KEGG PATHWAY: loc00260

PATHWAY: loc00260

Entry

loc00260                    Pathway

Name

Glycine, serine and threonine metabolism - Lepisosteus oculatus (spotted gar)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

loc00260

Glycine, serine and threonine metabolism

Module

loc_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:loc00260]

loc_M00047

Creatine pathway [PATH:loc00260]

loc_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:loc00260]

loc_M00555

Betaine biosynthesis, choline => betaine [PATH:loc00260]

loc_M00974

Betaine metabolism, animals, betaine => glycine [PATH:loc00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Lepisosteus oculatus (spotted gar) [GN:loc]

Gene

102690077

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

102697317

shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

102685440

shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

102686638

agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

102689111

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102694674

glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]

102682955

pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

102690514

bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

102692497

phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

102692184

psat1; LOW QUALITY PROTEIN: phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

102695365

psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

102696548

L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]

102689727

L-threonine 3-dehydrogenase, mitochondrial-like isoform X1 [KO:K15789] [EC:1.1.1.103]

102686312

5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

102685240

5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

102688036

alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

102686372

LOW QUALITY PROTEIN: amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]

102691383

probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]

102698142

amine oxidase [flavin-containing] B-like isoform X1 [KO:K00274] [EC:1.4.3.4]

102694963

primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]

102686049

gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

102692412

dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

102697265

gcsh; glycine cleavage system H protein, mitochondrial isoform X2 [KO:K02437]

102688406

dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

102682826

agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

102689047

gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

102690964

gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

102694289

chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

102696035

aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

102689652

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

102682151

dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

102686175

pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

102683068

sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

102697278

gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

102682531

cbs; cystathionine beta-synthase isoform X2 [KO:K01697] [EC:4.2.1.22]

102694824

cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

102689387

L-threonine ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]

102698247

sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102698451

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

102683948

D-threo-3-hydroxyaspartate dehydratase-like isoform X1 [KO:K20498] [EC:4.3.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721