KEGG   PATHWAY: mpah04020
Entry
mpah04020                   Pathway                                
Name
Calcium signaling pathway - Mus pahari (shrew mouse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04020  Calcium signaling pathway
mpah04020

Other DBs
GO: 0019722
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312799  P2rx4; P2X purinoceptor 4 isoform X1 [KO:K05218]
110312841  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
110312876  Nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
110312881  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110312899  P2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
110312939  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
110312948  Orai2; protein orai-2 isoform X1 [KO:K16057]
110312963  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
110312993  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
110313023  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
110313330  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
110313360  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
110313362  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110313439  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110313588  [KO:K04258]
110313596  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110313621  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
110313699  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
110313900  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
110314005  Fgf16; fibroblast growth factor 16 [KO:K04358]
110314008  Grpr; gastrin-releasing peptide receptor [KO:K04169]
110314023  Cysltr1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
110315110  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110315801  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110315948  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110316104  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110316234  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110316284  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110316339  [KO:K26467]
110316577  Tgfa; protransforming growth factor alpha [KO:K08774]
110316609  Tacr1; substance-P receptor [KO:K04222]
110316713  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110316786  [KO:K10785]
110316991  Hrh1; histamine H1 receptor [KO:K04149]
110317052  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
110317086  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110317154  Fgf6; fibroblast growth factor 6 [KO:K04358]
110317210  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110317216  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
110317251  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110317253  Oxtr; oxytocin receptor [KO:K04229]
110317286  Fgf23; fibroblast growth factor 23 [KO:K22428]
110317395  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
110317699  [KO:K04632]
110317700  [KO:K04632]
110317705  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
110317706  Orai3; protein orai-3 isoform X1 [KO:K16058]
110317815  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
110318209  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110318415  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110318463  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
110318603  Fgf7; fibroblast growth factor 7 [KO:K04358]
110318607  P2rx3; P2X purinoceptor 3 [KO:K05217]
110318738  Tnnc2; troponin C, skeletal muscle [KO:K12042]
110318980  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
110319080  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
110319175  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110319211  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
110319261  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110319271  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
110319274  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110319364  Ntsr1; neurotensin receptor type 1 [KO:K04211]
110319506  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
110319646  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110319649  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110319787  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110319912  Casq2; calsequestrin-2 isoform X1 [KO:K23445]
110319957  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110320075  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110320203  Mcoln2; mucolipin-2 isoform X1 [KO:K04993]
110320322  Mcoln3; mucolipin-3 isoform X1 [KO:K04994]
110320362  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
110320512  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
110320542  Tacr3; neuromedin-K receptor [KO:K04224]
110320569  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110320585  Ngf; beta-nerve growth factor [KO:K02582]
110320635  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
110320654  Agtr1; type-1 angiotensin II receptor [KO:K04166]
110320746  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
110320747  C4H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
110320782  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
110320932  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110321008  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110321178  Casq1; calsequestrin-1 [KO:K23468]
110321218  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
110321248  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110321310  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
110321516  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
110321576  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
110321647  Atp2b4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
110321797  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
110322010  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110322413  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110322554  [KO:K04161]
110322582  Avpr1b; vasopressin V1b receptor [KO:K04227]
110322699  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
110322746  Ptafr; platelet-activating factor receptor [KO:K04279]
110322986  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
110322987  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110323262  Chrna7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
110323509  Ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
110323710  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110323713  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110324185  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
110324261  Calm1; calmodulin [KO:K02183]
110324646  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
110324855  Bdkrb2; B2 bradykinin receptor isoform X1 [KO:K03916]
110325005  Bdkrb1; B1 bradykinin receptor [KO:K03915]
110325335  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110325338  Ednrb; endothelin B receptor [KO:K04198]
110325367  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110325370  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110325439  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110325518  Fgf9; fibroblast growth factor 9 [KO:K04358]
110325574  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110325595  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
110325628  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
110325648  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110325664  Tpcn2; two pore calcium channel protein 2 [KO:K14077]
110325751  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
110325784  Adra1a; alpha-1A adrenergic receptor [KO:K04135]
110325890  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
110325891  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
110325924  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
110325961  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110326013  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110326151  Mrln; myoregulin [KO:K22643]
110326239  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
110326297  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110326314  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110326448  Pln; cardiac phospholamban [KO:K05852]
110326449  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110326486  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110326646  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
110326786  Adora2a; adenosine receptor A2a [KO:K04266]
110326812  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
110326860  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110326868  Tacr2; substance-K receptor [KO:K04223]
110326927  Avpr1a; vasopressin V1a receptor [KO:K04226]
110326986  Tbxa2r; thromboxane A2 receptor [KO:K04264]
110327081  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110327824  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
110327924  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110327962  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110327986  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
110328011  Mst1; hepatocyte growth factor-like protein [KO:K23441]
110328293  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110328564  Sln; sarcolipin [KO:K22642]
110328624  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
110328764  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110328985  F2r; proteinase-activated receptor 1 [KO:K03914]
110329057  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110329060  Fgf10; fibroblast growth factor 10 [KO:K04358]
110329076  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
110329346  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110329624  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110329666  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
110329701  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110330463  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110330477  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110330584  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110330593  Stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
110330776  Ryr1; ryanodine receptor 1 [KO:K04961]
110330786  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110330788  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110330906  Drd5; D(1B) dopamine receptor [KO:K05840]
110330907  Cckar; cholecystokinin receptor type A [KO:K04194]
110330967  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
110331006  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110331028  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110331248  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
110331339  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110331342  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
110331408  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
110331550  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110331704  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
110331735  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
110331743  Smim6; small integral membrane protein 6 [KO:K26468]
110331831  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110332000  Fgf18; fibroblast growth factor 18 [KO:K04358]
110332008  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
110332026  P2rx5; P2X purinoceptor 5 [KO:K05219]
110332027  P2rx1; P2X purinoceptor 1 [KO:K05215]
110332124  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110332126  Cckbr; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
110332158  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
110332259  Adora2b; adenosine receptor A2b [KO:K04267]
110332714  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110332832  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110332897  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
110333017  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110333064  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
110333065  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110333240  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
110333309  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110333506  Adrb2; beta-2 adrenergic receptor [KO:K04142]
110333600  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110333755  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
110333803  Adrb1; beta-1 adrenergic receptor [KO:K04141]
110333959  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
110333989  [KO:K04166]
110333996  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110334127  Hrh2; histamine H2 receptor isoform X1 [KO:K04150]
110334129  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110334152  Drd1; D(1A) dopamine receptor [KO:K04144]
110334170  Calml3; calmodulin-like protein 3 [KO:K02183]
110334182  [KO:K02183]
110334252  Ryr2; ryanodine receptor 2 [KO:K04962]
110334502  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
110334522  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110334612  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110334904  Fgf19; fibroblast growth factor 19 [KO:K22603]
110334927  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
110335172  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
110335215  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
110335444  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110335460  Tfeb; transcription factor EB isoform X1 [KO:K15590]
110335904  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
110336102  Calm2; calmodulin isoform X1 [KO:K02183]
110336146  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
110336305  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
110336366  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
110336417  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110336466  Calm3; calmodulin [KO:K02183]
110336599  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
110336606  Fgf4; fibroblast growth factor 4 [KO:K04358]
110336671  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110336732  Vegfc; vascular endothelial growth factor C [KO:K05449]
110336807  Fgf20; fibroblast growth factor 20 [KO:K04358]
110336809  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
110336924  Mcoln1; mucolipin-1 [KO:K04992]
110336980  [KO:K04634]
110337061  Adrb3; beta-3 adrenergic receptor [KO:K04143]
110337199  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110337305  Ptger1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
110337377  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
110337392  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110337404  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110337453  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
110337577  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110337733  [KO:K04282]
110337766  Fgf3; fibroblast growth factor 3 [KO:K04358]
110337787  Phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
110337850  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
110338039  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
110338142  Trdn; triadin [KO:K23449]
110338208  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
110338229  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110338394  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110338639  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
110338839  Fgf21; fibroblast growth factor 21 [KO:K22429]
110339167  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mpah04010  MAPK signaling pathway
mpah04070  Phosphatidylinositol signaling system
mpah04210  Apoptosis
mpah04720  Long-term potentiation
mpah04730  Long-term depression
KO pathway
ko04020   

DBGET integrated database retrieval system