KEGG   PATHWAY: sclv04141
Entry
sclv04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Styela clava (leathery sea squirt)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sclv04141  Protein processing in endoplasmic reticulum
sclv04141

Other DBs
GO: 0030433 0034976
Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120339550  protein transport protein Sec61 subunit alpha [KO:K10956]
120339745  protein transport protein Sec61 subunit alpha [KO:K10956]
120329540  protein transport protein Sec61 subunit beta-like [KO:K09481]
120330158  protein transport protein Sec61 subunit beta-like [KO:K09481]
120345922  translocation protein SEC62-like isoform X1 [KO:K12275]
120325511  translocation protein SEC63 homolog [KO:K09540]
120347547  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like isoform X1 [KO:K12666]
120347818  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
120332187  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
120332189  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1-like [KO:K12668]
120333698  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
120335564  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
120326403  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
120335411  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
120342775  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
120341053  tumor suppressor candidate 3-like [KO:K19478]
120341318  magnesium transporter protein 1-like [KO:K19478]
120347811  oligosaccharyltransferase complex subunit ostc-B-like [KO:K26501]
120339076  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
120339855  early endosome antigen 1-like isoform X1 [KO:K14000]
120339936  nucleotide exchange factor SIL1-like [KO:K14001]
120335648  hypoxia up-regulated protein 1-like isoform X1 [KO:K09486]
120344158  endoplasmic reticulum chaperone BiP-like isoform X1 [KO:K09490] [EC:3.6.4.10]
120344981  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
120343946  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 11-like [KO:K09517]
120344165  uncharacterized protein F54F2.9-like [KO:K09521]
120328020  dnaJ homolog subfamily C member 3-like [KO:K09523]
120342072  dnaJ homolog subfamily C member 10-like isoform X1 [KO:K09530] [EC:1.8.4.-]
120328014  endoplasmin-like [KO:K09487]
120326139  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
120335368  glucosidase 2 subunit beta-like [KO:K08288]
120347799  uncharacterized protein LOC120347799 [KO:K08288]
120346026  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
120347417  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
120340314  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
120344397  LOW QUALITY PROTEIN: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
120335347  LOW QUALITY PROTEIN: vesicular integral-membrane protein VIP36-like [KO:K10082]
120325427  vesicular integral-membrane protein VIP36-like [KO:K10082]
120330039  protein ERGIC-53-like [KO:K10080]
120335760  prolactin regulatory element-binding protein-like [KO:K14003]
120347551  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
120327292  protein SEC13 homolog [KO:K14004]
120347126  protein transport protein Sec31A-like isoform X1 [KO:K14005]
120335700  protein transport protein Sec23A-like [KO:K14006]
120329456  protein transport protein Sec24C-like [KO:K14007]
120346915  protein transport protein Sec24A-like isoform X1 [KO:K14007]
120327819  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
120328149  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
120341173  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
120344159  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
120341021  protein disulfide-isomerase 2-like [KO:K09580] [EC:5.3.4.1]
120333355  protein disulfide-isomerase 2-like isoform X1 [KO:K09580] [EC:5.3.4.1]
120333955  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
120331818  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
120334050  endoplasmic reticulum resident protein 29-like [KO:K09586]
120331704  thioredoxin domain-containing protein 5-like isoform X1 [KO:K13984] [EC:5.3.4.1]
120341795  uncharacterized protein LOC120341795 [KO:K13984] [EC:5.3.4.1]
120335965  ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
120347469  protein OS-9-like isoform X1 [KO:K10088]
120325744  endoplasmic reticulum lectin 1-like [KO:K14008]
120328853  translocon-associated protein subunit alpha-like [KO:K13249]
120334441  translocon-associated protein subunit beta-like [KO:K13250]
120328826  translocon-associated protein subunit gamma-like [KO:K13251]
120330828  translocon-associated protein subunit delta-like [KO:K04571]
120339211  B-cell receptor-associated protein 31-like [KO:K14009]
120330825  translocating chain-associated membrane protein 1-like isoform X1 [KO:K14010]
120330894  derlin-1-like [KO:K11519]
120334052  derlin-2-like [KO:K13989]
120336353  UBX domain-containing protein 4-like [KO:K24348]
120341002  UBX domain-containing protein 1-like [KO:K24348]
120344599  LOW QUALITY PROTEIN: UBX domain-containing protein 6-like [KO:K14011]
120338141  NSFL1 cofactor p47-like [KO:K14012]
120348503  NSFL1 cofactor p47-like [KO:K14012]
120340717  transitional endoplasmic reticulum ATPase [KO:K13525]
120333294  nuclear protein localization protein 4 homolog [KO:K14015]
120326075  ubiquitin recognition factor in ER-associated degradation protein 1-like [KO:K14016]
120343240  heat shock 70 kDa protein II-like [KO:K03283]
120343250  heat shock cognate 71 kDa protein-like [KO:K03283]
120343254  heat shock 70 kDa protein homolog [KO:K03283]
120343255  major heat shock 70 kDa protein Bbb-like [KO:K03283]
120343262  heat shock cognate 71 kDa protein-like [KO:K03283]
120343266  heat shock 70 kDa protein II-like [KO:K03283]
120343430  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343432  heat shock 70 kDa protein-like [KO:K03283]
120343433  heat shock 70 kDa protein II-like [KO:K03283]
120343458  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
120343471  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
120343534  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120343535  heat shock cognate 71 kDa protein-like [KO:K03283]
120343536  heat shock 70 kDa protein II-like [KO:K03283]
120343547  heat shock 70 kDa protein 1-like [KO:K03283]
120328696  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333404  heat shock 70 kDa protein-like [KO:K03283]
120333406  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120333407  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120341957  heat shock 70 kDa protein II-like [KO:K03283]
120341958  heat shock 70 kDa protein II-like [KO:K03283]
120341968  heat shock 70 kDa protein II-like [KO:K03283]
120341969  heat shock cognate 71 kDa protein-like [KO:K03283]
120341970  heat shock 70 kDa protein II-like [KO:K03283]
120341971  heat shock cognate 71 kDa protein-like [KO:K03283]
120341972  heat shock 70 kDa protein II-like [KO:K03283]
120342073  heat shock 70 kDa protein II-like [KO:K03283]
120342225  heat shock 70 kDa protein II-like [KO:K03283]
120342233  heat shock 70 kDa protein II-like isoform X1 [KO:K03283]
120342234  heat shock 70 kDa protein-like [KO:K03283]
120342333  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120342390  heat shock cognate 71 kDa protein-like [KO:K03283]
120342403  heat shock cognate 71 kDa protein [KO:K03283]
120342404  heat shock 70 kDa protein 1B-like [KO:K03283]
120342414  heat shock 70 kDa protein cognate 4-like [KO:K03283]
120334019  heat shock 70 kDa protein 1-like [KO:K03283]
120334030  heat shock 70 kDa protein II-like [KO:K03283]
120342918  heat shock 70 kDa protein II-like [KO:K03283]
120342969  heat shock 70 kDa protein II-like [KO:K03283]
120343013  heat shock 70 kDa protein 1A-like [KO:K03283]
120343030  heat shock 70 kDa protein-like [KO:K03283]
120343032  heat shock 70 kDa protein-like [KO:K03283]
120343056  uncharacterized protein LOC120343056 [KO:K03283]
120343059  putative heat shock 70 kDa protein 7 [KO:K03283]
120343064  heat shock 70 kDa protein-like [KO:K03283]
120343068  heat shock 70 kDa protein II-like [KO:K03283]
120343069  heat shock cognate 71 kDa protein-like [KO:K03283]
120343089  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
120343091  chromosome partition protein Smc-like [KO:K03283]
120343098  heat shock 70 kDa protein II-like [KO:K03283]
120343099  heat shock 70 kDa protein 4L-like [KO:K03283]
120343104  heat shock 70 kDa protein 1-like [KO:K03283]
120343109  uncharacterized protein LOC120343109 [KO:K03283]
120343132  heat shock 70 kDa protein II-like [KO:K03283]
120348505  dnaJ homolog subfamily A member 1-like [KO:K09502]
120339673  dnaJ homolog subfamily B member 1-like [KO:K09507]
120347294  dnaJ homolog subfamily B member 12-like [KO:K09518]
120330714  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
120330874  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
120335586  heat shock protein HSP 90-beta-like [KO:K04079]
120335974  BAG family molecular chaperone regulator 1-like [KO:K09555]
120342729  hsp70-binding protein 1-like [KO:K09562]
120328080  body wall muscle protein HR-29-like [KO:K09542]
120328142  body wall muscle protein HR-29-like [KO:K09542]
120327639  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
120336518  phospholipase A-2-activating protein-like [KO:K14018]
120336346  UV excision repair protein RAD23 homolog B-like [KO:K10839]
120339369  ubiquilin-1-like [KO:K04523]
120347473  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
120328255  ubiquitin conjugation factor E4 B-like isoform X1 [KO:K10597] [EC:2.3.2.27]
120338763  eukaryotic translation initiation factor 2-alpha kinase-like [KO:K08860] [EC:2.7.11.1]
120348078  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
120332842  cyclic AMP-dependent transcription factor ATF-5-like [KO:K04374]
120339284  wolframin-like [KO:K14020]
120331694  membrane-bound transcription factor site-1 protease-like isoform X1 [KO:K08653] [EC:3.4.21.112]
120326400  membrane-bound transcription factor site-2 protease-like isoform X1 [KO:K07765] [EC:3.4.24.85]
120325686  membrane-bound transcription factor site-2 protease-like isoform X1 [KO:K07765] [EC:3.4.24.85]
120342950  uncharacterized protein LOC120342950 isoform X1 [KO:K09027]
120326393  uncharacterized protein LOC120326393 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120334870  uncharacterized protein LOC120334870 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120335058  uncharacterized protein LOC120335058 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120327646  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120336190  sensor for unfolded proteins in the ER ire1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120344607  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120328111  serine/threonine-protein kinase/endoribonuclease ire-1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120345055  serine/threonine-protein kinase/endoribonuclease IRE1-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120344497  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
120330741  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
120346045  apoptosis regulator BAX-like [KO:K02159]
120332352  E3 ubiquitin-protein ligase MARCHF6-like [KO:K10661] [EC:2.3.2.27]
120330849  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
120329413  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
120330195  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
120339605  E3 ubiquitin-protein ligase synoviolin B-like [KO:K10601] [EC:2.3.2.27]
120339741  E3 ubiquitin-protein ligase synoviolin B-like [KO:K10601] [EC:2.3.2.27]
120336740  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
120326004  selenoprotein S-like [KO:K14025]
120340685  protein sel-1 homolog 1-like [KO:K14026]
120339637  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein [KO:K14027]
120346200  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
120344632  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
120334640  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
120347105  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
120347106  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
120347107  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
120341757  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
120342045  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
120342143  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
120341368  E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
120342351  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
120342615  LOW QUALITY PROTEIN: cullin-1-like [KO:K03347]
120347360  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
sclv00510  N-Glycan biosynthesis
sclv03050  Proteasome
sclv03060  Protein export
KO pathway
ko04141   
LinkDB

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