KEGG   PATHWAY: rcu04120
Entry
rcu04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Ricinus communis (castor bean)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
rcu04120  Ubiquitin mediated proteolysis
rcu04120

Other DBs
GO: 0016567
Organism
Ricinus communis (castor bean) [GN:rcu]
Gene
107261207  polyubiquitin [KO:K08770]
107261143  polyubiquitin [KO:K08770]
107262154  polyubiquitin [KO:K08770]
8263164  ubiquitin-60S ribosomal protein L40 [KO:K02927]
8263197  ubiquitin-60S ribosomal protein L40 [KO:K02927]
8265906  ubiquitin-40S ribosomal protein S27a [KO:K02977]
8276474  ubiquitin-40S ribosomal protein S27a [KO:K02977]
8263100  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
8266541  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
8269205  SUMO-activating enzyme subunit 1B-1 isoform X2 [KO:K10684] [EC:6.2.1.45]
8284331  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
8271591  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
8287006  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
8274335  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
8270735  probable ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
8277046  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
8262718  ubiquitin-conjugating enzyme E2 30 isoform X1 [KO:K06689] [EC:2.3.2.23]
8276549  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
8268639  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
8267121  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
8287728  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
8280662  ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
8271553  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
8258696  ubiquitin-conjugating enzyme E2 7 isoform X2 [KO:K10575] [EC:2.3.2.23]
8281879  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
8261902  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
8287405  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
8289042  ubiquitin-conjugating enzyme E2 4 isoform X2 [KO:K10576] [EC:2.3.2.23]
8280550  ubiquitin-conjugating enzyme E2-23 kDa isoform X1 [KO:K10576] [EC:2.3.2.23]
8260989  SUMO-conjugating enzyme SCE1 [KO:K10577]
8258802  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
8284731  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
8275518  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
8264183  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
8282135  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
8258830  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
8262059  putative ubiquitin-conjugating enzyme E2 38 isoform X1 [KO:K10581] [EC:2.3.2.24]
8279507  probable ubiquitin-conjugating enzyme E2 24 isoform X1 [KO:K10581] [EC:2.3.2.24]
8258831  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
8273568  probable ubiquitin-conjugating enzyme E2 26 isoform X1 [KO:K10581] [EC:2.3.2.24]
8283673  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
8275041  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
8275785  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
8279121  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
8274871  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
8261305  E3 ubiquitin-protein ligase UPL6 isoform X1 [KO:K10589] [EC:2.3.2.26]
8283826  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
8263918  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
8280345  E3 ubiquitin-protein ligase UPL2 [KO:K10592] [EC:2.3.2.26]
8286859  E3 ubiquitin-protein ligase UPL1 isoform X1 [KO:K10592] [EC:2.3.2.26]
8281267  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
8273681  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
8283368  peptidyl-prolyl cis-trans isomerase CYP65 isoform X1 [KO:K10598] [EC:5.2.1.8]
8265736  pre-mRNA-processing factor 19 homolog 1 [KO:K10599] [EC:2.3.2.27]
8272429  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
8263515  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
8263517  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
8268629  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
8285803  E3 ubiquitin-protein ligase SINAT2 isoform X1 [KO:K04506] [EC:2.3.2.27]
8270897  E3 ubiquitin-protein ligase DIS1 isoform X1 [KO:K04506] [EC:2.3.2.27]
8260973  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
8263730  WD repeat-containing protein RUP2 [KO:K10143] [EC:2.3.2.27]
8266405  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
8262395  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
8283973  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
8287175  E3 ubiquitin-protein ligase MIEL1 isoform X1 [KO:K10144] [EC:2.3.2.27]
8275237  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
8271239  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
8287442  E4 SUMO-protein ligase PIAL1 isoform X1 [KO:K04706] [EC:2.3.2.-]
8283078  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
8275946  E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
8259356  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
8281168  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
8262419  cullin-1 [KO:K03347]
8272354  cullin-1 [KO:K03347]
8260314  SKP1-like protein 14 [KO:K03094]
8274703  SKP1-like protein 1B [KO:K03094]
8274704  SKP1-like protein 1B [KO:K03094]
8274521  SKP1-like protein 4 [KO:K03094]
8261447  SKP1-like protein 1 [KO:K03094]
8268074  SKP1-like protein 1A [KO:K03094]
8272024  SKP1-like protein 1B [KO:K03094]
8270661  F-box protein SKP2A [KO:K03875]
8284087  elongin-C [KO:K03872]
8270717  uncharacterized protein LOC8270717 [KO:K03873]
8260615  cullin-3A [KO:K03869]
8264103  cullin-4 isoform X1 [KO:K10609]
8266532  DNA damage-binding protein 1a isoform X1 [KO:K10610]
8286445  protein DAMAGED DNA-BINDING 2 [KO:K10140]
8265297  WD repeat-containing protein ATCSA-1 isoform X1 [KO:K10570]
8262656  light-mediated development protein DET1 isoform X1 [KO:K10571]
8274967  uncharacterized protein LOC8274967 isoform X1 [KO:K03358]
8281837  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
8275452  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
8283061  cell division cycle 20.1, cofactor of APC complex [KO:K03363]
8259804  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
8272495  protein FIZZY-RELATED 2 isoform X2 [KO:K03364]
8258392  protein FIZZY-RELATED 3 [KO:K03364]
8265369  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
8268305  cell division cycle protein 27 homolog B isoform X1 [KO:K03350]
8289828  anaphase-promoting complex subunit 4 [KO:K03351]
8278015  anaphase-promoting complex subunit 5 isoform X2 [KO:K03352]
8271101  anaphase-promoting complex subunit 6 isoform X1 [KO:K03353]
8289494  anaphase-promoting complex subunit 6 isoform X1 [KO:K03353]
8262405  anaphase-promoting complex subunit 7 [KO:K03354]
8258128  anaphase-promoting complex subunit 8 isoform X1 [KO:K03355]
8273391  anaphase-promoting complex subunit 10 isoform X3 [KO:K03357]
8275147  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
rcu03050  Proteasome
KO pathway
ko04120   
LinkDB

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