KEGG   PATHWAY: stru04914
Entry
stru04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Salmo trutta (river trout)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
stru04914  Progesterone-mediated oocyte maturation
stru04914

Other DBs
GO: 0001556
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115163863  progesterone receptor-like [KO:K08556]
115192204  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115169527  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115158103  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115169950  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115158753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115159695  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
115156743  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
115167650  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
115157257  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115151679  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
115203963  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115170061  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115158422  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115165908  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
115163651  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
115156658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
115206538  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115152195  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115180302  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115180375  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
115169006  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115169019  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
115165421  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115165434  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115166089  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
115151057  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
115207356  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115197396  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115198903  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
115198904  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
115152154  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
115180555  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
115168690  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115165324  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115150537  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
115150599  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115150976  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
115207454  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
115207803  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
115207876  guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630]
115197349  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
115199006  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
115169640  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115158652  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
115157130  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
115173833  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115175633  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
115191681  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
115175579  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115177411  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
115155606  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
115160940  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
115167808  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115168355  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115165462  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
115166185  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
115167552  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
115203287  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
115161910  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
115156513  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
115171775  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115178829  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115147400  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
115206444  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
115157937  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115181703  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115169621  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
115171557  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115178387  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
115157154  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115204162  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115207352  aurora kinase C-like [KO:K11481] [EC:2.7.11.1]
115193971  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
115168109  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115192404  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
115153041  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
115153968  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115158500  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
115166823  cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602]
115148503  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115203503  cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602]
115197157  cytoplasmic polyadenylation element-binding protein 1-like isoform X1 [KO:K02602]
115205641  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
115202797  spdya; speedy protein A isoform X1 [KO:K08694]
115150457  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115207965  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
115193676  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115153283  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115170290  cyclin-A2-like [KO:K06627]
115204637  ccna1; cyclin-A1 [KO:K06627]
115205091  cyclin-A2-like [KO:K06627]
115195699  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
115174522  heat shock protein HSP 90-alpha [KO:K04079]
115174523  heat shock protein HSP 90-alpha 1-like [KO:K04079]
115168508  heat shock protein HSP 90-alpha-like [KO:K04079]
115168577  heat shock protein HSP 90-alpha 1 [KO:K04079]
115174992  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
115196028  heat shock protein HSP 90-beta-like [KO:K04079]
115192967  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115153452  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115154782  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115162588  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
115166122  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
115172888  ribosomal protein S6 kinase 2 alpha-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115151715  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
115201621  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
115204387  ribosomal protein S6 kinase alpha-3-like isoform X1 [KO:K04373] [EC:2.7.11.1]
115162173  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
115159595  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115203015  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
115204043  G2/mitotic-specific cyclin-B1-like [KO:K05868]
115163682  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
115167247  G2/mitotic-specific cyclin-B2-like [KO:K21770]
115190418  G2/mitotic-specific cyclin-B3-like [KO:K21771]
115153996  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
115148539  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
115185196  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
115161818  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
115173049  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
115204425  M-phase inducer phosphatase 1-B-like isoform X1 [KO:K05867] [EC:3.1.3.48]
115190165  insulin-like [KO:K04526]
115153684  insulin-like [KO:K04526]
115148215  insulin [KO:K04526]
115180501  insulin-like growth factor I isoform X1 [KO:K05459]
115198940  insulin-like growth factor I isoform X1 [KO:K05459]
115182685  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115151978  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115196778  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115203659  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
115191758  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115174699  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115162386  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115154910  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115163684  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115178760  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115172667  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115206563  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115201509  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115208587  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
115204542  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115167086  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
115203236  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
115152163  GTPase KRas isoform X1 [KO:K07827]
115171866  GTPase HRas-like [KO:K07827]
115207704  GTPase HRas-like [KO:K07827]
115197360  GTPase KRas isoform X1 [KO:K07827]
115164256  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
115200393  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K08845] [EC:2.7.11.1]
115183182  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
115183708  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
115168396  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115166136  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
115149903  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115174940  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115194477  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
115178485  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
115147910  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
115194121  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115198132  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
115168171  mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
115169408  fizzy-related protein homolog [KO:K03364]
115158407  fizzy-related protein homolog isoform X1 [KO:K03364]
115157255  fizzy-related protein homolog [KO:K03364]
115157414  fizzy-related protein homolog [KO:K03364]
115153320  anaphase-promoting complex subunit 1-like isoform X1 [KO:K03348]
115159591  anaphase-promoting complex subunit 2-like [KO:K03349]
115204046  anaphase-promoting complex subunit 2-like [KO:K03349]
115170940  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115196412  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
115158508  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
115200012  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
115160605  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115156222  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
115164667  anaphase-promoting complex subunit 7-like [KO:K03354]
115199969  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
115154817  cell division cycle protein 23 homolog [KO:K03355]
115204429  cell division cycle protein 23 homolog [KO:K03355]
115194734  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
115177593  anaphase-promoting complex subunit 11 [KO:K03358]
115208656  anaphase-promoting complex subunit 11-like [KO:K03358]
115159715  anaphase-promoting complex subunit CDC26-like isoform X1 [KO:K03359]
115203956  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
115148692  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
115163715  anaphase-promoting complex subunit 15-like isoform X1 [KO:K25228]
115206593  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
115152741  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
115162397  kif22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
stru04010  MAPK signaling pathway
stru04110  Cell cycle
KO pathway
ko04914   
LinkDB

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