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta [KO:K04504]
109289149  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
109287047  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:2.3.3.10]
109297851  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
109294134  APOA1; apolipoprotein A-I [KO:K08757]
109294142  apolipoprotein C-III-like [KO:K08759]
109294145  APOA5; apolipoprotein A-V isoform X1 [KO:K09025]
109292475  PLTP; phospholipid transfer protein [KO:K08761]
109302830  ME3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
109299908  ME1; NADP-dependent malic enzyme isoform X1 [KO:K00029] [EC:1.1.1.40]
109295789  FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.3]
109287430  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
109303996  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
109298757  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
109291179  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
109298893  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
109301588  sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
109293410  acyl-CoA-binding protein-like [KO:K08762]
109301386  DBI; acyl-CoA-binding protein [KO:K08762]
109297392  LPL; lipoprotein lipase isoform X1 [KO:K01059] [EC:3.1.1.34]
109287617  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
109300739  ACSL4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
109301037  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
109288199  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
109289971  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
109294848  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
109288704  ACSBG1; long-chain-fatty-acid--CoA ligase ACSBG1 [KO:K15013] [EC:6.2.1.3]
109287805  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
109291199  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
109286645  SCP2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
109287896  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
109303775  peroxisomal acyl-coenzyme A oxidase 3-like isoform X1 [KO:K00232] [EC:1.3.3.6]
109303776  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
109289012  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:1.17.99.3]
109299242  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
109286641  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
109297225  carnitine O-palmitoyltransferase 2, mitochondrial-like isoform X1 [KO:K08766] [EC:2.3.1.21]
109301990  ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00255] [EC:1.3.8.8]
109287399  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
109288522  PLIN1; perilipin-1 isoform X1 [KO:K08768]
109297621  PLIN2; perilipin-2 isoform X1 [KO:K17284]
109287857  adiponectin-like [KO:K07296]
109303295  neutrophil collagenase-like [KO:K01388] [EC:3.4.24.7]
109303296  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
109303297  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
109303308  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
109294444  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
109292647  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
109302601  GK; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
109297983  aquaporin-7-like [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
ggn00071  Fatty acid degradation
ggn00120  Primary bile acid biosynthesis
ggn00564  Glycerophospholipid metabolism
ggn04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

DBGET integrated database retrieval system