KEGG   PATHWAY: sanh04141
Entry
sanh04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Sinocyclocheilus anshuiensis
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sanh04141  Protein processing in endoplasmic reticulum
sanh04141

Other DBs
GO: 0030433 0034976
Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107667387  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107657870  protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
107666996  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
107673516  protein transport protein Sec61 subunit alpha-like 1 isoform X1 [KO:K10956]
107657724  protein transport protein Sec61 subunit beta-like [KO:K09481]
107687816  protein transport protein Sec61 subunit beta-like [KO:K09481]
107695412  protein transport protein Sec61 subunit gamma [KO:K07342]
107686695  protein transport protein Sec61 subunit gamma [KO:K07342]
107695396  protein transport protein Sec61 subunit gamma [KO:K07342]
107659352  translocation protein SEC62-like [KO:K12275]
107684396  translocation protein SEC62-like [KO:K12275]
107696131  translocation protein SEC63 homolog [KO:K09540]
107679486  translocation protein SEC63 homolog [KO:K09540]
107680451  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107699351  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
107658644  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
107669003  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
107663540  dad1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
107687594  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
107673085  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
107687429  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
107668300  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
107653713  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
107666808  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
107679507  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
107694749  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
107656570  tusc3; tumor suppressor candidate 3 isoform X1 [KO:K19478]
107663087  magnesium transporter protein 1-like [KO:K19478]
107689142  magnesium transporter protein 1 [KO:K19478]
107702329  tumor suppressor candidate 3-like [KO:K19478]
107654662  oligosaccharyltransferase complex subunit ostc [KO:K26501]
107655160  transmembrane protein 258 [KO:K26502]
107674840  transmembrane protein 258-like [KO:K26502]
107689467  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
107692169  mannosyl-oligosaccharide glucosidase-like isoform X1 [KO:K01228] [EC:3.2.1.106]
107656687  myosin-10-like [KO:K13999]
107654983  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107655391  LOW QUALITY PROTEIN: ribosome-binding protein 1-like [KO:K14000]
107659340  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107675545  ribosome-binding protein 1-like isoform X1 [KO:K14000]
107680960  nucleotide exchange factor SIL1-like [KO:K14001]
107680335  nucleotide exchange factor SIL1-like [KO:K14001]
107691632  hypoxia up-regulated protein 1 [KO:K09486]
107693979  hypoxia up-regulated protein 1-like [KO:K09486]
107686376  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107686377  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107686379  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
107687227  78 kDa glucose-regulated protein isoform X1 [KO:K09490] [EC:3.6.4.10]
107690604  dnaJ homolog subfamily B member 11-like [KO:K09517]
107659888  dnaJ homolog subfamily B member 11 [KO:K09517]
107688438  dnaJ homolog subfamily C member 1-like [KO:K09521]
107689420  dnaJ homolog subfamily C member 1-like [KO:K09521]
107702051  dnaJ homolog subfamily C member 3-like [KO:K09523]
107663878  dnaJ homolog subfamily C member 3-like [KO:K09523]
107683555  dnaJ homolog subfamily C member 3-like [KO:K09523]
107676092  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107699025  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
107658810  endoplasmin [KO:K09487]
107656288  endoplasmin-like [KO:K09487]
107662060  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
107676501  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107680629  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107702959  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
107674703  prkcsh; glucosidase 2 subunit beta [KO:K08288]
107703311  glucosidase 2 subunit beta-like [KO:K08288]
107676447  canx; calnexin isoform X1 [KO:K08054]
107667459  calnexin-like isoform X1 [KO:K08054]
107688583  calnexin-like [KO:K08054]
107671642  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107704886  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107696263  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107694360  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107661453  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
107702625  calreticulin-like [KO:K08057]
107696693  calreticulin-like [KO:K08057]
107704500  calreticulin-like [KO:K08057]
107699587  calreticulin-like [KO:K08057]
107657889  calreticulin-like [KO:K08057]
107687912  calreticulin-like [KO:K08057]
107658234  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
107678845  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
107668846  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
107665908  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107697158  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
107688186  man1c1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [KO:K01230] [EC:3.2.1.113]
107690671  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107661470  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107681241  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107692283  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
107662004  vesicular integral-membrane protein VIP36-like [KO:K10082]
107664785  vesicular integral-membrane protein VIP36-like isoform X1 [KO:K10082]
107701961  protein ERGIC-53-like [KO:K10080]
107662211  protein ERGIC-53-like [KO:K10080]
107703926  preb; prolactin regulatory element-binding protein isoform X1 [KO:K14003]
107689009  prolactin regulatory element-binding protein-like [KO:K14003]
107657201  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107673926  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107659671  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107668454  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
107668793  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
107691189  protein SEC13 homolog [KO:K14004]
107657312  protein SEC13 homolog [KO:K14004]
107688052  protein transport protein Sec31A-like [KO:K14005]
107659695  protein transport protein Sec31A-like isoform X1 [KO:K14005]
107683464  protein transport protein Sec31A-like isoform X1 [KO:K14005]
107702588  protein transport protein Sec31A-like isoform X1 [KO:K14005]
107678217  protein transport protein Sec23A [KO:K14006]
107689296  protein transport protein Sec23A [KO:K14006]
107659946  protein transport protein Sec23A-like [KO:K14006]
107693184  protein transport protein Sec23A-like [KO:K14006]
107696053  protein transport protein Sec24C-like [KO:K14007]
107691847  sec24d; protein transport protein Sec24D isoform X1 [KO:K14007]
107690934  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107657199  protein transport protein Sec24A-like [KO:K14007]
107662171  protein transport protein Sec24B-like isoform X1 [KO:K14007]
107704651  protein transport protein Sec24B-like isoform X1 [KO:K14007]
107668452  protein transport protein Sec24A-like [KO:K14007]
107654639  protein transport protein Sec24C-like [KO:K14007]
107659096  protein transport protein Sec24D-like [KO:K14007]
107684100  protein transport protein Sec24C-like isoform X1 [KO:K14007]
107663813  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107683622  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107678683  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
107655477  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
107657818  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107666987  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
107697010  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
107700180  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107676607  LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
107692276  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107661556  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
107669525  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
107701207  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
107695410  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
107686698  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
107696113  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107693218  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
107664668  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
107678545  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
107693134  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107679999  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
107661156  ero1b; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
107667395  protein OS-9-like isoform X1 [KO:K10088]
107673576  protein OS-9-like isoform X1 [KO:K10088]
107654972  endoplasmic reticulum lectin 1-like isoform X1 [KO:K14008]
107679899  endoplasmic reticulum lectin 1-like isoform X1 [KO:K14008]
107698707  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
107690869  translocon-associated protein subunit alpha-like [KO:K13249]
107656630  translocon-associated protein subunit beta [KO:K13250]
107667782  translocon-associated protein subunit beta-like [KO:K13250]
107675610  translocon-associated protein subunit gamma [KO:K13251]
107671067  translocon-associated protein subunit gamma-like [KO:K13251]
107671948  translocon-associated protein subunit delta-like [KO:K04571]
107657031  translocon-associated protein subunit delta-like [KO:K04571]
107674338  B-cell receptor-associated protein 31-like [KO:K14009]
107653425  B-cell receptor-associated protein 31-like [KO:K14009]
107656677  translocating chain-associated membrane protein 1-like [KO:K14010]
107657822  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107693805  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
107684897  translocating chain-associated membrane protein 1-like 1 isoform X1 [KO:K14010]
107657695  derlin-1 [KO:K11519]
107699495  derlin-1-like [KO:K11519]
107691759  derl2; derlin-2 [KO:K13989]
107683227  derlin-2-like [KO:K13989]
107664304  derlin-2-like [KO:K13989]
107667536  derlin-2-like [KO:K13989]
107685417  UBX domain-containing protein 4-like [KO:K24348]
107676523  UBX domain-containing protein 1-like [KO:K24348]
107660275  UBX domain-containing protein 4-like [KO:K24348]
107680628  UBX domain-containing protein 1 [KO:K24348]
107697178  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
107699423  UBX domain-containing protein 6-like [KO:K14011]
107679838  UBX domain-containing protein 6-like [KO:K14011]
107665469  ubxn8; UBX domain-containing protein 8 [KO:K24351]
107672052  nsfl1c; NSFL1 cofactor p47 [KO:K14012]
107657023  NSFL1 cofactor p47-like [KO:K14012]
107677443  small VCP/p97-interacting protein-like [KO:K14014]
107695939  svip; small VCP/p97-interacting protein isoform X1 [KO:K14014]
107681079  transitional endoplasmic reticulum ATPase [KO:K13525]
107703743  transitional endoplasmic reticulum ATPase-like [KO:K13525]
107676650  transitional endoplasmic reticulum ATPase-like [KO:K13525]
107690944  nuclear protein localization protein 4 homolog [KO:K14015]
107684105  nuclear protein localization protein 4 homolog [KO:K14015]
107699633  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107670987  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
107662768  heat shock cognate 71 kDa protein-like [KO:K03283]
107675864  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
107668030  heat shock 70 kDa protein-like [KO:K03283]
107687002  heat shock 70 kDa protein [KO:K03283]
107691633  heat shock cognate 71 kDa protein-like [KO:K03283]
107693988  heat shock cognate 71 kDa protein [KO:K03283]
107692187  dnaJ homolog subfamily A member 1-like [KO:K09502]
107676129  dnaJ homolog subfamily A member 1-like [KO:K09502]
107686561  dnaJ homolog subfamily A member 2-like [KO:K09503]
107701235  dnaJ homolog subfamily A member 2-like [KO:K09503]
107662843  dnaJ homolog subfamily A member 2-like [KO:K09503]
107690732  dnaJ homolog subfamily A member 2-like [KO:K09503]
107694604  dnaJ homolog subfamily B member 1-like [KO:K09507]
107703757  dnaJ homolog subfamily B member 1-like [KO:K09507]
107661866  dnaJ homolog subfamily B member 1-like [KO:K09507]
107670512  dnaJ homolog subfamily B member 1-like [KO:K09507]
107668399  dnaJ homolog subfamily B member 2-like isoform X1 [KO:K09508]
107688744  dnaJ homolog subfamily B member 2-like isoform X1 [KO:K09508]
107688043  dnaJ homolog subfamily B member 12-like isoform X1 [KO:K09518]
107659693  dnaJ homolog subfamily B member 12-like isoform X1 [KO:K09518]
107673930  dnaJ homolog subfamily B member 12-like [KO:K09518]
107668821  dnaJ homolog subfamily B member 12-like [KO:K09518]
107672029  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107678568  dnaJ homolog subfamily C member 5-like [KO:K09525]
107663636  dnaJ homolog subfamily C member 5-like [KO:K09525]
107668106  dnaJ homolog subfamily C member 5-like [KO:K09525]
107692486  dnaJ homolog subfamily C member 5-like [KO:K09525]
107675096  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107676252  dnajc5g; dnaJ homolog subfamily C member 5G isoform X1 [KO:K09525]
107656153  dnaJ homolog subfamily C member 5-like [KO:K09525]
107653690  dnaJ homolog subfamily C member 5-like [KO:K09525]
107657050  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
107704346  heat shock protein HSP 90-alpha 1-like [KO:K04079]
107704347  heat shock protein HSP 90-alpha 1-like [KO:K04079]
107704376  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
107704377  heat shock protein HSP 90-alpha 1 [KO:K04079]
107704054  heat shock protein HSP 90-beta-like [KO:K04079]
107669433  heat shock protein HSP 90-beta [KO:K04079]
107703472  hspa4l; heat shock 70 kDa protein 4L isoform X1 [KO:K09485]
107664079  BAG family molecular chaperone regulator 1-like [KO:K09555]
107686087  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
107681030  bag2; BAG family molecular chaperone regulator 2 isoform X1 [KO:K09556]
107659576  hspbp1; hsp70-binding protein 1 [KO:K09562]
107653465  hsp70-binding protein 1-like [KO:K09562]
107667665  alpha-crystallin A chain-like [KO:K09541]
107654264  alpha-crystallin A chain isoform X1 [KO:K09541]
107701412  alpha-crystallin B chain-like [KO:K09542]
107701566  alpha-crystallin A chain-like [KO:K09542]
107691740  alpha-crystallin B chain-like [KO:K09542]
107663778  alpha-crystallin B chain-like [KO:K09542]
107659907  alpha-crystallin B chain-like [KO:K09542]
107675875  alpha-crystallin B chain-like [KO:K09542]
107699783  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
107694882  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
107661955  phospholipase A-2-activating protein-like isoform X1 [KO:K14018]
107660709  phospholipase A-2-activating protein-like [KO:K14018]
107702626  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107660841  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107704496  UV excision repair protein RAD23 homolog B-like [KO:K10839]
107675389  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107694545  UV excision repair protein RAD23 homolog B-like isoform X1 [KO:K10839]
107694827  UV excision repair protein RAD23 homolog A-like [KO:K10839]
107688227  ubiquilin-4-like [KO:K04523]
107671435  ubqln4; ubiquilin-4 [KO:K04523]
107688325  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like isoform X1 [KO:K01456] [EC:3.5.1.52]
107696895  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
107683100  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
107677681  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
107687604  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
107695775  LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
107681967  ubiquitin conjugation factor E4 B-like isoform X1 [KO:K10597] [EC:2.3.2.27]
107671339  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
107655313  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107704056  eukaryotic translation initiation factor 2 subunit 1-like isoform X1 [KO:K03237]
107657741  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107669459  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
107677604  transcription factor NF-E2 45 kDa subunit-like isoform X1 [KO:K05638]
107657385  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
107660051  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
107697927  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
107664150  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
107671308  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
107656792  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107662376  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
107666712  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
107676728  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
107683613  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
107681268  uncharacterized protein LOC107681268 [KO:K04452]
107671740  apoptosis regulator Bcl-2-like [KO:K02161]
107677290  apoptosis regulator Bcl-2-like [KO:K02161]
107697692  apoptosis regulator Bcl-2-like [KO:K02161]
107696152  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
107698395  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
107703634  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
107693772  cyclic AMP-dependent transcription factor ATF-6 beta-like [KO:K09049]
107661056  wolframin-like [KO:K14020]
107666128  wolframin-like [KO:K14020]
107692704  wolframin-like [KO:K14020]
107672278  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
107694940  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
107671355  mbtps2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
107653472  probable serine/threonine-protein kinase ireA isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107664531  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107692655  ern2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107659569  serine/threonine-protein kinase ppk4-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107702527  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107701911  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
107697985  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
107681247  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107684359  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
107654304  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107690679  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
107653159  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
107660504  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107700717  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107704978  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
107692141  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
107676852  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
107701924  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107662288  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107673914  mitogen-activated protein kinase 8A isoform X1 [KO:K04440] [EC:2.7.11.24]
107667593  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107673832  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107693656  mitogen-activated protein kinase 8B-like [KO:K04440] [EC:2.7.11.24]
107668799  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107653969  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107686821  apoptosis regulator BAX-like [KO:K02159]
107674732  apoptosis regulator BAX-like [KO:K02159]
107679719  apoptosis regulator BAX-like [KO:K02159]
107658432  apoptosis regulator BAX-like [KO:K02159]
107693506  apoptosis regulator BAX-like [KO:K02159]
107654525  apoptosis regulator BAX-like [KO:K02159]
107658414  apoptosis regulator R1-like [KO:K02159]
107658416  uncharacterized protein LOC107658416 [KO:K02159]
107664433  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107659327  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107679188  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107657473  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107655377  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
107676389  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107693804  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107703864  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107662629  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
107679193  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107659324  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107659328  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655374  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655376  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655378  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107676365  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107655329  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
107686038  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
107664076  E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
107680311  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
107660519  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
107664234  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
107697915  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
107686891  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107692306  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
107664516  ube2g1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
107678222  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
107660015  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
107664765  syvn1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
107662029  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
107694772  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
107694020  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
107675887  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
107687244  E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
107662252  selenoprotein S-like isoform X1 [KO:K14025]
107691972  selenoprotein S-like isoform X1 [KO:K14025]
107665378  protein sel-1 homolog 1-like [KO:K14026]
107659197  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
107686272  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
107672290  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform X1 [KO:K14027]
107659867  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107679970  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
107687053  stub1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
107667094  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
107698105  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107680290  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107667076  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107678444  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
107697612  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107677353  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107677381  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107666513  ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
107695533  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107671130  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107654054  ubiquitin-conjugating enzyme E2 D4-like isoform X1 [KO:K06689] [EC:2.3.2.23]
107660164  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
107663272  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
107669573  E3 ubiquitin-protein ligase parkin-like isoform X1 [KO:K04556] [EC:2.3.2.31]
107696378  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
107695112  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
107672143  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
107656141  cullin-1-like [KO:K03347]
107663526  cullin-1 [KO:K03347]
107686696  cullin-1-like [KO:K03347]
107695409  cullin-1-like [KO:K03347]
107692975  S-phase kinase-associated protein 1 [KO:K03094]
107661767  skp1; S-phase kinase-associated protein 1 [KO:K03094]
107654389  F-box only protein 2-like [KO:K10099]
107654414  F-box only protein 2-like [KO:K10099]
107671949  F-box only protein 6-like isoform X1 [KO:K10100]
107657006  F-box only protein 6-like [KO:K10100]
107657062  F-box only protein 44-like isoform X1 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
sanh00510  N-Glycan biosynthesis
sanh03050  Proteasome
sanh03060  Protein export
sanh04210  Apoptosis
KO pathway
ko04141   
LinkDB

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