KEGG   PATHWAY: tad04148
Entry
tad04148                    Pathway                                
Name
Efferocytosis - Trichoplax adhaerens (placozoan)
Class
Cellular Processes; Transport and catabolism
Pathway map
tad04148  Efferocytosis
tad04148

Organism
Trichoplax adhaerens (placozoan) [GN:tad]
Gene
TRIADDRAFT_16140  hypothetical protein [KO:K02187] [EC:3.4.22.56]
TRIADDRAFT_50539  hypothetical protein [KO:K04397] [EC:3.4.22.60]
TRIADDRAFT_51430  hypothetical protein [KO:K04718] [EC:2.7.1.91]
TRIADDRAFT_20947  hypothetical protein [KO:K04718] [EC:2.7.1.91]
TRIADDRAFT_10137  hypothetical protein [KO:K05641]
TRIADDRAFT_58971  hypothetical protein [KO:K06059] [EC:3.4.24.86]
TRIADDRAFT_19172  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_56535  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_51549  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_60597  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_62135  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_19354  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_51548  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_52298  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_62134  hypothetical protein [KO:K06704] [EC:3.4.24.81]
TRIADDRAFT_14211  hypothetical protein [KO:K09097]
TRIADDRAFT_61274  hypothetical protein [KO:K04447] [EC:2.7.10.2]
TRIADDRAFT_50661  hypothetical protein [KO:K04371] [EC:2.7.11.24]
TRIADDRAFT_49897  hypothetical protein [KO:K08524]
TRIADDRAFT_58786  hypothetical protein [KO:K04261]
TRIADDRAFT_54968  hypothetical protein [KO:K05870]
TRIADDRAFT_28963  hypothetical protein [KO:K05853] [EC:7.2.2.10]
TRIADDRAFT_50756  hypothetical protein [KO:K04515] [EC:2.7.11.17]
TRIADDRAFT_31065  hypothetical protein [KO:K04515] [EC:2.7.11.17]
TRIADDRAFT_50163  hypothetical protein [KO:K04441] [EC:2.7.11.24]
TRIADDRAFT_56817  hypothetical protein [KO:K04443] [EC:2.7.11.1]
TRIADDRAFT_50085  hypothetical protein [KO:K00461] [EC:1.13.11.34]
TRIADDRAFT_63720  hypothetical protein [KO:K00461] [EC:1.13.11.34]
TRIADDRAFT_54261  hypothetical protein [KO:K19499]
TRIADDRAFT_10718  hypothetical protein [KO:K19501]
TRIADDRAFT_57933  hypothetical protein [KO:K26811]
TRIADDRAFT_25047  hypothetical protein [KO:K14802] [EC:7.6.2.1]
TRIADDRAFT_56098  hypothetical protein [KO:K26934] [EC:7.6.2.1]
TRIADDRAFT_19365  hypothetical protein [KO:K26935]
TRIADDRAFT_27547  hypothetical protein [KO:K05725] [EC:2.7.10.2]
TRIADDRAFT_55703  hypothetical protein [KO:K12366]
TRIADDRAFT_58664  hypothetical protein [KO:K13708]
TRIADDRAFT_49573  Rac1 protein [KO:K04392]
TRIADDRAFT_49916  hypothetical protein [KO:K04392]
TRIADDRAFT_19073  hypothetical protein [KO:K04392]
TRIADDRAFT_20140  hypothetical protein [KO:K04392]
TRIADDRAFT_19095  hypothetical protein [KO:K04392]
TRIADDRAFT_63359  hypothetical protein [KO:K08057]
TRIADDRAFT_52079  hypothetical protein [KO:K20177]
TRIADDRAFT_54511  hypothetical protein [KO:K20178]
TRIADDRAFT_28801  hypothetical protein [KO:K20179]
TRIADDRAFT_20725  hypothetical protein [KO:K20180]
TRIADDRAFT_55631  hypothetical protein [KO:K20181]
TRIADDRAFT_57259  hypothetical protein [KO:K20182]
TRIADDRAFT_49865  hypothetical protein [KO:K07881]
TRIADDRAFT_61902  hypothetical protein [KO:K20183]
TRIADDRAFT_54975  hypothetical protein [KO:K20184]
TRIADDRAFT_20105  Rab7 protein [KO:K07897]
TRIADDRAFT_52723  hypothetical protein [KO:K01476] [EC:3.5.3.1]
TRIADDRAFT_27475  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_19621  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_53993  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_52094  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_62377  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_31473  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_60902  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_31500  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_60904  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_60920  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_60921  hypothetical protein [KO:K01581] [EC:4.1.1.17]
TRIADDRAFT_55550  hypothetical protein [KO:K08765] [EC:2.3.1.21]
TRIADDRAFT_23733  hypothetical protein [KO:K08765] [EC:2.3.1.21]
TRIADDRAFT_24746  hypothetical protein [KO:K00411] [EC:7.1.1.8]
TRIADDRAFT_21171  hypothetical protein [KO:K09355]
TRIADDRAFT_54597  hypothetical protein [KO:K01052] [EC:3.1.1.13]
TRIADDRAFT_59600  hypothetical protein [KO:K06129] [EC:3.1.1.5]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
tad00010  Glycolysis / Gluconeogenesis
tad04140  Autophagy - animal
tad04145  Phagosome
KO pathway
ko04148   
LinkDB

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