KEGG   PATHWAY: spu00230
Entry
spu00230                    Pathway                                
Name
Purine metabolism - Strongylocentrotus purpuratus (purple sea urchin)
Class
Metabolism; Nucleotide metabolism
Pathway map
spu00230  Purine metabolism
spu00230

Module
spu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:spu00230]
spu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:spu00230]
spu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:spu00230]
spu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:spu00230]
spu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:spu00230]
spu_M00546  Purine degradation, xanthine => urea [PATH:spu00230]
spu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:spu00230]
spu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:spu00230]
Other DBs
GO: 0006163 0042278
Organism
Strongylocentrotus purpuratus (purple sea urchin) [GN:spu]
Gene
756760  ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
115926883  ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
580253  ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
575075  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
763027  phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
585120  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
582049  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
115922210  amidophosphoribosyltransferase-like [KO:K00764] [EC:2.4.2.14]
580766  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
576564  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
575874  multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
593658  LOW QUALITY PROTEIN: adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
115917983  adenylosuccinate lyase-like [KO:K01756] [EC:4.3.2.2]
588680  bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
583890  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
593129  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
591937  uncharacterized protein LOC591937 isoform X2 [KO:K01081] [EC:3.1.3.5]
753743  5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
590091  5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
105442306  5'-nucleotidase-like [KO:K19970] [EC:3.1.3.5]
105441125  5'-nucleotidase-like isoform X1 [KO:K19970] [EC:3.1.3.5]
578392  purine nucleoside phosphorylase isoform X2 [KO:K03783] [EC:2.4.2.1]
585994  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
584371  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
752101  inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
115919533  inosine-5'-monophosphate dehydrogenase 1b-like isoform X1 [KO:K00088] [EC:1.1.1.205]
594617  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
590350  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
583346  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
105438171  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
588475  adenylate kinase 9 isoform X5 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
587808  soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
580175  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
115918638  ectonucleoside triphosphate diphosphohydrolase 4-like [KO:K12305] [EC:3.6.1.6]
576801  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
583647  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
576712  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
588814  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115918813  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
585597  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
756453  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
756973  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]-like [KO:K01518] [EC:3.6.1.17]
756144  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
578500  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
754448  GMP reductase 1-like isoform X1 [KO:K00364] [EC:1.7.1.7]
100888431  guanine deaminase [KO:K01487] [EC:3.5.4.3]
586667  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
581431  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
577596  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
594140  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100889292  HD domain-containing protein 2-like [KO:K07023] [EC:3.1.3.89]
579637  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
575180  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
582454  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
582776  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
115918037  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
574069  soluble adenylyl cyclase [KO:K11265] [EC:4.6.1.1]
100889569  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
579464  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
581605  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100890426  guanylate cyclase soluble subunit beta-2 isoform X1 [KO:K12319] [EC:4.6.1.2]
589539  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
115921429  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
115921433  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
576434  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
577615  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
582837  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
581820  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
100889870  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
100893963  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
373321  speract receptor precursor [KO:K01769] [EC:4.6.1.2]
756941  soluble guanylate cyclase 88E [KO:K01769] [EC:4.6.1.2]
576733  speract receptor [KO:K01769] [EC:4.6.1.2]
579339  speract receptor [KO:K01769] [EC:4.6.1.2]
100892109  soluble guanylate cyclase gcy-31-like [KO:K01769] [EC:4.6.1.2]
576425  PDE1; phosphodiesterase 1 [KO:K13755] [EC:3.1.4.17]
594283  cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
115922298  cGMP-dependent 3',5'-cyclic phosphodiesterase-like [KO:K18283] [EC:3.1.4.17]
589178  uncharacterized protein LOC589178 isoform X1 [KO:K19021] [EC:3.1.4.17]
753612  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
582146  pde5; sperm phosphodiesterase 5 [KO:K13763] [EC:3.1.4.35]
589578  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
590245  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
584165  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A-like [KO:K18438] [EC:3.1.4.17 3.1.4.35]
592747  probable 3',5'-cyclic phosphodiesterase pde-5 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105436467  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A-like [KO:K18438] [EC:3.1.4.17 3.1.4.35]
755676  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
577841  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
115919281  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like [KO:K13298] [EC:3.1.4.17 3.1.4.35]
582026  adenylosuccinate synthetase isozyme 1 A [KO:K01939] [EC:6.3.4.4]
587814  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
580959  adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
764505  adenosine kinase 1 [KO:K00856] [EC:2.7.1.20]
586781  LOW QUALITY PROTEIN: adenosine deaminase [KO:K01488] [EC:3.5.4.4]
580201  adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
100894124  adenosine deaminase AGSA [KO:K19572] [EC:3.5.4.4]
583310  adenosine deaminase AGSA [KO:K19572] [EC:3.5.4.4]
753458  adenylate kinase 2, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
592650  adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
576252  adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
584538  adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
594469  adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
583479  adenylate kinase 3-like [KO:K00944] [EC:2.7.4.10]
592174  cancer-related nucleoside-triphosphatase homolog [KO:K06928] [EC:3.6.1.15]
579858  venom phosphodiesterase 2 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
591232  venom phosphodiesterase 2 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100888624  uncharacterized protein LOC100888624 isoform X1 [KO:K13293] [EC:3.1.4.53]
579864  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
115922934  uncharacterized protein LOC115922934 isoform X1 [KO:K18436] [EC:3.1.4.53]
591166  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
100888568  bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
576349  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase [KO:K13811] [EC:2.7.7.4 2.7.1.25]
115918136  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase-like isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
588974  uricase [KO:K00365] [EC:1.7.3.3]
589020  transthyretin isoform X2 [KO:K07127] [EC:3.5.2.17]
752107  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
577905  allantoinase, mitochondrial isoform X1 [KO:K01466] [EC:3.5.2.5]
105446769  allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
576479  allantoicase [KO:K01477] [EC:3.5.3.4]
583434  uncharacterized protein LOC583434 isoform X1 [KO:K01427] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
spu00030  Pentose phosphate pathway
spu00220  Arginine biosynthesis
spu00250  Alanine, aspartate and glutamate metabolism
spu00260  Glycine, serine and threonine metabolism
spu00340  Histidine metabolism
spu00630  Glyoxylate and dicarboxylate metabolism
spu00730  Thiamine metabolism
spu00740  Riboflavin metabolism
spu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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