KEGG   PATHWAY: myb04727
Entry
myb04727                    Pathway                                
Name
GABAergic synapse - Myotis brandtii (Brandt's bat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
myb04727  GABAergic synapse
myb04727

Other DBs
GO: 0051932
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102242997  SLC38A1; solute carrier family 38 member 1 [KO:K14990]
102260745  SLC38A2; solute carrier family 38 member 2 [KO:K14207]
102243368  GLS; glutaminase [KO:K01425] [EC:3.5.1.2]
102242480  GLS2; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
102241538  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
102255123  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
102244823  SLC32A1; solute carrier family 32 member 1 [KO:K15015]
102244436  ABAT; 4-aminobutyrate aminotransferase [KO:K13524] [EC:2.6.1.19 2.6.1.22]
102258831  GABRA6; gamma-aminobutyric acid type A receptor alpha6 subunit [KO:K05175]
102259128  GABRA1; gamma-aminobutyric acid type A receptor alpha1 subunit [KO:K05175]
102261689  GABRA3; gamma-aminobutyric acid type A receptor alpha3 subunit [KO:K05175]
102248968  GABRA2; gamma-aminobutyric acid type A receptor alpha2 subunit [KO:K05175]
102250050  GABRA4; gamma-aminobutyric acid type A receptor alpha4 subunit [KO:K05175]
102250245  GABRA5; gamma-aminobutyric acid type A receptor alpha5 subunit [KO:K05175]
102251049  GABRB1; gamma-aminobutyric acid type A receptor beta1 subunit [KO:K05181]
102251333  GABRB3; gamma-aminobutyric acid type A receptor beta3 subunit [KO:K05181]
102257937  GABRB2; gamma-aminobutyric acid type A receptor beta2 subunit [KO:K05181]
102251628  GABRG3; gamma-aminobutyric acid type A receptor gamma3 subunit [KO:K05186]
102260014  GABRG2; gamma-aminobutyric acid type A receptor gamma2 subunit [KO:K05186]
102248669  GABRG1; gamma-aminobutyric acid type A receptor gamma1 subunit [KO:K05186]
102239099  GABRD; gamma-aminobutyric acid type A receptor delta subunit [KO:K05184]
102248010  GABRE; gamma-aminobutyric acid type A receptor epsilon subunit [KO:K05185]
102261206  GABRQ; gamma-aminobutyric acid type A receptor theta subunit [KO:K05192]
102261627  GABRP; gamma-aminobutyric acid type A receptor pi subunit [KO:K05189]
102244919  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102252927  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102247553  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102243136  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102249897  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102262056  GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
102259347  GABARAP; GABA type A receptor-associated protein [KO:K08341]
102255361  GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
102241084  NSF; N-ethylmaleimide sensitive factor, vesicle fusing ATPase [KO:K06027] [EC:3.6.4.6]
102249817  vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
102248073  TRAK2; trafficking kinesin protein 2 [KO:K15374]
102255001  PLCL1; phospholipase C like 1 [KO:K15375]
102255218  GPHN; gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
102246513  SLC12A5; solute carrier family 12 member 5 [KO:K23967]
102251167  GABRR1; gamma-aminobutyric acid type A receptor rho1 subunit [KO:K05190]
102257882  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
102245786  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102240225  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102259218  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102260789  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102243265  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102254844  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
102256100  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
102249318  GNAI2; G protein subunit alpha i2 [KO:K04630]
102239557  GNAI3; G protein subunit alpha i3 [KO:K04630]
102256872  GNAI1; G protein subunit alpha i1 [KO:K04630]
102263380  GNAO1; G protein subunit alpha o1 [KO:K04534]
102257321  GNB1; G protein subunit beta 1 [KO:K04536]
102257762  GNB2; G protein subunit beta 2 [KO:K04537]
102262102  GNB3; G protein subunit beta 3 [KO:K07825]
102263696  GNB4; G protein subunit beta 4 [KO:K04538]
102252218  guanine nucleotide-binding protein subunit beta-4-like [KO:K04538]
102242731  GNB5; G protein subunit beta 5 [KO:K04539]
102253997  GNG2; G protein subunit gamma 2 [KO:K07826]
102259768  GNG4; G protein subunit gamma 4 [KO:K04541]
102250530  GNG5; G protein subunit gamma 5 [KO:K04542]
102258952  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102263275  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
102238618  GNG7; G protein subunit gamma 7 [KO:K04543]
102250013  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
102263426  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102254808  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
102242875  GNG12; G protein subunit gamma 12 [KO:K04347]
102240295  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
102257413  GNG13; G protein subunit gamma 13 [KO:K04547]
102252604  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102257679  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102260356  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102261014  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102247996  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102257731  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102248773  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102253549  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102249345  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102248953  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102239566  KCNJ6; potassium voltage-gated channel subfamily J member 6 [KO:K05000]
102259217  SLC6A1; solute carrier family 6 member 1 [KO:K05034]
102247931  SLC6A13; solute carrier family 6 member 13 [KO:K05046]
102254788  SLC6A11; solute carrier family 6 member 11 [KO:K05044]
102248930  SLC6A12; solute carrier family 6 member 12 [KO:K05045]
102243515  GLUL; glutamate-ammonia ligase [KO:K01915] [EC:6.3.1.2]
102253986  SLC38A3; solute carrier family 38 member 3 [KO:K13576]
102239304  SLC38A5; solute carrier family 38 member 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
myb00020  Citrate cycle (TCA cycle)
myb00250  Alanine, aspartate and glutamate metabolism
myb04144  Endocytosis
myb04721  Synaptic vesicle cycle
KO pathway
ko04727   
LinkDB

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