KEGG   PATHWAY: taes03440
Entry
taes03440                   Pathway                                
Name
Homologous recombination - Triticum aestivum (bread wheat)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
taes03440  Homologous recombination
taes03440

Other DBs
GO: 0000724
Organism
Triticum aestivum (bread wheat) [GN:taes]
Gene
123078651  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
123061580  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
123070212  single-stranded DNA-binding protein, mitochondrial-like [KO:K03111]
123113227  DNA repair protein recA homolog 1, chloroplastic-like [KO:K03553]
123080022  DNA repair protein recA homolog 3, mitochondrial-like [KO:K03553]
123062829  DNA repair protein recA homolog 3, mitochondrial-like [KO:K03553]
123122736  DNA repair protein recA homolog 1, chloroplastic-like [KO:K03553]
123104926  DNA repair protein recA homolog 1, chloroplastic-like isoform X1 [KO:K03553]
123071677  DNA repair protein recA homolog 3, mitochondrial-like [KO:K03553]
123156588  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
123190853  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
123147085  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
123055005  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
123047203  DNA polymerase I A, chloroplastic-like [KO:K02335] [EC:2.7.7.7]
123128158  ATP-dependent DNA helicase homolog RECG, chloroplastic-like isoform X1 [KO:K03655] [EC:5.6.2.4]
123137961  ATP-dependent DNA helicase homolog RECG, chloroplastic-like [KO:K03655] [EC:5.6.2.4]
123145259  ATP-dependent DNA helicase homolog RECG, chloroplastic-like [KO:K03655] [EC:5.6.2.4]
123110672  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
123119676  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
123102504  DNA repair protein RAD50-like [KO:K10866] [EC:3.6.-.-]
123167566  double-strand break repair protein MRE11-like [KO:K10865]
123047225  double-strand break repair protein MRE11-like isoform X1 [KO:K10865]
123190879  double-strand break repair protein MRE11-like isoform X1 [KO:K10865]
123151898  double-strand break repair protein MRE11-like [KO:K10865]
123161400  double-strand break repair protein MRE11-like [KO:K10865]
123055023  double-strand break repair protein MRE11 isoform X1 [KO:K10865]
123046539  nijmegen breakage syndrome 1 protein-like [KO:K10867]
123122050  nijmegen breakage syndrome 1 protein-like [KO:K10867]
123181133  nijmegen breakage syndrome 1 protein-like [KO:K10867]
123062353  serine/threonine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
123139615  serine/threonine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
123182586  serine/threonine-protein kinase ATM-like isoform X1 [KO:K04728] [EC:2.7.11.1]
123060331  uncharacterized protein LOC123060331 isoform X1 [KO:K10683]
123094424  BRCA1-associated RING domain protein 1-like [KO:K10683]
123046135  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
123062367  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
123189904  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
123040853  BRCA1-associated RING domain protein 1-like isoform X1 [KO:K10683]
123048868  BRCA1-associated RING domain protein 1-like isoform X1 [KO:K10683]
123139632  protein BREAST CANCER SUSCEPTIBILITY 1 homolog [KO:K10683]
123054018  BRCA1-associated RING domain protein 1-like [KO:K10683]
123182393  BRCA1-associated RING domain protein 1-like [KO:K10683]
123092179  uncharacterized protein LOC123092179 isoform X1 [KO:K10683]
123184872  protein BREAST CANCER SUSCEPTIBILITY 1 homolog isoform X1 [KO:K10683]
123113021  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
123104739  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
123122537  Fanconi anemia group J protein homolog isoform X1 [KO:K15362] [EC:5.6.2.3]
123043588  BRCT domain-containing protein At4g02110-like [KO:K10728]
123187396  BRCT domain-containing protein At4g02110-like isoform X1 [KO:K10728]
123046156  BRCT domain-containing protein At4g02110-like [KO:K10728]
123096291  DNA topoisomerase 2-binding protein 1-A-like isoform X1 [KO:K10728]
123132068  BRCT domain-containing protein At4g02110-like [KO:K10728]
123189929  BRCT domain-containing protein At4g02110-like [KO:K10728]
123136092  BRCT domain-containing protein At4g02110-like [KO:K10728]
123051457  uncharacterized protein LOC123051457 [KO:K10728]
123086706  DNA topoisomerase 2-binding protein 1-A-like [KO:K10728]
123053702  uncharacterized protein LOC123053702 [KO:K10728]
123091315  DNA topoisomerase 2-binding protein 1-A-like isoform X1 [KO:K10728]
123143604  BRCT domain-containing protein At4g02110-like [KO:K10728]
123167200  uncharacterized protein LOC123167200 [KO:K20776]
123151001  uncharacterized protein LOC123151001 [KO:K20776]
123088079  uncharacterized protein LOC123088079 [KO:K20776]
123165304  BRISC and BRCA1-A complex member 2-like [KO:K12173]
123148295  BRISC and BRCA1-A complex member 2-like [KO:K12173]
123157368  BRISC and BRCA1-A complex member 2-like isoform X1 [KO:K12173]
123065475  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
123143018  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
123182841  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
123060317  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like isoform X1 [KO:K08775]
123077330  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like isoform X1 [KO:K08775]
123068835  protein BREAST CANCER SUSCEPTIBILITY 2 homolog B-like isoform X1 [KO:K08775]
123078156  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
123061084  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
123069673  protein DELETION OF SUV3 SUPPRESSOR 1(I)-like [KO:K10881]
123128602  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
123138475  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
123172141  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
123180384  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
123186983  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
123190781  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
123111083  replication protein A 70 kDa DNA-binding subunit C-like [KO:K07466]
123145722  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
123098249  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
123085080  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
123092976  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
123129156  replication protein A 32 kDa subunit A-like [KO:K10739]
123146332  replication protein A 32 kDa subunit A-like [KO:K10739]
123147332  replication protein A 32 kDa subunit B-like isoform X1 [KO:K10739]
123097005  replication protein A 32 kDa subunit B-like [KO:K10739]
123149194  uncharacterized protein LOC123149194 isoform X1 [KO:K10739]
123133337  uncharacterized protein LOC123133337 isoform X1 [KO:K10739]
123191627  replication protein A 32 kDa subunit B-like [KO:K10739]
123136291  uncharacterized protein LOC123136291 [KO:K10739]
123154325  replication protein A 32 kDa subunit B-like [KO:K10739]
123137578  replication protein A 32 kDa subunit B-like [KO:K10739]
123086684  replication protein A 32 kDa subunit B-like [KO:K10739]
123086766  replication protein A 32 kDa subunit B-like [KO:K10739]
123140070  replication protein A 32 kDa subunit A-like [KO:K10739]
123181452  replication protein A 32 kDa subunit B-like isoform X1 [KO:K10739]
123127691  replication protein A 32 kDa subunit B-like [KO:K10739]
123144900  replication protein A 32 kDa subunit B-like [KO:K10739]
123078038  replication protein A 14 kDa subunit-like [KO:K10740]
123078093  replication protein A 14 kDa subunit-like [KO:K10740]
123060954  replication protein A 14 kDa subunit-like [KO:K10740]
123061021  replication protein A 14 kDa subunit-like [KO:K10740]
123069552  replication protein A 14 kDa subunit-like isoform X1 [KO:K10740]
123069607  replication protein A 14 kDa subunit-like [KO:K10740]
100240700  DNA repair protein RAD51 homolog B [KO:K04482]
100192175  DNA repair protein RAD51 homolog B [KO:K04482]
123161438  DNA repair protein RAD51 homolog B-like [KO:K04482]
123188669  DNA repair protein RAD51 homolog 2-like [KO:K10869]
123103406  DNA repair protein RAD51 homolog 2-like [KO:K10869]
123107424  DNA repair protein RAD51 homolog 2-like isoform X1 [KO:K10869]
123164527  DNA repair protein RAD51 homolog 2-like [KO:K10869]
100192184  DNA repair protein RAD51 homolog 3 isoform X1 [KO:K10870]
123188297  DNA repair protein RAD51 homolog 3-like [KO:K10870]
123052428  DNA repair protein RAD51 homolog 3-like [KO:K10870]
100192176  DNA repair protein RAD51 homolog 4 [KO:K10871]
123154353  DNA repair protein RAD51 homolog 4-like [KO:K10871]
123162090  DNA repair protein RAD51 homolog 4-like isoform X1 [KO:K10871]
123079905  DNA repair protein XRCC2 homolog [KO:K10879]
123071568  DNA repair protein XRCC2 homolog isoform X1 [KO:K10879]
123057050  DNA repair protein XRCC2 homolog [KO:K10879]
123134150  DNA repair protein XRCC3 homolog [KO:K10880]
123141454  DNA repair protein XRCC3 homolog [KO:K10880]
123127489  DNA repair protein XRCC3 homolog [KO:K10880]
123043556  SNF2 domain-containing protein CLASSY 2-like [KO:K10875] [EC:5.6.2.-]
123043957  protein CHROMATIN REMODELING 35-like isoform X1 [KO:K10875] [EC:5.6.2.-]
123093260  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123128487  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
123145612  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
123044333  protein CHROMATIN REMODELING 35-like isoform X1 [KO:K10875] [EC:5.6.2.-]
123187729  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123078563  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
123061480  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
123061640  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
123131456  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
123098528  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123134343  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
123048400  uncharacterized protein LOC123048400 [KO:K10875] [EC:5.6.2.-]
123083698  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123051414  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
123051831  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123138366  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
123052197  protein CHROMATIN REMODELING 35-like [KO:K10875] [EC:5.6.2.-]
123070118  SNF2 domain-containing protein CLASSY 3-like [KO:K10875] [EC:5.6.2.-]
123104662  uncharacterized protein LOC123104662 [KO:K10875] [EC:5.6.2.-]
123181895  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
123054507  SNF2 domain-containing protein CLASSY 1-like [KO:K10875] [EC:5.6.2.-]
123184633  SNF2 domain-containing protein CLASSY 2-like [KO:K10875] [EC:5.6.2.-]
123096285  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
123086692  DNA polymerase delta catalytic subunit-like isoform X1 [KO:K02327] [EC:2.7.7.7]
123091308  DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
123093569  DNA polymerase delta small subunit-like [KO:K02328]
123098837  DNA polymerase delta small subunit [KO:K02328]
123105753  DNA polymerase delta small subunit [KO:K02328]
123077688  protein IWS1 homolog A-like [KO:K03504]
123060609  protein IWS1 homolog A-like [KO:K03504]
123069162  protein IWS1 homolog A-like isoform X1 [KO:K03504]
123112740  DNA polymerase delta subunit 4-like [KO:K03505]
123063507  uncharacterized protein LOC123063507 [KO:K03505]
123050158  uncharacterized protein LOC123050158 isoform X1 [KO:K03505]
123104445  uncharacterized protein LOC123104445 [KO:K03505]
123140641  uncharacterized protein LOC123140641 [KO:K03505]
123124400  DNA polymerase delta subunit 4-like [KO:K03505]
123124715  DNA polymerase delta subunit 4-like [KO:K03505]
123125017  DNA polymerase delta subunit 4-like [KO:K03505]
123125191  uncharacterized protein LOC123125191 [KO:K03505]
123182664  uncharacterized protein LOC123182664 [KO:K03505]
123126289  DNA polymerase delta subunit 4-like [KO:K03505]
123128632  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:5.6.2.4]
123145766  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:5.6.2.4]
123045493  ATP-dependent DNA helicase Q-like 4A isoform X1 [KO:K10901] [EC:5.6.2.4]
123189243  ATP-dependent DNA helicase Q-like 4A isoform X1 [KO:K10901] [EC:5.6.2.4]
123138522  ATP-dependent DNA helicase Q-like 3 [KO:K10901] [EC:5.6.2.4]
123053342  ATP-dependent DNA helicase Q-like 4A [KO:K10901] [EC:5.6.2.4]
123093258  DNA topoisomerase 3-alpha-like [KO:K03165] [EC:5.6.2.1]
123112523  DNA topoisomerase 3-beta [KO:K03165] [EC:5.6.2.1]
123098524  DNA topoisomerase 3-alpha-like [KO:K03165] [EC:5.6.2.1]
123084825  DNA topoisomerase 3-alpha-like [KO:K03165] [EC:5.6.2.1]
123122023  DNA topoisomerase 3-beta-like isoform X1 [KO:K03165] [EC:5.6.2.1]
123104259  DNA topoisomerase 3-beta-like isoform X1 [KO:K03165] [EC:5.6.2.1]
123078178  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123061103  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
123113047  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123080681  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123063448  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123063450  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123069693  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123157888  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
123072455  crossover junction endonuclease MUS81-like isoform X1 [KO:K08991] [EC:3.1.22.-]
123057033  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
123047125  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
123047126  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
123190788  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
123190789  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
123054935  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
123054936  crossover junction endonuclease EME1-like [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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