Entry
Name
GABAergic synapse - Ochotona princeps (American pika)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Ochotona princeps (American pika) [GN:
opi ]
Gene
101521189 SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990 ]
101520951 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207 ]
101519973 GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175 ]
101535263 GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175 ]
101536067 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X2 [KO:K05175 ]
101519931 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175 ]
101520345 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175 ]
101517564 LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-5-like [KO:K05175 ]
101520700 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175 ]
101521533 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
101520585 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181 ]
101517107 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181 ]
101536309 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186 ]
101519526 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186 ]
101517522 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186 ]
101521024 GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184 ]
101520392 GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185 ]
101519728 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
101534555 LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit pi [KO:K05189 ]
101517619 HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647 ]
101520427 gamma-aminobutyric acid receptor-associated protein-like [KO:K08341 ]
101523275 GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
101523719 GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
101533174 SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967 ]
101535593 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
101535827 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 isoform X1 [KO:K05190 ]
101527259 GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190 ]
101520695 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3 [KO:K04344 ]
101523955 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
101536063 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
101524545 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
101519864 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
101529015 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
101526850 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615 ]
101534117 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
101525340 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
101516368 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
101531957 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
101524943 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
101525483 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
101529615 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
101536793 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825 ]
101530547 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
101532346 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
101528942 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
101528746 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
101531710 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
101521396 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
101516538 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
101516227 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
101531323 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
101531879 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
101524512 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
101519866 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
101535404 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
101531647 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
101534148 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
101525377 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
101532272 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
101516477 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046 ]
101532031 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
101516714 SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045 ]
101531722 SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576 ]
101522880 SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992 ]
Compound
Reference
Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
Title
Neuropsychopharmacology: The fifth generation of progress
Journal
Reference
Authors
Farrant M, Kaila K
Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
Journal
Reference
Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
Journal
Reference
Authors
Pinard A, Seddik R, Bettler B
Title
GABAB receptors: physiological functions and mechanisms of diversity.
Journal
Reference
Authors
Chalifoux JR, Carter AG
Title
GABAB receptor modulation of synaptic function.
Journal
Reference
Authors
Padgett CL, Slesinger PA
Title
GABAB receptor coupling to G-proteins and ion channels.
Journal
Reference
Authors
Emson PC
Title
GABA(B) receptors: structure and function.
Journal
Reference
Authors
Kornau HC
Title
GABA(B) receptors and synaptic modulation.
Journal
Reference
Authors
Jacob TC, Moss SJ, Jurd R
Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
Journal
Reference
Authors
Kneussel M
Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
Journal
Reference
Authors
Luscher B, Fuchs T, Kilpatrick CL
Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
Journal
Reference
Authors
Arancibia-Carcamo IL, Kittler JT
Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
Journal
Reference
Authors
Bak LK, Schousboe A, Waagepetersen HS
Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
Journal
Reference
Authors
Conti F, Minelli A, Melone M
Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Chebib M, Johnston GA
Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
Journal
Related pathway
opi00250 Alanine, aspartate and glutamate metabolism
KO pathway
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