KEGG   PATHWAY: sgh04520
Entry
sgh04520                    Pathway                                
Name
Adherens junction - Sinocyclocheilus grahami (golden-line barbel)
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
sgh04520  Adherens junction
sgh04520

Other DBs
GO: 0005912
Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107551635  nectin-1-like isoform X1 [KO:K06081]
107548171  nectin-1-like isoform X1 [KO:K06081]
107561861  nectin-1-like [KO:K06081]
107576145  poliovirus receptor-like isoform X1 [KO:K06081]
107563312  nectin-1-like isoform X1 [KO:K06081]
107551971  nectin-1-like [KO:K06081]
107551686  nectin-2-like [KO:K06531]
107554349  nectin-2-like isoform X1 [KO:K06531]
107582119  nectin-2-like [KO:K06531]
107549846  nectin-2-like isoform X1 [KO:K06531]
107575456  nectin-3-like protein [KO:K06592]
107589265  nectin-3-like protein [KO:K06592]
107571834  nectin-3-like isoform X1 [KO:K06592]
107582654  nectin-3-like protein [KO:K06592]
107591719  nectin-3-like protein [KO:K06592]
107588797  nectin-3-like protein [KO:K06592]
107558436  nectin-4-like [KO:K06593]
107597911  nectin-4-like [KO:K06593]
107552666  nectin-4-like [KO:K06593]
107549793  nectin-4-like [KO:K06593]
107552787  partitioning defective 3 homolog [KO:K04237]
107563826  partitioning defective 3 homolog [KO:K04237]
107557790  partitioning defective 3 homolog [KO:K04237]
107593114  pard3; partitioning defective 3 homolog [KO:K04237]
107590469  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107558752  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
107593164  farp2; FERM, RhoGEF and pleckstrin domain-containing protein 2 [KO:K06082]
107552280  FERM, RhoGEF and pleckstrin domain-containing protein 2-like [KO:K06082]
107603155  cell division control protein 42 homolog isoform X1 [KO:K04393]
107552852  cell division control protein 42 homolog isoform X1 [KO:K04393]
107580157  cdc42 homolog [KO:K04393]
107587863  cell division control protein 42 homolog [KO:K04393]
107565734  cell division control protein 42 homolog [KO:K04393]
107582398  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107556616  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107596579  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107569188  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
107551172  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
107561353  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107571767  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
107601271  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107590454  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107579244  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
107575727  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107582691  proline-rich protein LAS17-like [KO:K23612]
107583945  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
107585203  wiskott-Aldrich syndrome protein-like [KO:K23612]
107598884  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107549977  wiskott-Aldrich syndrome protein-like isoform X1 [KO:K05747]
107549603  wiskott-Aldrich syndrome protein-like [KO:K05747]
107591865  wiskott-Aldrich syndrome protein-like [KO:K05747]
107550460  wiskott-Aldrich syndrome protein homolog [KO:K05747]
107596412  iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
107600473  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
107558622  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
107601402  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
107567237  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
107561850  LOW QUALITY PROTEIN: brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
107587957  brain-specific angiogenesis inhibitor 1-associated protein 2-like isoform X1 [KO:K05627]
107559019  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
107556997  wiskott-Aldrich syndrome protein family member 1-like [KO:K05753]
107564591  wiskott-Aldrich syndrome protein family member 1-like [KO:K05753]
107593571  wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
107591634  wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
107562726  wiskott-Aldrich syndrome protein family member 3-like isoform X1 [KO:K06083]
107584970  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
107591263  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
107560339  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
107562158  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
107581882  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
107549673  afadin-like [KO:K05702]
107603070  afadin-like [KO:K05702]
107552029  afadin-like [KO:K05702]
107597393  LIM domain only protein 7-like isoform X1 [KO:K06084]
107568843  lmo7; LIM domain only protein 7 isoform X1 [KO:K06084]
107567983  LIM domain only protein 7-like [KO:K06084]
107598770  LIM domain only protein 7-like [KO:K06084]
107564925  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
107562860  afadin- and alpha-actinin-binding protein-like [KO:K06085]
107573863  afadin- and alpha-actinin-binding protein-like [KO:K06085]
107594247  afadin- and alpha-actinin-binding protein B-like [KO:K06085]
107563523  afadin- and alpha-actinin-binding protein-like isoform X1 [KO:K06085]
107601782  sorbin and SH3 domain-containing protein 1-like [KO:K06086]
107563040  sorbin and SH3 domain-containing protein 1-like [KO:K06086]
107602958  alpha-actinin-1 isoform X1 [KO:K05699]
107558830  alpha-actinin-4-like isoform X1 [KO:K05699]
107553176  alpha-actinin-1-like [KO:K05699]
107570110  alpha-actinin-4 isoform X1 [KO:K05699]
107597760  LOW QUALITY PROTEIN: vinculin-like [KO:K05700]
107559309  vinculin-like [KO:K05700]
107595178  LOW QUALITY PROTEIN: vinculin-like [KO:K05700]
107601794  vinculin-like [KO:K05700]
107589322  tight junction protein ZO-1-like isoform X1 [KO:K05701]
107586031  tight junction protein ZO-1-like [KO:K05701]
107595074  tight junction protein ZO-1-like isoform X1 [KO:K05701]
107557981  tight junction protein ZO-1-like [KO:K05701]
107600334  B-cadherin-like [KO:K05689]
107574478  cadherin-4-like isoform X1 [KO:K05689]
107561456  B-cadherin-like isoform X1 [KO:K05689]
107561466  B-cadherin-like isoform X1 [KO:K05689]
107571929  cadherin-1-like [KO:K05689]
107600033  B-cadherin-like [KO:K05689]
107552243  catenin delta-1-like [KO:K05690]
107556814  ctnnd1; catenin delta-1 isoform X1 [KO:K05690]
107602383  ctnnb1; catenin beta-1 [KO:K02105]
107564884  catenin beta-1-like [KO:K02105]
107570993  catenin beta-1 isoform X1 [KO:K02105]
107592060  catenin beta-1-like [KO:K02105]
107594945  catenin alpha-1 [KO:K05691]
107558616  ctnna2; catenin alpha-2 [KO:K05691]
107594905  catenin alpha-1-like [KO:K05691]
107552348  catenin alpha-2-like [KO:K05691]
107573466  catenin alpha-2-like [KO:K05691]
107581721  actin, cytoplasmic 1-like [KO:K05692]
107590707  actin, cytoplasmic 1 isoform X1 [KO:K05692]
107564595  actin, cytoplasmic 1 [KO:K05692]
107591725  actin, cytoplasmic 1 [KO:K05692]
107579050  transforming protein RhoA-like [KO:K04513]
107549297  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107562777  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107569805  rho-related GTP-binding protein RhoA-D [KO:K04513]
107599000  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107603137  rho-related GTP-binding protein RhoA-A [KO:K04513]
107558917  rho-related GTP-binding protein RhoA-C [KO:K04513]
107571578  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107556503  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107591763  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107591788  rho-related GTP-binding protein RhoA-B [KO:K04513]
107594054  acp1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
107598777  low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
107578441  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
107570365  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
107578432  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
107566921  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
107549788  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
107566837  ptprb; receptor-type tyrosine-protein phosphatase beta [KO:K05694] [EC:3.1.3.48]
107562139  receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
107575178  receptor-type tyrosine-protein phosphatase beta-like [KO:K05694] [EC:3.1.3.48]
107551707  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
107554866  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
107564386  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
107582347  ptprf; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
107594510  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
107556311  tyrosine-protein phosphatase non-receptor type 1-like [KO:K05696] [EC:3.1.3.48]
107552793  tyrosine-protein phosphatase non-receptor type 6-like [KO:K05697] [EC:3.1.3.48]
107587794  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
107553844  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
107549291  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
107590988  receptor-type tyrosine-protein phosphatase eta-like isoform X1 [KO:K05698] [EC:3.1.3.48]
107554646  receptor-type tyrosine-protein phosphatase eta-like [KO:K05698] [EC:3.1.3.48]
107572031  casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
107572060  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
107577984  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107589174  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107589440  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107600363  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107552798  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107561443  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107557527  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107559708  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
107587871  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
107576382  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107595585  casein kinase II subunit beta [KO:K03115]
107584313  casein kinase II subunit beta [KO:K03115]
107603263  transcription factor 7-like [KO:K02620]
107557295  transcription factor 7-like 2 isoform X1 [KO:K02620]
107558109  transcription factor 7-like 1-A [KO:K04490]
107563849  transcription factor 7-like 1-B [KO:K04490]
107556226  transcription factor 7-like 1-B [KO:K04490]
107602061  transcription factor 7-like 1-A [KO:K04490]
107581563  transcription factor 7-like 2 [KO:K04491]
107566231  transcription factor 7-like 2 isoform X1 [KO:K04491]
107583218  lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
107594427  lymphoid enhancer-binding factor 1-like [KO:K04492]
107583745  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107594738  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107596941  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107586934  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107591352  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107593049  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107558844  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
107574814  hepatocyte growth factor receptor-like isoform X1 [KO:K05099] [EC:2.7.10.1]
107574004  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
107554803  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
107566457  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
107599721  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
107560555  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107573419  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
107559452  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
107559453  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
107588986  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
107553171  fibroblast growth factor receptor 1-A [KO:K04362] [EC:2.7.10.1]
107602069  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
107603170  tyrosine-protein kinase Fer-like [KO:K08889] [EC:2.7.10.2]
107564044  tyrosine-protein kinase Fer-like [KO:K08889] [EC:2.7.10.2]
107564973  tyrosine-protein kinase fyna-like [KO:K05703] [EC:2.7.10.2]
107548254  tyrosine-protein kinase fynb [KO:K05703] [EC:2.7.10.2]
107565451  tyrosine-protein kinase fynb-like [KO:K05703] [EC:2.7.10.2]
107583469  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
107558136  tyrosine-protein kinase yes-like [KO:K05705] [EC:2.7.10.2]
107584194  tyrosine-protein kinase yes [KO:K05705] [EC:2.7.10.2]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107558792  protein snail homolog Sna-like [KO:K05706]
107599746  zinc finger protein SNAI2-like [KO:K05706]
107554695  zinc finger protein SNAI2-like [KO:K05706]
107599821  protein snail homolog Sna-like [KO:K05707]
107549169  protein snail homolog Sna-like [KO:K05707]
107581900  protein snail homolog Sna-like [KO:K05707]
107566165  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107585257  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107589809  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107561948  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107596078  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107555932  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107551196  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107569139  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107600517  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107583760  mothers against decapentaplegic homolog 3-like [KO:K23605]
107553101  mothers against decapentaplegic homolog 3 [KO:K23605]
107563442  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107570722  mothers against decapentaplegic homolog 4-like [KO:K04501]
107594567  mothers against decapentaplegic homolog 4-like [KO:K04501]
107597968  mothers against decapentaplegic homolog 4-like [KO:K04501]
107563920  mothers against decapentaplegic homolog 4-like [KO:K04501]
107549232  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107559658  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
107557579  mothers against decapentaplegic homolog 4-like [KO:K04501]
107550085  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
107566050  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107602282  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107553628  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107554018  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107566670  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
107584175  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107583302  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107601576  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
107597461  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
107601937  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
107582859  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
107588115  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
107592924  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
107590844  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
107551739  cadherin-5-like [KO:K06533]
107564636  cadherin-5-like isoform X1 [KO:K06533]
107555935  protein HEG-like isoform X1 [KO:K24472]
107591966  krev interaction trapped protein 1 isoform X1 [KO:K17705]
107592919  krev interaction trapped protein 1-like [KO:K17705]
107589047  cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
107561942  cerebral cavernous malformations protein 2 homolog isoform X1 [KO:K26416]
107591423  programmed cell death protein 10-like [KO:K18269]
107557361  programmed cell death protein 10-B [KO:K18269]
107600227  programmed cell death protein 10-A [KO:K18269]
107561067  programmed cell death protein 10-A-like [KO:K18269]
107581717  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
107602340  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
107583299  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
107591759  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
107560426  ras-related protein Rap-1A-like [KO:K04353]
107594522  ras-related protein Rap-1A [KO:K04353]
107556321  ras-related protein Rap-1A-like [KO:K04353]
107591033  uncharacterized protein LOC107591033 [KO:K04353]
107557907  ras-related protein Rap-1A-like [KO:K04353]
107553881  rap1b; ras-related protein Rap-1b [KO:K07836]
107549479  ras-interacting protein 1-like [KO:K26417]
107598383  ras-interacting protein 1-like isoform X1 [KO:K26417]
107590699  ras-associating and dilute domain-containing protein isoform X1 [KO:K26418]
107552106  ras-associating and dilute domain-containing protein-like [KO:K26418]
107564693  ras-associating and dilute domain-containing protein-like isoform X1 [KO:K26418]
107562037  ras-associating and dilute domain-containing protein-like [KO:K26418]
107595647  ras-associating and dilute domain-containing protein-like [KO:K26418]
107594651  arhgap29; rho GTPase-activating protein 29 isoform X1 [KO:K20644]
107558540  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
107590264  rho GTPase-activating protein 29-like isoform X1 [KO:K20644]
107564532  rho GTPase-activating protein 29 isoform X1 [KO:K20644]
107593752  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107567877  rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
107602474  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
107555625  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
107588686  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
107585483  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
107552143  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
107563425  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
107567947  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
107553045  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107568547  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
107554405  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
107550934  myosin regulatory light chain 2, atrial isoform-like [KO:K12754]
107569439  myosin regulatory light polypeptide 9 [KO:K12755]
107554878  myosin regulatory light polypeptide 9-like [KO:K12755]
107582309  myosin regulatory light polypeptide 9-like [KO:K12755]
107577538  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
107588876  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
107556619  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
107559936  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
107584242  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
107601174  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
107554126  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107582990  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107572535  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
107571443  myosin regulatory light chain 2, skeletal muscle isoform type 2 [KO:K12758]
Reference
PMID:15001769
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
DOI:10.1126/science.1094291
Reference
PMID:10204118
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
DOI:10.1210/edrv.20.2.0362
Reference
PMID:10959047
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
DOI:10.1016/S0959-8049(00)00158-1
Reference
PMID:15489912
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
DOI:10.1038/sj.onc.1208161
Reference
PMID:11171368
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
PMID:11984870
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
DOI:10.1002/dvdy.10087
Reference
PMID:12640114
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
DOI:10.1128/MCB.23.7.2287-2297.2003
Reference
PMID:14623871
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
DOI:10.1083/jcb.200308162
Reference
PMID:11703922
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
DOI:10.1016/S1534-5807(01)00017-X
Reference
PMID:12665527
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
DOI:10.1074/jbc.M211304200
Reference
PMID:10890911
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
DOI:10.1073/pnas.150152697
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Related
pathway
sgh04010  MAPK signaling pathway
sgh04060  Cytokine-cytokine receptor interaction
sgh04310  Wnt signaling pathway
sgh04350  TGF-beta signaling pathway
sgh04530  Tight junction
sgh04810  Regulation of actin cytoskeleton
KO pathway
ko04520   
LinkDB

DBGET integrated database retrieval system