KEGG   PATHWAY: mety00270
Entry
mety00270                   Pathway                                
Name
Cysteine and methionine metabolism - Phytobacter sp. MRY16-398
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
mety00270  Cysteine and methionine metabolism
mety00270

Module
mety_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:mety00270]
mety_M00021  Cysteine biosynthesis, serine => cysteine [PATH:mety00270]
mety_M00034  Methionine salvage pathway [PATH:mety00270]
mety_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mety00270]
Other DBs
GO: 0006534 0006555
Organism
Phytobacter sp. MRY16-398 [GN:mety]
Gene
MRY16398_01430  cysE; serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]
MRY16398_08340  putative colanic acid biosynthesis acetyltransferase wcaB [KO:K00640] [EC:2.3.1.30]
MRY16398_43940  cysteine synthase [KO:K01738] [EC:2.5.1.47]
MRY16398_14730  cysteine synthase [KO:K01738] [EC:2.5.1.47]
MRY16398_09620  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
MRY16398_15450  metC; cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
MRY16398_07630  cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]
MRY16398_09630  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
MRY16398_53450  methionine synthase [KO:K00548] [EC:2.1.1.13]
MRY16398_24100  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
MRY16398_54210  metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
MRY16398_08920  metK; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
MRY16398_46960  speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
MRY16398_46950  speE; polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]
MRY16398_46380  mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]
MRY16398_41320  mtnK; methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
MRY16398_12280  yfiH; laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
MRY16398_41310  mtnA; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
MRY16398_41190  mtnB; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
MRY16398_41200  mtnC; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
MRY16398_41210  mtnD; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
MRY16398_06670  tyrB; aminotransferase [KO:K00832] [EC:2.6.1.57]
MRY16398_52450  aminotransferase [KO:K00832] [EC:2.6.1.57]
MRY16398_06600  diaminopimelate aminotransferase [KO:K08969] [EC:2.6.1.117]
MRY16398_34800  hypothetical protein [KO:K08968] [EC:1.8.4.14]
MRY16398_p11400  cytosine-specific methyltransferase [KO:K00558] [EC:2.1.1.37]
MRY16398_19450  dcm; DNA methyltransferase [KO:K00558] [EC:2.1.1.37]
MRY16398_24660  hypothetical protein [KO:K00558] [EC:2.1.1.37]
MRY16398_11600  cytosine-specific methyltransferase [KO:K00558] [EC:2.1.1.37]
MRY16398_35280  dcm; DNA methyltransferase [KO:K00558] [EC:2.1.1.37]
MRY16398_11330  luxS; S-ribosylhomocysteine lyase [KO:K07173] [EC:4.4.1.21]
MRY16398_06640  luxS; S-ribosylhomocysteine lyase [KO:K07173] [EC:4.4.1.21]
MRY16398_28440  lysC; aspartokinase [KO:K00928] [EC:2.7.2.4]
MRY16398_53320  lysC; aspartokinase [KO:K00928] [EC:2.7.2.4]
MRY16398_48260  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
MRY16398_55110  bifunctional aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
MRY16398_03670  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MRY16398_53510  metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]
MRY16398_55120  cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]
MRY16398_54730  ilvE; branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]
MRY16398_11320  gshA; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]
MRY16398_08770  gshB; glutathione synthetase [KO:K01920] [EC:6.3.2.3]
MRY16398_38060  aminotransferase [KO:K00813] [EC:2.6.1.1]
MRY16398_13710  sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
MRY16398_27470  ldh2; L-lactate dehydrogenase 2 [KO:K00016] [EC:1.1.1.27]
MRY16398_09730  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
MRY16398_20370  dcyD; D-cysteine desulfhydrase [KO:K05396] [EC:4.4.1.15]
MRY16398_05400  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
MRY16398_50810  1-aminocyclopropane-1-carboxylate deaminase [KO:K17950] [EC:4.4.1.25]
MRY16398_34600  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MRY16398_10130  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
MRY16398_53430  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
MRY16398_14680  cysteine synthase [KO:K12339] [EC:2.5.1.144]
MRY16398_09040  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MRY16398_03120  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MRY16398_38270  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
MRY16398_07690  serC-2; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
mety00010  Glycolysis / Gluconeogenesis
mety00250  Alanine, aspartate and glutamate metabolism
mety00260  Glycine, serine and threonine metabolism
mety00290  Valine, leucine and isoleucine biosynthesis
mety00430  Taurine and hypotaurine metabolism
mety00480  Glutathione metabolism
mety00620  Pyruvate metabolism
mety00640  Propanoate metabolism
mety00770  Pantothenate and CoA biosynthesis
mety00900  Terpenoid backbone biosynthesis
mety00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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