Entry Name Intestinal immune network for IgA production - Rousettus aegyptiacus (Egyptian rousette)
Description The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ray04672 Intestinal immune network for IgA production
Ortholog table Other DBs Organism Rousettus aegyptiacus (Egyptian rousette) [GN:
ray ]
Gene 107497773 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
107506765 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
107506766 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
107505772 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107505773 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
107505774 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107511941 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
107511990 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
107511992 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
107511993 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
107511999 HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752 ]
107512001 HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752 ]
107507331 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
107507332 SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752 ]
107519371 CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470 ]
107506405 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
107511110 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
107506751 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
107516800 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
107505576 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
107514532 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
107519790 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
107501633 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
Compound Reference Authors Fagarasan S, Honjo T
Title Intestinal IgA synthesis: regulation of front-line body defences.
Journal Reference Authors Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
Title The immune geography of IgA induction and function.
Journal Reference Authors Kunisawa J, Kiyono H
Title A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
Journal Reference Authors Cerutti A, Rescigno M
Title The biology of intestinal immunoglobulin A responses.
Journal Reference Authors Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
Title Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
Journal Reference Authors Corthesy B
Title Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal Reference Authors Suzuki K, Fagarasan S
Title How host-bacterial interactions lead to IgA synthesis in the gut.
Journal Reference Authors Mora JR, von Andrian UH
Title Differentiation and homing of IgA-secreting cells.
Journal Reference Authors Suzuki K, Ha SA, Tsuji M, Fagarasan S
Title Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Journal Reference Authors Cerutti A
Title The regulation of IgA class switching.
Journal Related ray04612 Antigen processing and presentation
ray04660 T cell receptor signaling pathway
ray04662 B cell receptor signaling pathway
ray04670 Leukocyte transendothelial migration
KO pathway LinkDB All DBs
