Entry
Name
Dopaminergic synapse - Monodelphis domestica (gray short-tailed opossum)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:
mdo ]
Gene
100018285 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379 ]
100029582 guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
100017208 CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048 ]
100020067 CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048 ]
100022547 CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048 ]
100015046 CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048 ]
100017341 PPP1R1B; protein phosphatase 1 regulatory inhibitor subunit 1B [KO:K15494 ]
100021421 CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850 ]
100014450 CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851 ]
100021108 CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344 ]
100023896 CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849 ]
100014566 KCNJ3; potassium voltage-gated channel subfamily J member 3 [KO:K04997 ]
100019404 KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000 ]
100029817 KCNJ9; potassium voltage-gated channel subfamily J member 9 [KO:K05002 ]
100020905 KCNJ5; potassium voltage-gated channel subfamily J member 5 [KO:K04999 ]
100010184 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347 ]
100026516 PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456 ]
100028805 PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456 ]
100023749 PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354 ]
100014202 PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354 ]
100018121 PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354 ]
100023958 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
100011289 PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583 ]
100011688 PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583 ]
100016573 PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583 ]
100017824 PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584 ]
100010758 PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584 ]
100022186 PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584 ]
100016488 PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584 ]
100018255 GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209 ]
100017355 GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210 ]
100029673 GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197 ]
100023645 GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198 ]
100030019 GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199 ]
100027109 GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200 ]
100021673 ARNTL; aryl hydrocarbon receptor nuclear translocator like [KO:K02296 ]
Compound
C00355 3,4-Dihydroxy-L-phenylalanine
C01161 3,4-Dihydroxyphenylacetate
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Beaulieu JM, Gainetdinov RR
Title
The physiology, signaling, and pharmacology of dopamine receptors.
Journal
Reference
Authors
Neve KA, Seamans JK, Trantham-Davidson H
Title
Dopamine receptor signaling.
Journal
Reference
Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
Journal
Reference
Authors
Knab AM, Lightfoot JT
Title
Does the difference between physically active and couch potato lie in the dopamine system?
Journal
Reference
Authors
Greengard P, Allen PB, Nairn AC
Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
Journal
Reference
Authors
Hu XT, Dong Y, Zhang XF, White FJ
Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
Journal
Reference
Authors
Beaulieu JM, Gainetdinov RR, Caron MG
Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
Journal
Reference
Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
Journal
Reference
Authors
Seamans JK, Yang CR
Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
Journal
Reference
Authors
Yao WD, Spealman RD, Zhang J
Title
Dopaminergic signaling in dendritic spines.
Journal
Reference
Authors
Li YC, Gao WJ
Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
Journal
Reference
Authors
Tang TS, Bezprozvanny I
Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
Journal
Reference
Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
Journal
Reference
Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
Title
Dopamine receptors: from structure to function.
Journal
Reference
Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
Journal
Related pathway
KO pathway
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