Entry Name mTOR signaling pathway - Numida meleagris (helmeted guineafowl)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Organism Numida meleagris (helmeted guineafowl) [GN:
nmel ]
Gene 110404329 SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
110389791 SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995 ]
110387124 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
110398143 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
110397274 LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370 ]
110395587 RRAGD; LOW QUALITY PROTEIN: ras-related GTP-binding protein D [KO:K16186 ]
110406505 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080 ]
110407657 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081 ]
110405619 NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406 ]
110407207 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
110393798 DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
110408033 DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402 ]
110405628 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
110406092 TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137 ]
110406329 CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
110387062 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205 ]
110405362 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
110398052 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
110389204 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
110388473 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
110399294 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
110391171 low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
110401095 LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
110398220 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
110408577 DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
110399139 tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158 ]
110389564 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110388756 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
110402756 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
110398160 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
110397252 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
110408755 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
110406919 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related KO pathway LinkDB All DBs
