KEGG   PATHWAY: plai04137
Entry
plai04137                   Pathway                                
Name
Mitophagy - animal - Poecilia latipinna (sailfin molly)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
plai04137  Mitophagy - animal
plai04137

Other DBs
GO: 0000422
Organism
Poecilia latipinna (sailfin molly) [GN:plai]
Gene
106955221  ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
106950827  pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
106953851  tomm7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
106956143  mitochondrial import receptor subunit TOM40B-like [KO:K11518]
106946890  mitochondrial import receptor subunit TOM40 homolog isoform X1 [KO:K11518]
106960378  tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
106949766  tomm20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
106941113  tomm70a; mitochondrial import receptor subunit TOM70 [KO:K17768]
106936929  park2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
106963366  march5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
106947035  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MARCH5-like [KO:K10660] [EC:2.3.2.27]
106956159  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
106950855  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106947210  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106963505  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
106956543  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
106937021  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
106945602  amfr; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
106941580  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
106941888  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
106950825  mul1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
106953690  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
106935042  huwe1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
106946279  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
106959487  arih1; E3 ubiquitin-protein ligase ARIH1 [KO:K11968] [EC:2.3.2.31]
106941386  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
106959863  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
106960225  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
106934710  mitochondrial Rho GTPase 1-A-like [KO:K07870] [EC:3.6.5.-]
106960135  rhot1; mitochondrial Rho GTPase 1 isoform X1 [KO:K07870] [EC:3.6.5.-]
106960360  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
106947540  rhot2; mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
106944929  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
106938606  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
106936219  ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K08770]
106950180  tax1bp1; tax1-binding protein 1 [KO:K21347]
106945356  tax1-binding protein 1 homolog B-like isoform X1 [KO:K21347]
106958560  sqstm1; sequestosome-1 [KO:K14381]
106945434  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
106962260  optn; optineurin [KO:K19946]
106962217  nbr1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
106939540  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
106949313  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
106945771  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
106952576  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
106946764  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
106949634  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
106956015  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
106936830  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
106939719  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
106948320  becn1; beclin-1 isoform X1 [KO:K08334]
106952033  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
106960934  usp15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
106937299  usp30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
106934467  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
106964932  bcl2l1; bcl-2-like protein 1 [KO:K04570]
106947325  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
106949356  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
106937199  csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
106945857  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
106937753  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
106959688  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
106937748  casein kinase II subunit beta-like [KO:K03115]
106958853  casein kinase II subunit beta [KO:K03115]
106960237  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
106954618  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
106941702  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
106935279  ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
106956952  FUN14 domain-containing protein 1 isoform X1 [KO:K17986]
106946397  fundc1; FUN14 domain-containing protein 1 [KO:K17986]
106947697  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
106954517  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
106955573  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
106950429  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
106960508  bcl2l13; bcl-2-like protein 13 isoform X1 [KO:K15485]
106950714  fkbp8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
106953402  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
106938999  sorting and assembly machinery component 50 homolog A [KO:K07277]
106960210  sorting and assembly machinery component 50 homolog A-like [KO:K07277]
106965138  uncharacterized protein LOC106965138 [KO:K07277]
106952751  phb2; prohibitin-2 isoform X1 [KO:K17081]
106938668  prohibitin-2-like [KO:K17081]
106960279  nlrx1; NLR family member X1 [KO:K12653]
106961923  mtx2; metaxin-2 [KO:K17776]
106935585  mtx1; metaxin-1 [KO:K17776]
106958350  mtx3; metaxin-3 isoform X1 [KO:K17776]
106963566  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
106957937  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106936789  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106964606  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106962379  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106944787  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106959048  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106954976  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106956726  transcription factor jun-D-like [KO:K04448]
106947718  jun; transcription factor AP-1 [KO:K04448]
106954325  transcription factor AP-1-like [KO:K04448]
106938010  transcription factor p65-like isoform X1 [KO:K04735]
106953713  hras; GTPase HRas [KO:K02833]
106935770  GTPase KRas isoform X1 [KO:K07827]
106951627  GTPase HRas-like [KO:K07827]
106956437  mras; ras-related protein M-Ras [KO:K07831]
106942398  ras-related protein R-Ras2-like [KO:K07830]
106936569  ras-related protein R-Ras2-like [KO:K07830]
106960645  rras2; ras-related protein R-Ras2 [KO:K07830]
106938542  e2f1; transcription factor E2F1 [KO:K17454]
106963702  hypoxia-inducible factor 1-alpha-like [KO:K08268]
106956876  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
106956674  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
106945775  tp53; cellular tumor antigen p53 [KO:K04451]
106962865  forkhead box protein O3-like [KO:K09408]
106961280  foxo3; forkhead box protein O3 [KO:K09408]
106964623  forkhead box protein O6-like [KO:K09408]
106934701  mitf; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
106936195  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
106958432  transcription factor EB-like isoform X1 [KO:K15590]
106936400  transcription factor E3-like [KO:K09105]
106957360  tfe3; transcription factor E3 isoform X1 [KO:K09105]
106942640  rabgef1; rab5 GDP/GTP exchange factor isoform X1 [KO:K20131]
106951453  rab5 GDP/GTP exchange factor-like [KO:K20131]
106952935  rab5 GDP/GTP exchange factor-like [KO:K20131]
106961574  ras-related protein Rab-5A [KO:K07887]
106939424  rab5a; ras-related protein Rab-5A [KO:K07887]
106950324  ras-related protein Rab-5B-like [KO:K07888]
106950562  ras-related protein Rab-5B-like [KO:K07888]
106949789  ras-related protein Rab-5C-like [KO:K07889]
106939465  ras-related protein Rab-5C [KO:K07889]
106957308  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
106957367  mon1a; vacuolar fusion protein MON1 homolog A [KO:K20195]
106964446  ccz1; vacuolar fusion protein CCZ1 homolog [KO:K27045]
106958411  ras-related protein Rab-7a [KO:K07897]
106953249  rab7a; ras-related protein Rab-7a [KO:K07897]
106964934  ras-related protein Rab-7a-like [KO:K07897]
106942219  tbc1d15; TBC1 domain family member 15 [KO:K20168]
106965249  tbc1d17; TBC1 domain family member 17 [KO:K19945]
106954574  fis1; mitochondrial fission 1 protein [KO:K17969]
106957500  atg9a; autophagy-related protein 9A [KO:K17907]
106964297  autophagy-related protein 9A-like [KO:K17907]
106953984  opa1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
106944587  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
106945994  transitional endoplasmic reticulum ATPase-like isoform X1 [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
plai04140  Autophagy - animal
plai04210  Apoptosis
KO pathway
ko04137   
LinkDB

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