KEGG   PATHWAY: oki00270
Entry
oki00270                    Pathway                                
Name
Cysteine and methionine metabolism - Oncorhynchus kisutch (coho salmon)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
oki00270  Cysteine and methionine metabolism
oki00270

Module
oki_M00034  Methionine salvage pathway [PATH:oki00270]
oki_M00035  Methionine degradation [PATH:oki00270]
oki_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:oki00270]
Other DBs
GO: 0006534 0006555
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109889160  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
109902409  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
109868389  kyat1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
109879564  kyat3; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
109870002  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
109871016  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
109890513  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
109887186  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
109868318  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
109874056  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
109889006  uncharacterized protein LOC109889006 [KO:K00547] [EC:2.1.1.10]
109885516  methionine synthase [KO:K00548] [EC:2.1.1.13]
109886805  LOW QUALITY PROTEIN: methionine synthase-like [KO:K00548] [EC:2.1.1.13]
109868329  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
109899833  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
109895937  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109892429  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
109879055  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109865431  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109873069  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
109880179  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
109873527  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
109900673  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
109866701  S-adenosylmethionine decarboxylase proenzyme-like isoform X1 [KO:K01611] [EC:4.1.1.50]
109908025  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
109872795  spermine synthase [KO:K00802] [EC:2.5.1.22]
109874012  spermine synthase-like isoform X1 [KO:K00802] [EC:2.5.1.22]
109877289  mtap; S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
109868915  lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
109880345  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
116358874  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
109886984  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
109878582  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
109868415  enolase-phosphatase E1 isoform X1 [KO:K09880] [EC:3.1.3.77]
109892426  enolase-phosphatase E1 isoform X1 [KO:K09880] [EC:3.1.3.77]
109903924  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
109867491  tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
116353633  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
109909049  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
109895585  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
109893479  DNA (cytosine-5)-methyltransferase 1 isoform X2 [KO:K00558] [EC:2.1.1.37]
109897313  DNA (cytosine-5)-methyltransferase 1-like isoform X1 [KO:K00558] [EC:2.1.1.37]
109904288  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
109894271  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
109881379  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
109869717  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
109869696  uncharacterized protein LOC109869696 isoform X1 [KO:K17399] [EC:2.1.1.37]
109869386  uncharacterized protein LOC109869386 isoform X1 [KO:K17399] [EC:2.1.1.37]
109907852  DNA (cytosine-5)-methyltransferase 3B-like isoform X2 [KO:K17399] [EC:2.1.1.37]
109908179  uncharacterized protein LOC109908179 [KO:K17399] [EC:2.1.1.37]
109896774  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
109905569  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
109875711  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
109889478  putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]
109890753  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
109891110  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
109885827  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
109879108  ahcyl2; adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
109867386  putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]
109898706  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
109864297  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
109898710  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
109892312  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
109870235  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
109899867  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
109902612  glutamate--cysteine ligase regulatory subunit isoform X1 [KO:K11205]
109882206  glutamate--cysteine ligase regulatory subunit-like isoform X1 [KO:K11205]
109908009  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
109895600  cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
109875265  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
109882343  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
109876934  aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
109898898  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
116352943  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
109895116  aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
109888368  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
109889340  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
109882441  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
109867099  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
109893199  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
109893200  3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
116375819  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
109879021  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
109867664  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
109896813  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
109889664  L-lactate dehydrogenase B-A chain isoform X2 [KO:K00016] [EC:1.1.1.27]
109889702  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
109864373  L-lactate dehydrogenase B chain [KO:K00016] [EC:1.1.1.27]
109867497  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
116372076  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
109889110  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
109865683  malate dehydrogenase, cytoplasmic isoform X2 [KO:K00025] [EC:1.1.1.37]
109885003  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
109892800  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
109872651  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
109879823  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
109894360  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
109895906  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
109870639  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109866524  D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
109881997  psat1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
oki00010  Glycolysis / Gluconeogenesis
oki00250  Alanine, aspartate and glutamate metabolism
oki00260  Glycine, serine and threonine metabolism
oki00290  Valine, leucine and isoleucine biosynthesis
oki00430  Taurine and hypotaurine metabolism
oki00480  Glutathione metabolism
oki00620  Pyruvate metabolism
oki00640  Propanoate metabolism
oki00770  Pantothenate and CoA biosynthesis
oki00900  Terpenoid backbone biosynthesis
oki00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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