KEGG   PATHWAY: omc00260
Entry
omc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Onychostoma macrolepis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
omc00260  Glycine, serine and threonine metabolism
omc00260

Module
omc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:omc00260]
omc_M00047  Creatine pathway [PATH:omc00260]
omc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:omc00260]
omc_M00555  Betaine biosynthesis, choline => betaine [PATH:omc00260]
omc_M00621  Glycine cleavage system [PATH:omc00260]
omc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:omc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Onychostoma macrolepis [GN:omc]
Gene
131551635  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
131520289  uncharacterized protein LOC131520289 isoform X1 [KO:K01620] [EC:4.1.2.48]
131542619  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
131536424  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
131532526  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
131542756  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
131536897  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
131553106  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
131542838  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
131541253  pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
131552471  pgam1a; phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
131529260  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
131534269  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
131547453  phgdh; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131541721  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
131520401  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
131536625  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
131523177  tdh2; L-threonine dehydrogenase 2 isoform X1 [KO:K15789] [EC:1.1.1.103]
131523352  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
131527628  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
131549823  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
131546322  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
131547965  si:ch211-127i16.2; LOW QUALITY PROTEIN: probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
131547269  mao; amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
131536884  aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
131540732  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
131545406  amt; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
131534905  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
131524643  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
131544518  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
131541059  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
131541060  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
131528318  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
131524423  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
131547274  LOW QUALITY PROTEIN: glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
131549858  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
131546234  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
131547733  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
131528427  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
131528434  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
131554001  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
131548321  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
131523170  gnmt; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
131547342  cbsb; cystathionine beta-synthase b isoform X1 [KO:K01697] [EC:4.2.1.22]
131539523  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
131542206  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
131542207  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
131551791  LOW QUALITY PROTEIN: L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
131522960  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
131549284  zgc:162816; D-serine dehydratase isoform X1 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
omc00010  Glycolysis / Gluconeogenesis
omc00020  Citrate cycle (TCA cycle)
omc00230  Purine metabolism
omc00250  Alanine, aspartate and glutamate metabolism
omc00270  Cysteine and methionine metabolism
omc00290  Valine, leucine and isoleucine biosynthesis
omc00330  Arginine and proline metabolism
omc00470  D-Amino acid metabolism
omc00564  Glycerophospholipid metabolism
omc00600  Sphingolipid metabolism
omc00620  Pyruvate metabolism
omc00630  Glyoxylate and dicarboxylate metabolism
omc00640  Propanoate metabolism
omc00860  Porphyrin metabolism
omc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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