KEGG   PATHWAY: nmel04810
Entry
nmel04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Numida meleagris (helmeted guineafowl)
Class
Cellular Processes; Cell motility
Pathway map
nmel04810  Regulation of actin cytoskeleton
nmel04810

Other DBs
GO: 0030036
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110387131  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110387153  RGCC; regulator of cell cycle RGCC [KO:K26108]
110387318  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
110387336  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
110387478  [KO:K27976]
110387798  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
110387905  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
110388035  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110388133  NRAS; GTPase NRas [KO:K07828]
110388357  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
110388403  [KO:K06482]
110388525  [KO:K00907] [EC:2.7.11.18]
110388544  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
110388676  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
110388756  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110388854  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110388874  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
110389073  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
110389087  FGF22; fibroblast growth factor 22 [KO:K04358]
110389111  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110389118  ACTN4; alpha-actinin-4 [KO:K05699]
110389247  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
110389317  FGF9; fibroblast growth factor 9 [KO:K04358]
110389338  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
110389432  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
110389532  RDX; radixin [KO:K05762]
110389564  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110389587  ITGA1; integrin alpha-1 [KO:K06480]
110389638  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
110389787  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
110389823  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110389965  C7; complement component C7 isoform X1 [KO:K03996]
110390007  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
110390182  C6; complement component C6 [KO:K03995]
110390295  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
110390426  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110390440  [KO:K00920] [EC:2.7.1.149]
110390661  FGF23; fibroblast growth factor 23 [KO:K22428]
110390665  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
110390876  ITGB7; integrin beta-7 [KO:K06590]
110391060  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
110391114  ITGA7; integrin alpha-7 [KO:K06583]
110391240  [KO:K05730]
110391291  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110391341  [KO:K22429]
110391351  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
110391479  NCKAP1L; nck-associated protein 1-like [KO:K05750]
110391622  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
110391747  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
110392547  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
110392622  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
110392872  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110393050  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110393190  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110393246  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
110393351  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
110393361  MYH9; myosin-9 [KO:K10352]
110393412  ITGA9; integrin alpha-9 [KO:K06585]
110393421  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
110393442  FAM49B; LOW QUALITY PROTEIN: protein FAM49B [KO:K27976]
110393482  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110393676  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
110393691  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
110393711  SCIN; adseverin isoform X1 [KO:K05768]
110393818  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110393828  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
110394232  [KO:K12757]
110394311  [KO:K12757]
110394457  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110394492  ITGA8; integrin alpha-8 [KO:K06584]
110394649  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
110395385  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
110395539  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
110395626  ENAH; protein enabled homolog isoform X1 [KO:K05746]
110395840  FAM49A; protein FAM49A isoform X1 [KO:K27976]
110396013  ACTR2; actin-related protein 2 [KO:K17260]
110396062  PFN4; profilin-4 isoform X1 [KO:K05759]
110396314  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110396332  KRAS; GTPase KRas isoform X1 [KO:K07827]
110396515  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
110396620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110396674  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
110396993  EZR; ezrin isoform X1 [KO:K08007]
110397150  PFN3; profilin-3 [KO:K05759]
110397177  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110397252  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110397304  PDGFC; platelet-derived growth factor C [KO:K05450]
110397348  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
110397466  PFN2; profilin-2 [KO:K05759]
110397725  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110397811  KNG1; kininogen-1 [KO:K03898]
110398001  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
110398027  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110398111  FGF2; fibroblast growth factor 2 [KO:K18497]
110398160  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110398266  FGF20; fibroblast growth factor 20 [KO:K04358]
110398386  FGF5; fibroblast growth factor 5 [KO:K04358]
110398598  LPAR5; lysophosphatidic acid receptor 5 isoform X1 [KO:K08390]
110399042  EGF; pro-epidermal growth factor [KO:K04357]
110399206  ABI2; abl interactor 2 isoform X1 [KO:K05751]
110399304  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110399450  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
110399620  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
110399627  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
110399639  CXCL12; stromal cell-derived factor 1 [KO:K10031]
110399659  ITGB6; integrin beta-6 [KO:K06589]
110399666  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
110399818  ACTR3; actin-related protein 3 [KO:K18584]
110399841  MRAS; ras-related protein M-Ras [KO:K07831]
110399842  FN1; fibronectin isoform X1 [KO:K05717]
110399995  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110400360  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
110400372  ITGB5; integrin beta-5 [KO:K06588]
110400376  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
110400462  ITGAV; integrin alpha-V [KO:K06487]
110400515  VCL; vinculin isoform X1 [KO:K05700]
110400523  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110400558  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
110400604  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110400745  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110400761  HRAS; GTPase HRas [KO:K02833]
110400779  INS; insulin [KO:K04526]
110400859  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110400908  FGF19; fibroblast growth factor 19 [KO:K22603]
110400960  CHRM4; muscarinic acetylcholine receptor M4 isoform X1 [KO:K04132]
110400969  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
110401184  [KO:K05735] [EC:2.7.11.1]
110401472  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
110401571  FGF4; fibroblast growth factor 4 [KO:K04358]
110401655  CFL2; cofilin-2 [KO:K05765]
110401754  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
110401891  BDKRB1; B1 bradykinin receptor [KO:K03915]
110401960  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110402069  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
110402087  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
110402192  FGF3; fibroblast growth factor 3 [KO:K04358]
110402256  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110402301  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
110402366  C8A; LOW QUALITY PROTEIN: complement component C8 alpha chain [KO:K03997]
110402367  C8B; complement component C8 beta chain [KO:K03998]
110402414  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110402591  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110402756  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110402978  [KO:K26108]
110402985  FGF16; fibroblast growth factor 16 [KO:K04358]
110403000  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
110403102  MSN; moesin [KO:K05763]
110403160  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
110403309  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
110403378  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
110403650  [KO:K05692]
110403663  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
110403915  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
110404031  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110404057  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110404229  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110404454  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
110404716  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
110404723  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110404968  RHOA; transforming protein RhoA [KO:K04513]
110405193  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
110405265  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110405293  TMSB4X; thymosin beta-4 [KO:K05764]
110405391  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110405399  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
110405460  [KO:K05764]
110405535  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110405632  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110405694  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110405737  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
110405738  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
110405782  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
110406072  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
110406117  MYH11; myosin-11 isoform X1 [KO:K10352]
110406159  ACTB; actin, cytoplasmic 1 [KO:K05692]
110406180  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110406215  PXN; paxillin isoform X1 [KO:K05760]
110406265  CRKL; crk-like protein [KO:K04438]
110406307  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
110406337  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110406487  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110406552  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
110406567  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110406776  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110406785  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
110406908  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
110406963  C5; complement C5 isoform X1 [KO:K03994]
110406966  GSN; gelsolin isoform X1 [KO:K05768]
110407139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110407202  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
110407248  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
110407289  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110407291  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
110407512  MYH10; myosin-10 isoform X1 [KO:K10352]
110407586  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
110407592  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
110407619  CRK; adapter molecule crk isoform X1 [KO:K04438]
110407813  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110407909  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
110407913  [KO:K04289]
110407950  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
110408003  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110408206  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
110408280  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
110408527  CDC42; cell division control protein 42 homolog [KO:K04393]
110408747  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
110408755  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
nmel04010  MAPK signaling pathway
nmel04510  Focal adhesion
nmel04520  Adherens junction
KO pathway
ko04810   

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