Entry
Name
Cardiac muscle contraction - Mus pahari (shrew mouse)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110317086 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
110325961 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
110313596 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
110322010 Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
110332782 Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
110318390 Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
110334476 Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864 ]
110317586 Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
110316372 Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
110327210 Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
110325173 Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
110316341 Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861 ]
110332646 Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
110334833 Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
110328680 Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
110331734 Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
110332156 Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
110337070 Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871 ]
110336489 Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
110336849 Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873 ]
110335215 Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450 ]
110312960 Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
110323660 cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416 ]
110319299 cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263 ]
110337554 cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263 ]
110335711 LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270 ]
110321497 Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
110331574 Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
110327684 Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
110327737 Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538 ]
Compound
Reference
Authors
Bers DM
Title
Calcium cycling and signaling in cardiac myocytes.
Journal
Reference
Authors
Bers DM
Title
Cardiac excitation-contraction coupling.
Journal
Reference
Authors
Endoh M
Title
Signal transduction and Ca2+ signaling in intact myocardium.
Journal
Reference
Authors
Endoh M
Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Journal
Reference
Authors
Bers DM, Despa S
Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
Journal
Reference
Authors
Gordon AM, Homsher E, Regnier M
Title
Regulation of contraction in striated muscle.
Journal
Reference
Authors
Phrommintikul A, Chattipakorn N
Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
Journal
Reference
Authors
Lacinova L
Title
Voltage-dependent calcium channels.
Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
Journal
Reference
Authors
Berg JS, Powell BC, Cheney RE
Title
A millennial myosin census.
Journal
Reference
Authors
Parmacek MS, Solaro RJ
Title
Biology of the troponin complex in cardiac myocytes.
Journal
Reference
Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Journal
Reference
Authors
Pritchard TJ, Kranias EG
Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
Journal
Reference
Authors
Landstrom AP, Dobrev D, Wehrens XHT
Title
Calcium Signaling and Cardiac Arrhythmias.
Journal
Related pathway
KO pathway
LinkDB
All DBs