Entry
Name
Progesterone-mediated oocyte maturation - Miniopterus natalensis (Natal long-fingered bat)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
mna04914 Progesterone-mediated oocyte maturation
Ortholog table
Other DBs
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene
107526728 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
107529317 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
107535325 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
107532628 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107538463 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
107541106 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107545320 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
107540752 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
107545079 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
107539248 CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602 ]
107533909 CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602 ]
107530440 CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602 ]
107543254 CPEB3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602 ]
107535809 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
107537043 MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679 ]
107528423 MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
107540988 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
107530322 CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350 ]
107541233 ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351 ]
107529590 ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352 ]
107523893 CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353 ]
107529596 ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354 ]
107530120 CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355 ]
107532521 ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357 ]
107535457 CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359 ]
107541142 ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Schmitt A, Nebreda AR.
Title
Signalling pathways in oocyte meiotic maturation.
Journal
J Cell Sci 115:2457-9 (2002)
Reference
Authors
Cato AC, Nestl A, Mink S.
Title
Rapid actions of steroid receptors in cellular signaling pathways.
Journal
Reference
Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal
Reference
Authors
Nebreda AR, Ferby I.
Title
Regulation of the meiotic cell cycle in oocytes.
Journal
Reference
Authors
Ferrell JE Jr.
Title
Xenopus oocyte maturation: new lessons from a good egg.
Journal
Reference
Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal
Reference
Authors
Duckworth BC, Weaver JS, Ruderman JV.
Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal
Reference
Authors
Abrieu A, Doree M, Fisher D.
Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal
J Cell Sci 114:257-67 (2001)
Related pathway
KO pathway
LinkDB
All DBs