KEGG   PATHWAY: hhv00830
Entry
hhv00830                    Pathway                                
Name
Retinol metabolism - Hyaena hyaena (striped hyena)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hhv00830  Retinol metabolism
hhv00830

Other DBs
GO: 0006776
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120228696  BCO1; LOW QUALITY PROTEIN: beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
120246622  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
120246619  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
120231866  LOW QUALITY PROTEIN: alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120246611  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
120224913  DHRS3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
120247028  dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
120242855  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
120244457  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
120235876  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
120237440  RDH11; retinol dehydrogenase 11 isoform X1 [KO:K11152] [EC:1.1.1.300]
120237433  RDH12; retinol dehydrogenase 12 [KO:K11153] [EC:1.1.1.300]
120239761  RDH13; retinol dehydrogenase 13 isoform X1 [KO:K11161] [EC:1.1.1.300]
120224882  RDH16; retinol dehydrogenase 16 isoform X1 [KO:K11154] [EC:1.1.1.-]
120222469  SDR16C5; epidermal retinol dehydrogenase 2 isoform X1 [KO:K15734] [EC:1.1.1.105]
120224864  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
120221623  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
120246564  DGAT1; diacylglycerol O-acyltransferase 1 isoform X1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
120246057  AWAT2; acyl-CoA wax alcohol acyltransferase 2 isoform X1 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
120235974  PNPLA4; patatin-like phospholipase domain-containing protein 4 [KO:K11157] [EC:3.1.1.-]
120220328  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
120219944  RDH5; retinol dehydrogenase 5 [KO:K00061] [EC:1.1.1.315]
120220681  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
120238019  ALDH1A1; retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
120233703  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
120230876  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
120230610  cytochrome P450 26A1 [KO:K07437] [EC:1.14.14.-]
120248510  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
120230550  cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
120235772  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
120235751  LOW QUALITY PROTEIN: cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
120241873  LOW QUALITY PROTEIN: cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
120239758  LOW QUALITY PROTEIN: cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
120243430  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
120230588  cytochrome P450 2C41-like [KO:K07413] [EC:1.14.14.1]
120230589  cytochrome P450 2C41-like isoform X1 [KO:K07413] [EC:1.14.14.1]
120230594  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
120240193  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
120225539  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
120227384  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
120227978  cytochrome P450 3A12-like isoform X1 [KO:K07424] [EC:1.14.14.1]
120227918  cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
120226329  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120227720  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120227630  LOW QUALITY PROTEIN: cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
120233357  UDP-glucuronosyltransferase 1A1-like [KO:K00699] [EC:2.4.1.17]
120233379  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
120222184  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
120244970  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
120220476  RETSAT; all-trans-retinol 13,14-reductase isoform X1 [KO:K09516] [EC:1.3.99.23]
120245941  cytochrome P450 27C1 isoform X1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
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