KEGG   PATHWAY: pspa00270
Entry
pspa00270                   Pathway                                
Name
Cysteine and methionine metabolism - Polyodon spathula (Mississippi paddlefish)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
pspa00270  Cysteine and methionine metabolism
pspa00270

Module
pspa_M00034  Methionine salvage pathway [PATH:pspa00270]
pspa_M00035  Methionine degradation [PATH:pspa00270]
pspa_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pspa00270]
Other DBs
GO: 0006534 0006555
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121330872  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
121327307  kynurenine--oxoglutarate transaminase 3-like isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121309726  kyat1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121320429  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
121327900  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
121305143  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
121313674  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
121321024  selenocysteine Se-methyltransferase-like isoform X1 [KO:K00547] [EC:2.1.1.10]
121327618  zgc:172121; homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
121316739  mtr; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
121297419  methionine adenosyltransferase 2 subunit beta-like isoform X1 [KO:K00789] [EC:2.5.1.6]
121325926  mat1a; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121316571  mat2al; methionine adenosyltransferase II, alpha-like [KO:K00789] [EC:2.5.1.6]
121302336  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
121303127  mat2aa; methionine adenosyltransferase II, alpha a isoform X1 [KO:K00789] [EC:2.5.1.6]
121324678  methionine adenosyltransferase 2 subunit beta-like isoform X1 [KO:K00789] [EC:2.5.1.6]
121315484  amd1; S-adenosylmethionine decarboxylase proenzyme isoform X1 [KO:K01611] [EC:4.1.1.50]
121317569  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
121328760  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
121328837  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
121302769  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
121296210  S-methyl-5'-thioadenosine phosphorylase isoform X1 [KO:K00772] [EC:2.4.2.28]
121322096  S-methyl-5'-thioadenosine phosphorylase-like isoform X1 [KO:K00772] [EC:2.4.2.28]
121320973  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
121304567  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
121329557  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
121301235  enolase-phosphatase E1-like [KO:K09880] [EC:3.1.3.77]
121316504  enoph1; enolase-phosphatase E1 isoform X1 [KO:K09880] [EC:3.1.3.77]
121317552  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
121296569  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
121325490  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
121303996  il4i1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
121324337  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121316224  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
121317350  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
121309134  dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
121315581  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121317469  DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
121298218  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
121298439  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
121320170  DNA (cytosine-5)-methyltransferase 3A-like [KO:K17399] [EC:2.1.1.37]
121319280  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
121319467  uncharacterized protein LOC121319467 [KO:K17399] [EC:2.1.1.37]
121297785  adenosylhomocysteinase B-like [KO:K01251] [EC:3.13.2.1]
121299776  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121299778  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121318156  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
121319487  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
121319950  putative adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
121318383  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
121319717  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
121305960  branched-chain-amino-acid aminotransferase, cytosolic-like [KO:K00826] [EC:2.6.1.42]
121304721  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121315753  glutamate--cysteine ligase catalytic subunit-like [KO:K11204] [EC:6.3.2.2]
121316852  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
121316854  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
121326700  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
121330503  glutamate--cysteine ligase regulatory subunit-like [KO:K11205]
121298316  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
121301124  cysteine dioxygenase type 1-like isoform X1 [KO:K00456] [EC:1.13.11.20]
121300563  cysteine dioxygenase type 1-like isoform X1 [KO:K00456] [EC:1.13.11.20]
121315234  cysteine dioxygenase type 1-like [KO:K00456] [EC:1.13.11.20]
121302759  cysteine dioxygenase type 1-like isoform X1 [KO:K00456] [EC:1.13.11.20]
121325784  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
121321912  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
121302475  got1l1; putative aspartate aminotransferase, cytoplasmic 2 isoform X1 [KO:K14454] [EC:2.6.1.1]
121325787  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
121309368  mpst; 3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121294678  L-lactate dehydrogenase A chain-like isoform X1 [KO:K00016] [EC:1.1.1.27]
121294261  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
121320113  L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
121318006  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
121329976  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
121330400  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
121316133  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
121317257  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
121305094  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
121297404  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121299528  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121299758  sdsl; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121322335  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121323376  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121318813  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
pspa00010  Glycolysis / Gluconeogenesis
pspa00250  Alanine, aspartate and glutamate metabolism
pspa00260  Glycine, serine and threonine metabolism
pspa00290  Valine, leucine and isoleucine biosynthesis
pspa00430  Taurine and hypotaurine metabolism
pspa00480  Glutathione metabolism
pspa00620  Pyruvate metabolism
pspa00640  Propanoate metabolism
pspa00770  Pantothenate and CoA biosynthesis
pspa00900  Terpenoid backbone biosynthesis
pspa00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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