KEGG   PATHWAY: spu04146
Entry
spu04146                    Pathway                                
Name
Peroxisome - Strongylocentrotus purpuratus (purple sea urchin)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
spu04146  Peroxisome
spu04146

Other DBs
GO: 0005777
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
577593  peroxisomal membrane protein PEX16 [KO:K13335]
575398  peroxisomal biogenesis factor 3 [KO:K13336]
764026  peroxisomal biogenesis factor 3 [KO:K13336]
753366  peroxisomal biogenesis factor 19 [KO:K13337]
115918437  peroxisomal biogenesis factor 19-like [KO:K13337]
583732  ATP-binding cassette sub-family D member 3 isoform X1 [KO:K05677] [EC:7.6.2.4]
105445741  ATP-binding cassette sub-family D member 3-like isoform X1 [KO:K05677] [EC:7.6.2.4]
592476  peroxisome biogenesis factor 1 [KO:K13338]
580015  peroxisome assembly factor 2 [KO:K13339]
100893962  peroxisome assembly protein 26 [KO:K13340]
586615  peroxisomal targeting signal 2 receptor [KO:K13341]
100891185  peroxisomal targeting signal 1 receptor isoform X1 [KO:K13342]
593931  peroxisomal membrane protein PEX14 [KO:K13343]
115924540  peroxisomal membrane protein PEX14-like [KO:K13343]
594428  peroxisomal membrane protein PEX13 [KO:K13344]
100891192  peroxisomal membrane protein PEX13 [KO:K13344]
583111  peroxisome assembly protein 12 [KO:K13345]
115924476  peroxisome biogenesis factor 10-like [KO:K13346]
100891311  peroxisome biogenesis factor 10 [KO:K13346]
582970  peroxisome biogenesis factor 2 [KO:K06664]
584245  peroxisomal membrane protein 2 [KO:K13347]
588887  protein Mpv17 [KO:K13348]
105438674  mpv17-like protein 2 isoform X1 [KO:K13348]
100893960  protein Mpv17 [KO:K13348]
115918392  protein Mpv17-like [KO:K13348]
115918393  protein Mpv17-like [KO:K13348]
583667  mpv17-like protein [KO:K13349]
594649  peroxisomal membrane protein 4 [KO:K13350]
582629  peroxisomal membrane protein 11B [KO:K13352]
576910  peroxisomal membrane protein 11A [KO:K13352]
582076  peroxisomal membrane protein 11C [KO:K13353]
578063  peroxisomal membrane protein PMP34 [KO:K13354]
586415  2-hydroxyacyl-CoA lyase 1 [KO:K12261] [EC:4.1.2.63]
589843  alpha-methylacyl-CoA racemase isoform X1 [KO:K01796] [EC:5.1.99.4]
579037  phytanoyl-CoA dioxygenase, peroxisomal [KO:K00477] [EC:1.14.11.18]
115919089  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
580903  peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
578168  peroxisomal acyl-coenzyme A oxidase 1 isoform X3 [KO:K00232] [EC:1.3.3.6]
580036  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
580963  peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
581580  peroxisomal multifunctional enzyme type 2 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
115918401  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
576367  LOW QUALITY PROTEIN: non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
100893445  non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
115918990  non-specific lipid-transfer protein-like [KO:K08764] [EC:2.3.1.176]
100892177  bile acid-CoA:amino acid N-acyltransferase isoform X2 [KO:K00659] [EC:2.3.1.65 3.1.2.2]
115926355  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
588204  peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
753669  peroxisomal bifunctional enzyme-like isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
587557  3-ketoacyl-CoA thiolase A, peroxisomal [KO:K07513] [EC:2.3.1.16]
115918115  3-ketoacyl-CoA thiolase A, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
590477  peroxisomal 2,4-dienoyl-CoA reductase isoform X1 [KO:K13237] [EC:1.3.1.124]
578800  enoyl CoA hydratase 1, peroxisomal-like [KO:K12663] [EC:5.3.3.21]
115918238  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
589309  LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
753304  ATP-binding cassette sub-family D member 2 [KO:K05676] [EC:7.6.2.4]
590006  ATP-binding cassette sub-family D member 4 [KO:K05678] [EC:7.6.2.8]
575511  very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
579013  very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
590937  long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
581020  long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
582198  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
574703  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
575831  long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
587387  long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
753112  long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
115921603  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
594520  long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
753057  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
579703  peroxisomal trans-2-enoyl-CoA reductase [KO:K07753] [EC:1.3.1.38]
574788  enoyl-CoA delta isomerase 2, mitochondrial [KO:K13239] [EC:5.3.3.8]
115918391  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
575580  enoyl-CoA delta isomerase 2, mitochondrial [KO:K13239] [EC:5.3.3.8]
105446438  peroxisomal coenzyme A diphosphatase NUDT7-like [KO:K17879] [EC:3.6.1.77]
115920738  peroxisomal NADH pyrophosphatase NUDT12-like [KO:K03426] [EC:3.6.1.22]
100889641  peroxisomal NADH pyrophosphatase NUDT12 [KO:K03426] [EC:3.6.1.22]
581737  nucleoside diphosphate-linked moiety X motif 13 [KO:K03426] [EC:3.6.1.22]
756379  nucleoside diphosphate-linked moiety X motif 19 [KO:K13355] [EC:3.6.1.77]
589369  acyl-coenzyme A thioesterase 8 [KO:K11992] [EC:3.1.2.27]
593866  carnitine O-acetyltransferase [KO:K00624] [EC:2.3.1.7]
585404  peroxisomal carnitine O-octanoyltransferase [KO:K05940] [EC:2.3.1.137]
580492  peroxisomal carnitine O-octanoyltransferase [KO:K05940] [EC:2.3.1.137]
754019  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
753309  LOW QUALITY PROTEIN: malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
590838  dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
585499  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1 [KO:K00803] [EC:2.5.1.26]
584999  LOW QUALITY PROTEIN: fatty acyl-CoA reductase 1 [KO:K13356] [EC:1.2.1.84]
115925419  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
589139  mevalonate kinase-like [KO:K00869] [EC:2.7.1.36]
100890384  phosphomevalonate kinase [KO:K13273] [EC:2.7.4.2]
115922376  LOW QUALITY PROTEIN: phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
575497  serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
576222  LOW QUALITY PROTEIN: D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
590228  D-aspartate oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
582896  D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
590206  D-aspartate oxidase [KO:K00272] [EC:1.4.3.1]
581147  isocitrate dehydrogenase [NADP] cytoplasmic isoform X1 [KO:K00031] [EC:1.1.1.42]
580429  isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
579633  peroxisomal N(1)-acetyl-spermine/spermidine oxidase [KO:K00308] [EC:1.5.3.13]
593351  peroxisomal N(1)-acetyl-spermine/spermidine oxidase [KO:K00308] [EC:1.5.3.13]
591772  LOW QUALITY PROTEIN: peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
592753  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
575397  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
578086  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
593952  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
756856  hydroxymethylglutaryl-CoA lyase, mitochondrial [KO:K01640] [EC:4.1.3.4]
594782  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
585244  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
586372  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
115923842  peroxisomal (S)-2-hydroxy-acid oxidase GLO5-like [KO:K11517] [EC:1.1.3.15]
115923843  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
105439393  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
115924135  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
100890229  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
584548  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
590153  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
578272  hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
575110  hydroxyacid oxidase 1 isoform X1 [KO:K11517] [EC:1.1.3.15]
583653  LOW QUALITY PROTEIN: hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
105438524  hydroxyacid oxidase 2-like [KO:K11517] [EC:1.1.3.15]
752067  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
115926388  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
115926389  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
115918826  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
592375  LOW QUALITY PROTEIN: hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
105446915  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
584105  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
589061  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
591284  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
590358  hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
548621  catalase [KO:K03781] [EC:1.11.1.6]
100888042  catalase-like [KO:K03781] [EC:1.11.1.6]
115929510  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
579361  superoxide dismutase [Cu-Zn] isoform X1 [KO:K04565] [EC:1.15.1.1]
105444373  superoxide dismutase [Cu-Zn]-like isoform X1 [KO:K04565] [EC:1.15.1.1]
580111  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
586977  uncharacterized protein LOC586977 [KO:K04564] [EC:1.15.1.1]
581408  peroxiredoxin [KO:K13279] [EC:1.11.1.24]
590472  EH1; soluble epoxide hydrolase-like protein 1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
752510  eh2; soluble epoxide hydrolase-like protein 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
576712  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
588814  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115918813  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
585597  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
756453  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
764565  dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
spu00071  Fatty acid degradation
spu00230  Purine metabolism
spu00564  Glycerophospholipid metabolism
spu00565  Ether lipid metabolism
spu00830  Retinol metabolism
spu00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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