KEGG   PATHWAY: plop00260
Entry
plop00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
plop00260  Glycine, serine and threonine metabolism
plop00260

Module
plop_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:plop00260]
plop_M00047  Creatine pathway [PATH:plop00260]
plop_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:plop00260]
plop_M00555  Betaine biosynthesis, choline => betaine [PATH:plop00260]
plop_M00621  Glycine cleavage system [PATH:plop00260]
plop_M00974  Betaine metabolism, animals, betaine => glycine [PATH:plop00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125366310  LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
125362415  Shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
125366186  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
125343815  Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
125342484  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
125346604  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
125346203  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
125347168  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
125355484  Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125340407  Psat1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
125338745  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
125358492  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
125339714  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
125342534  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
125344238  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
125343382  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125343918  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
125366371  LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
125366372  Aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
125351921  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
125342577  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
125346880  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
125360625  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
125361003  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
125367643  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
125350875  uncharacterized protein LOC125350875 [KO:K02437]
125358148  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
125365103  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
125349017  Dao; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
125367682  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125340422  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
125348503  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
125358581  Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
125359006  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
125339895  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
125339841  Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
125365488  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
125353290  Sardh; LOW QUALITY PROTEIN: sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
125352575  Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
125351424  Cbs; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
125355295  cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
125355296  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
125347981  Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125349088  Sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125365232  Srr; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
plop00010  Glycolysis / Gluconeogenesis
plop00020  Citrate cycle (TCA cycle)
plop00230  Purine metabolism
plop00250  Alanine, aspartate and glutamate metabolism
plop00270  Cysteine and methionine metabolism
plop00290  Valine, leucine and isoleucine biosynthesis
plop00330  Arginine and proline metabolism
plop00470  D-Amino acid metabolism
plop00564  Glycerophospholipid metabolism
plop00600  Sphingolipid metabolism
plop00620  Pyruvate metabolism
plop00630  Glyoxylate and dicarboxylate metabolism
plop00640  Propanoate metabolism
plop00860  Porphyrin metabolism
plop00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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